2-amino-5-phosphonovalerate and Benign Psychomotor Epilepsy, Childhood
2-amino-5-phosphonovalerate has been researched along with Benign Psychomotor Epilepsy, Childhood in 21 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 5.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
" Application of APV and nifedipine exacerbated low Mg(2+)-induced ILEs in the hippocampus but not the neocortex, indicating a distinct pharmacology for partial seizures of different brain regions." | 3.73 | Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro. ( Abdelmalik, PA; Burnham, WM; Carlen, PL, 2005) |
"Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 1.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
"Seizures were blocked by glutamate receptor antagonists, suggesting that plasticity in excitatory synaptic circuits contributed to seizures." | 1.33 | Plasticity of both excitatory and inhibitory synapses is associated with seizures induced by removal of chronic blockade of activity in cultured hippocampus. ( Bausch, SB; He, S; McNamara, JO; Petrova, Y; Wang, XM, 2006) |
"Neuropeptide Y (NPY) has been shown to depress hyperexcitable activity that has been acutely induced in the normal rat brain." | 1.30 | NPY inhibits glutamatergic excitation in the epileptic human dentate gyrus. ( Patrylo, PR; Spencer, DD; van den Pol, AN; Williamson, A, 1999) |
Research
Studies (21)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (4.76) | 18.7374 |
1990's | 11 (52.38) | 18.2507 |
2000's | 4 (19.05) | 29.6817 |
2010's | 5 (23.81) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Ivanov, AD | 1 |
Zaitsev, AV | 1 |
Clasadonte, J | 1 |
Dong, J | 1 |
Hines, DJ | 1 |
Haydon, PG | 1 |
Langlois, M | 1 |
Polack, PO | 1 |
Bernard, H | 1 |
David, O | 1 |
Charpier, S | 1 |
Depaulis, A | 1 |
Deransart, C | 1 |
Häussler, U | 1 |
Bielefeld, L | 1 |
Froriep, UP | 1 |
Wolfart, J | 1 |
Haas, CA | 1 |
Abdelmalik, PA | 1 |
Burnham, WM | 1 |
Carlen, PL | 1 |
Bausch, SB | 1 |
He, S | 1 |
Petrova, Y | 1 |
Wang, XM | 1 |
McNamara, JO | 1 |
Bernard, CL | 1 |
Wheal, HV | 1 |
Williamson, A | 3 |
Spencer, D | 1 |
Uruno, K | 2 |
O'Connor, MJ | 3 |
Masukawa, LM | 3 |
Buhl, EH | 1 |
Otis, TS | 1 |
Mody, I | 2 |
Wang, H | 1 |
Mangan, PS | 1 |
Bertram, EH | 1 |
Wu, C | 1 |
Leung, LS | 1 |
Patrylo, PR | 3 |
Dudek, FE | 1 |
Spencer, DD | 3 |
van den Pol, AN | 1 |
Kivi, A | 1 |
Lehmann, TN | 1 |
Kovács, R | 1 |
Eilers, A | 1 |
Jauch, R | 1 |
Meencke, HJ | 1 |
von Deimling, A | 1 |
Heinemann, U | 2 |
Gabriel, S | 1 |
Behr, J | 1 |
Higashima, M | 1 |
Hart, GJ | 1 |
Avoli, M | 1 |
Olivier, A | 1 |
Huberfeld, G | 1 |
Menendez de la Prida, L | 1 |
Pallud, J | 1 |
Cohen, I | 1 |
Le Van Quyen, M | 1 |
Adam, C | 1 |
Clemenceau, S | 1 |
Baulac, M | 1 |
Miles, R | 1 |
Other Studies
21 other studies available for 2-amino-5-phosphonovalerate and Benign Psychomotor Epilepsy, Childhood
Article | Year |
---|---|
NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Mode | 2017 |
Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Electroencephalography; Epilepsy, Temporal Lobe; E | 2013 |
Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Biophysical Phenomena; Disease Models, Anim | 2010 |
Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Br | 2012 |
Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channel Blockers | 2005 |
Plasticity of both excitatory and inhibitory synapses is associated with seizures induced by removal of chronic blockade of activity in cultured hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anesthetics, Local; Animals; Epilepsy, Temporal Lobe | 2006 |
Simultaneous expression of long-term depression of NMDA and long-term potentiation of AMPA receptor-mediated synaptic responses in the CA1 area of the kainic acid-lesioned hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Elect | 1995 |
Zinc reduces dentate granule cell hyperexcitability in epileptic humans.
Topics: 2-Amino-5-phosphonovalerate; Dentate Gyrus; Epilepsy, Temporal Lobe; Evoked Potentials; Humans; In V | 1995 |
Alterations of inhibitory synaptic responses in the dentate gyrus of temporal lobe epileptic patients.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adult; Bicucul | 1994 |
Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Chlorides; Dentate Gyrus | 1996 |
Prolonged field potentials evoked by 1 Hz stimulation in the dentate gyrus of temporal lobe epileptic human brain slices.
Topics: 2-Amino-5-phosphonovalerate; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysiology; Ep | 1996 |
Shortened-duration GABA(A) receptor-mediated synaptic potentials underlie enhanced CA1 excitability in a chronic model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Disea | 1997 |
Partial hippocampal kindling decreases efficacy of presynaptic GABAB autoreceptors in CA1.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Epile | 1997 |
Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysi | 1998 |
Decrease in inhibition in dentate granule cells from patients with medial temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Dentate Gyrus; Electric Conductiv | 1999 |
NPY inhibits glutamatergic excitation in the epileptic human dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Animals; Axons; Dentate Gyrus; Electric Stimulation; El | 1999 |
Effects of barium on stimulus-induced rises of [K+]o in human epileptic non-sclerotic and sclerotic hippocampal area CA1.
Topics: 2-Amino-5-phosphonovalerate; Adult; Barium Compounds; Bicuculline; Buffers; Chlorides; Electric Stim | 2000 |
Glutamate receptor activation in the kindled dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dentate Gyrus; Entorhinal Cortex; Epilepsy, Temporal Lobe; Exc | 2000 |
NMDA receptor activation during epileptiform responses in the dentate gyrus of epileptic patients.
Topics: 2-Amino-5-phosphonovalerate; Electric Stimulation; Epilepsy, Temporal Lobe; Evoked Potentials; Hippo | 1991 |
Bursting in human epileptogenic neocortex is depressed by an N-methyl-D-aspartate antagonist.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anticonvulsants; Aspartic Acid; Epilepsy, Temporal L | 1987 |
Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy.
Topics: Action Potentials; Adolescent; Adult; Analysis of Variance; Biophysics; Brain Mapping; Confidence In | 2011 |