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2-amino-5-phosphonovalerate and Benign Psychomotor Epilepsy, Childhood

2-amino-5-phosphonovalerate has been researched along with Benign Psychomotor Epilepsy, Childhood in 21 studies

2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Research Excerpts

ExcerptRelevanceReference
"Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits."5.46NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017)
" Application of APV and nifedipine exacerbated low Mg(2+)-induced ILEs in the hippocampus but not the neocortex, indicating a distinct pharmacology for partial seizures of different brain regions."3.73Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro. ( Abdelmalik, PA; Burnham, WM; Carlen, PL, 2005)
"Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits."1.46NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017)
"Seizures were blocked by glutamate receptor antagonists, suggesting that plasticity in excitatory synaptic circuits contributed to seizures."1.33Plasticity of both excitatory and inhibitory synapses is associated with seizures induced by removal of chronic blockade of activity in cultured hippocampus. ( Bausch, SB; He, S; McNamara, JO; Petrova, Y; Wang, XM, 2006)
"Neuropeptide Y (NPY) has been shown to depress hyperexcitable activity that has been acutely induced in the normal rat brain."1.30NPY inhibits glutamatergic excitation in the epileptic human dentate gyrus. ( Patrylo, PR; Spencer, DD; van den Pol, AN; Williamson, A, 1999)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.76)18.7374
1990's11 (52.38)18.2507
2000's4 (19.05)29.6817
2010's5 (23.81)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ivanov, AD1
Zaitsev, AV1
Clasadonte, J1
Dong, J1
Hines, DJ1
Haydon, PG1
Langlois, M1
Polack, PO1
Bernard, H1
David, O1
Charpier, S1
Depaulis, A1
Deransart, C1
Häussler, U1
Bielefeld, L1
Froriep, UP1
Wolfart, J1
Haas, CA1
Abdelmalik, PA1
Burnham, WM1
Carlen, PL1
Bausch, SB1
He, S1
Petrova, Y1
Wang, XM1
McNamara, JO1
Bernard, CL1
Wheal, HV1
Williamson, A3
Spencer, D1
Uruno, K2
O'Connor, MJ3
Masukawa, LM3
Buhl, EH1
Otis, TS1
Mody, I2
Wang, H1
Mangan, PS1
Bertram, EH1
Wu, C1
Leung, LS1
Patrylo, PR3
Dudek, FE1
Spencer, DD3
van den Pol, AN1
Kivi, A1
Lehmann, TN1
Kovács, R1
Eilers, A1
Jauch, R1
Meencke, HJ1
von Deimling, A1
Heinemann, U2
Gabriel, S1
Behr, J1
Higashima, M1
Hart, GJ1
Avoli, M1
Olivier, A1
Huberfeld, G1
Menendez de la Prida, L1
Pallud, J1
Cohen, I1
Le Van Quyen, M1
Adam, C1
Clemenceau, S1
Baulac, M1
Miles, R1

Other Studies

21 other studies available for 2-amino-5-phosphonovalerate and Benign Psychomotor Epilepsy, Childhood

ArticleYear
NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy.
    Synapse (New York, N.Y.), 2017, Volume: 71, Issue:8

    Topics: 2-Amino-5-phosphonovalerate; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Mode

2017
Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Oct-22, Volume: 110, Issue:43

    Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Electroencephalography; Epilepsy, Temporal Lobe; E

2013
Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Dec-08, Volume: 30, Issue:49

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Biophysical Phenomena; Disease Models, Anim

2010
Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy.
    Cerebral cortex (New York, N.Y. : 1991), 2012, Volume: 22, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Br

2012
Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro.
    Epilepsia, 2005, Volume: 46, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channel Blockers

2005
Plasticity of both excitatory and inhibitory synapses is associated with seizures induced by removal of chronic blockade of activity in cultured hippocampus.
    Journal of neurophysiology, 2006, Volume: 96, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anesthetics, Local; Animals; Epilepsy, Temporal Lobe

2006
Simultaneous expression of long-term depression of NMDA and long-term potentiation of AMPA receptor-mediated synaptic responses in the CA1 area of the kainic acid-lesioned hippocampus.
    The European journal of neuroscience, 1995, Jul-01, Volume: 7, Issue:7

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Elect

1995
Zinc reduces dentate granule cell hyperexcitability in epileptic humans.
    Neuroreport, 1995, Jul-31, Volume: 6, Issue:11

    Topics: 2-Amino-5-phosphonovalerate; Dentate Gyrus; Epilepsy, Temporal Lobe; Evoked Potentials; Humans; In V

1995
Alterations of inhibitory synaptic responses in the dentate gyrus of temporal lobe epileptic patients.
    Hippocampus, 1994, Volume: 4, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adult; Bicucul

1994
Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model.
    Science (New York, N.Y.), 1996, Jan-19, Volume: 271, Issue:5247

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Chlorides; Dentate Gyrus

1996
Prolonged field potentials evoked by 1 Hz stimulation in the dentate gyrus of temporal lobe epileptic human brain slices.
    Brain research, 1996, May-20, Volume: 721, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysiology; Ep

1996
Shortened-duration GABA(A) receptor-mediated synaptic potentials underlie enhanced CA1 excitability in a chronic model of temporal lobe epilepsy.
    Neuroscience, 1997, Volume: 80, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Disea

1997
Partial hippocampal kindling decreases efficacy of presynaptic GABAB autoreceptors in CA1.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Dec-01, Volume: 17, Issue:23

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Epile

1997
Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats.
    Journal of neurophysiology, 1998, Volume: 79, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysi

1998
Decrease in inhibition in dentate granule cells from patients with medial temporal lobe epilepsy.
    Annals of neurology, 1999, Volume: 45, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Dentate Gyrus; Electric Conductiv

1999
NPY inhibits glutamatergic excitation in the epileptic human dentate gyrus.
    Journal of neurophysiology, 1999, Volume: 82, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Animals; Axons; Dentate Gyrus; Electric Stimulation; El

1999
Effects of barium on stimulus-induced rises of [K+]o in human epileptic non-sclerotic and sclerotic hippocampal area CA1.
    The European journal of neuroscience, 2000, Volume: 12, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; Adult; Barium Compounds; Bicuculline; Buffers; Chlorides; Electric Stim

2000
Glutamate receptor activation in the kindled dentate gyrus.
    Epilepsia, 2000, Volume: 41 Suppl 6

    Topics: 2-Amino-5-phosphonovalerate; Animals; Dentate Gyrus; Entorhinal Cortex; Epilepsy, Temporal Lobe; Exc

2000
NMDA receptor activation during epileptiform responses in the dentate gyrus of epileptic patients.
    Brain research, 1991, Oct-18, Volume: 562, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Electric Stimulation; Epilepsy, Temporal Lobe; Evoked Potentials; Hippo

1991
Bursting in human epileptogenic neocortex is depressed by an N-methyl-D-aspartate antagonist.
    Neuroscience letters, 1987, May-06, Volume: 76, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anticonvulsants; Aspartic Acid; Epilepsy, Temporal L

1987
Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy.
    Nature neuroscience, 2011, Volume: 14, Issue:5

    Topics: Action Potentials; Adolescent; Adult; Analysis of Variance; Biophysics; Brain Mapping; Confidence In

2011
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