2-amino-5-phosphonovalerate has been researched along with Aura in 134 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival." | 7.70 | Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2000) |
| "Two selective excitatory amino acid antagonists, DL-(E)-2-amino-4-methyl- 5-phosphono-3-pentenoic acid (CGP 37849) and its carboxyethylester (CGP 39551), were studied against audiogenic seizures in genetically epilepsy-prone rats following oral administration." | 7.69 | Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats. ( Ammendola, D; De Sarro, A; De Sarro, G; Patel, S, 1996) |
| " Bicuculline-induced epileptiform bursts in slices of neocortical tissue resected from children (3 mo to 14 yr) undergoing neurosurgical treatment for intractable epilepsy were studied with conventional intracellular recording techniques." | 7.68 | Properties and synaptic mechanisms of bicuculline-induced epileptiform bursts in neocortical slices from children with intractable epilepsy. ( Dudek, FE; Kim, YI; Peacock, WJ, 1993) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 7.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "Systemic administration of kainic acid results in the development of a characteristic convulsive syndrome, accompanied by neuropathological alterations and loss of transmitter markers in some forebrain regions." | 7.68 | Protection from kainic acid neuropathological syndrome by NMDA receptor antagonists: effect of MK-801 and CGP 39551 on neurotransmitter and glial markers. ( Barnabei, O; Contestabile, A; Migani, P; Virgili, M, 1992) |
| " Motor limbic seizures induced by pilocarpine, 380 mg/kg intraperitoneally, are prevented by prior injection into the substantia nigra, pars reticulata, or the entopeduncular nucleus, of 2-APH, 10 nmol or 10 pmol, respectively." | 4.77 | Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists. ( de Sarro, G; Meldrum, B; Millan, M; Patel, S, 1988) |
| "Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival." | 3.70 | Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2000) |
| "Two selective excitatory amino acid antagonists, DL-(E)-2-amino-4-methyl- 5-phosphono-3-pentenoic acid (CGP 37849) and its carboxyethylester (CGP 39551), were studied against audiogenic seizures in genetically epilepsy-prone rats following oral administration." | 3.69 | Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats. ( Ammendola, D; De Sarro, A; De Sarro, G; Patel, S, 1996) |
| " Bicuculline-induced epileptiform bursts in slices of neocortical tissue resected from children (3 mo to 14 yr) undergoing neurosurgical treatment for intractable epilepsy were studied with conventional intracellular recording techniques." | 3.68 | Properties and synaptic mechanisms of bicuculline-induced epileptiform bursts in neocortical slices from children with intractable epilepsy. ( Dudek, FE; Kim, YI; Peacock, WJ, 1993) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 3.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "Systemic administration of kainic acid results in the development of a characteristic convulsive syndrome, accompanied by neuropathological alterations and loss of transmitter markers in some forebrain regions." | 3.68 | Protection from kainic acid neuropathological syndrome by NMDA receptor antagonists: effect of MK-801 and CGP 39551 on neurotransmitter and glial markers. ( Barnabei, O; Contestabile, A; Migani, P; Virgili, M, 1992) |
| "The effects of ketamine and (+)cyclazocine on three in vitro models of epilepsy: the "Mg2+ free", the 4-aminopyridine (4-AP) and, for comparison, the penicillin model were studied." | 3.67 | Effects of ketamine and (+)cyclazocine on 4-aminopyridine and "magnesium free" epileptogenic activity in hippocampal slices of rats. ( de Carolis, AS; Frank, C; Sagratella, S, 1987) |
| " In contrast, in human neocortical preparations obtained from epilepsy surgery, in approximately 20% of the slices spontaneous epileptiform activity appeared with this bicuculline dosage without SDs." | 1.32 | Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue. ( Hagemann, G; Koch, UR; Köhling, R; Redecker, C; Speckmann, EJ; Straub, H, 2003) |
| "Limbic epilepsy is a chronic condition associated with a broad zone of seizure onset and pathology." | 1.31 | Aberrant neuronal physiology in the basal nucleus of the amygdala in a model of chronic limbic epilepsy. ( Bertram, EH; Mangan, PS; Scott, CA; Williamson, JM, 2000) |
| "Chlormethiazole has sedative, hypnotic, anticonvulsant and neuroprotective properties." | 1.31 | Chlormethiazole inhibits epileptiform activity by potentiating GABA(A) receptor function. ( Empson, RM; Gee, VJ; Newberry, NR; Sheardown, MJ, 2000) |
| " Evoked inhibitory postsynaptic currents (IPSCs) were decreased by kainate by up to 90%, showing a bell-shaped dose-response curve similar to that of native kainate-selective receptors." | 1.30 | Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus. ( Herreras, O; Lerma, J; Rodríguez-Moreno, A, 1997) |
| "Trimipramine has been classified as an atypical tricyclic antidepressant, because only weak inhibitory effects on serotonin and/or noradrenaline reuptake have been found." | 1.30 | Effects of the atypical antidepressant trimipramine on field potentials in the low Mg2+-model in guinea pig hippocampal slices. ( Berger, M; Langosch, JM; Repp, M; Walden, J, 1998) |
| "In this study, the anticonvulsant and adverse effects of compounds that belong to four different categories of systemically available N-methyl-D-aspartate (NMDA) receptor ligands were compared, namely the competitive antagonist CGP 40116, the noncompetitive antagonist MK-801 (dizocilpine), the glycineB receptor antagonist L-701,324, and the glycineB receptor high-efficacy partial agonist D-cycloserine." | 1.30 | Anti-convulsant and adverse effects of the glycineB receptor ligands, D-cycloserine and L-701,324: comparison with competitive and non-competitive N-methyl-D-aspartate receptor antagonists. ( Wlaź, P, 1998) |
| "Pregnancy is associated with a significant alteration of NMDA and non-NMDA receptor binding in rats." | 1.30 | N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats. ( Standley, CA, 1999) |
| "These seizure-like events (SLEs) comprised three distinct phases, called here primary, secondary, and tertiary bursts." | 1.30 | Seizure-like events in disinhibited ventral slices of adult rat hippocampus. ( Borck, C; Jefferys, JG, 1999) |
| "In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures." | 1.28 | NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. ( Anderson, WW; Clark, S; Stasheff, SF; Wilson, WA, 1989) |
| " A dose-response relation for NMDA activation indicated that bath application of 1 and 5 microM NMDA had little or no effect on the response to a paired stimulus pulse (triggered response) and did not induce spontaneous bursting." | 1.27 | The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice. ( Anderson, WW; Swartzwelder, HS; Wilson, WA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (14.93) | 18.7374 |
| 1990's | 64 (47.76) | 18.2507 |
| 2000's | 42 (31.34) | 29.6817 |
| 2010's | 8 (5.97) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Punnakkal, P | 1 |
| Dominic, D | 1 |
| Fuortes, MG | 1 |
| Faria, LC | 1 |
| Merlin, LR | 2 |
| Carriero, G | 1 |
| Uva, L | 1 |
| Gnatkovsky, V | 1 |
| Avoli, M | 5 |
| de Curtis, M | 1 |
| Kovács, Z | 1 |
| Czurkó, A | 1 |
| Kékesi, KA | 1 |
| Juhász, G | 1 |
| Kernig, K | 1 |
| Kirschstein, T | 1 |
| Würdemann, T | 1 |
| Rohde, M | 1 |
| Köhling, R | 3 |
| Cunningham, MO | 2 |
| Roopun, A | 1 |
| Schofield, IS | 1 |
| Whittaker, RG | 1 |
| Duncan, R | 1 |
| Russell, A | 1 |
| Jenkins, A | 1 |
| Nicholson, C | 1 |
| Whittington, MA | 2 |
| Traub, RD | 2 |
| Gulyás-Kovács, A | 1 |
| Dóczi, J | 1 |
| Tarnawa, I | 1 |
| Détári, L | 1 |
| Banczerowski-Pelyhe, I | 1 |
| Világi, I | 1 |
| Uusisaari, M | 1 |
| Smirnov, S | 1 |
| Voipio, J | 1 |
| Kaila, K | 1 |
| Koch, UR | 1 |
| Hagemann, G | 1 |
| Redecker, C | 1 |
| Straub, H | 2 |
| Speckmann, EJ | 3 |
| Zhang, DX | 1 |
| Bertram, EH | 2 |
| Roshan-Milani, S | 1 |
| Ferrigan, L | 1 |
| Khoshnood, MJ | 1 |
| Davies, CH | 3 |
| Cobb, SR | 2 |
| Verleye, M | 1 |
| André, N | 1 |
| Heulard, I | 1 |
| Gillardin, JM | 1 |
| Campbell, SL | 1 |
| Hablitz, JJ | 6 |
| Derchansky, M | 1 |
| Shahar, E | 1 |
| Wennberg, RA | 1 |
| Samoilova, M | 1 |
| Jahromi, SS | 1 |
| Abdelmalik, PA | 1 |
| Zhang, L | 1 |
| Carlen, PL | 1 |
| Feng, Z | 1 |
| Durand, DM | 1 |
| Slamberová, R | 1 |
| Mares, P | 2 |
| Raisinghani, M | 1 |
| Faingold, CL | 1 |
| Papatheodoropoulos, C | 1 |
| Moschovos, C | 1 |
| Kostopoulos, G | 1 |
| Kang, N | 1 |
| Xu, J | 1 |
| Xu, Q | 1 |
| Nedergaard, M | 1 |
| Kang, J | 1 |
| Lees, G | 1 |
| Stöhr, T | 1 |
| Errington, AC | 1 |
| Salamoni, SD | 1 |
| da Costa, JC | 1 |
| Palma, MS | 1 |
| Konno, K | 1 |
| Nihei, K | 1 |
| Azambuja, NA | 1 |
| Neto, EP | 1 |
| Venturin, GT | 1 |
| Tavares, AA | 1 |
| de Abreu, DS | 1 |
| Breda, RV | 1 |
| Gill, CH | 1 |
| Brown, JT | 2 |
| Shivji, N | 1 |
| Lappin, SC | 1 |
| Farmer, C | 1 |
| Randall, A | 2 |
| McNaughton, NC | 1 |
| Skov, J | 1 |
| Andreasen, M | 1 |
| Nedergaard, S | 1 |
| Schiller, Y | 1 |
| Bankirer, Y | 1 |
| Glasscock, E | 1 |
| Qian, J | 1 |
| Yoo, JW | 1 |
| Noebels, JL | 1 |
| Peterson, DW | 1 |
| Collins, JF | 1 |
| Bradford, HF | 1 |
| Dudek, FE | 5 |
| Wuarin, JP | 3 |
| Tasker, JG | 2 |
| Kim, YI | 3 |
| Peacock, WJ | 4 |
| Zhang, CL | 1 |
| Gloveli, T | 2 |
| Heinemann, U | 7 |
| Fueta, Y | 1 |
| Siniscalchi, A | 2 |
| Tancredi, V | 2 |
| Stasheff, SF | 2 |
| Mott, DD | 1 |
| Wilson, WA | 3 |
| Empson, RM | 2 |
| Jefferys, JG | 4 |
| Lahtinen, H | 1 |
| Ylinen, A | 1 |
| Hyvönen, M | 1 |
| Sirviö, J | 1 |
| Miettinen, R | 1 |
| Riekkinen, PJ | 1 |
| Yamada, N | 1 |
| Bilkey, DK | 1 |
| Piguet, P | 1 |
| Leschinger, A | 1 |
| Stabel, J | 1 |
| Igelmund, P | 1 |
| Gaiarsa, JL | 1 |
| Zagrean, L | 1 |
| Ben-Ari, Y | 2 |
| Loeb, C | 2 |
| Patrone, A | 2 |
| Besio, G | 2 |
| Balestrino, M | 2 |
| Mainardi, P | 2 |
| Schneiderman, JH | 2 |
| Sterling, CA | 1 |
| Luo, R | 1 |
| Scharfman, HE | 1 |
| Müller, M | 1 |
| Gähwiler, BH | 1 |
| Rietschin, L | 1 |
| Thompson, SM | 1 |
| Gean, PW | 4 |
| Chang, FC | 2 |
| Hung, CR | 1 |
| Watts, AE | 1 |
| Smith, SE | 1 |
| al-Zubaidy, ZA | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 3 |
| Isokawa, M | 2 |
| Fried, I | 1 |
| De Sarro, G | 3 |
| De Sarro, A | 2 |
| Ammendola, D | 1 |
| Patel, S | 3 |
| Calabresi, P | 1 |
| Mercuri, NB | 1 |
| Bernardi, G | 1 |
| Rodríguez-Moreno, A | 1 |
| Herreras, O | 1 |
| Lerma, J | 1 |
| Patrylo, PR | 1 |
| Rutecki, PA | 1 |
| Yang, Y | 1 |
| Shoji, Y | 1 |
| Tanaka, E | 2 |
| Yamamoto, S | 1 |
| Maeda, H | 1 |
| Higashi, H | 2 |
| Langosch, JM | 1 |
| Repp, M | 1 |
| Berger, M | 1 |
| Walden, J | 1 |
| Wlaź, P | 1 |
| DeFazio, T | 1 |
| Kapur, A | 1 |
| Haberly, LB | 1 |
| DeLorenzo, RJ | 1 |
| Pal, S | 1 |
| Sombati, S | 1 |
| Faingold, C | 1 |
| Casebeer, D | 1 |
| Standley, CA | 1 |
| Borck, C | 1 |
| Egorov, AV | 1 |
| Schmitz, D | 1 |
| Müller, W | 1 |
| Telfeian, AE | 1 |
| Connors, BW | 1 |
| Xiong, ZQ | 1 |
| Stringer, JL | 1 |
| DeFazio, RA | 1 |
| Folbergrová, J | 1 |
| Haugvicová, R | 1 |
| Keele, NB | 1 |
| Zinebi, F | 1 |
| Neugebauer, V | 1 |
| Shinnick-Gallagher, P | 2 |
| Galoyan, SM | 1 |
| Fornai, F | 1 |
| Bassi, L | 1 |
| Gesi, M | 1 |
| Giorgi, FS | 1 |
| Guerrini, R | 1 |
| Bonaccorsi, I | 1 |
| Alessandrì, MG | 1 |
| Leresche, N | 1 |
| Asprodini, E | 1 |
| Emri, Z | 1 |
| Cope, DW | 1 |
| Crunelli, V | 1 |
| Sanna, PP | 1 |
| Berton, F | 1 |
| Cammalleri, M | 1 |
| Tallent, MK | 1 |
| Siggins, GR | 1 |
| Bloom, FE | 1 |
| Francesconi, W | 1 |
| Luhmann, HJ | 1 |
| Dzhala, VI | 1 |
| Dhillon, A | 1 |
| Jones, RS | 4 |
| Gutiérrez, R | 1 |
| Ravizza, T | 1 |
| Moneta, D | 1 |
| Bottazzi, B | 1 |
| Peri, G | 1 |
| Garlanda, C | 1 |
| Hirsch, E | 1 |
| Richards, GJ | 1 |
| Mantovani, A | 1 |
| Vezzani, A | 1 |
| Woodhall, G | 1 |
| Evans, DI | 1 |
| Sancini, G | 1 |
| Franceschetti, S | 1 |
| Lavazza, T | 1 |
| Panzica, F | 1 |
| Cipelletti, B | 1 |
| Frassoni, C | 1 |
| Spreafico, R | 1 |
| Acampora, D | 1 |
| Avanzini, G | 1 |
| Gorji, A | 2 |
| Jauch, R | 1 |
| Windmüller, O | 1 |
| Lehmann, TN | 1 |
| Gabriel, S | 1 |
| Avshalumov, MV | 1 |
| Rice, ME | 1 |
| Cook, CJ | 1 |
| Devine, CE | 1 |
| Tavener, A | 1 |
| Gilbert, KV | 1 |
| Virgili, M | 1 |
| Migani, P | 1 |
| Contestabile, A | 1 |
| Barnabei, O | 1 |
| Williamson, R | 3 |
| Wheal, HV | 4 |
| Shin, C | 1 |
| Tamaki, Y | 1 |
| Wilson, JT | 1 |
| Butler, L | 1 |
| Sakaguchi, T | 1 |
| Gale, K | 1 |
| Zhong, P | 1 |
| Miller, LP | 1 |
| Murray, TF | 1 |
| Lee, WL | 3 |
| Hwa, GG | 2 |
| Oliver, A | 1 |
| Villemure, JG | 2 |
| Nishi, S | 1 |
| Bawin, SM | 1 |
| Satmary, WM | 1 |
| Mahoney, MD | 1 |
| Adey, WR | 1 |
| Mello, LE | 1 |
| Simpson, LH | 1 |
| Drapeau, C | 1 |
| Louvel, J | 1 |
| Pumain, R | 1 |
| Olivier, A | 1 |
| Urban, L | 1 |
| Aitken, PG | 1 |
| Friedman, A | 2 |
| Somjen, GG | 1 |
| Lambert, JD | 1 |
| Watson, GB | 2 |
| Lanthorn, TH | 2 |
| Shupliakov, OV | 1 |
| Veskov, R | 1 |
| Veselkin, NP | 1 |
| Rakich, L | 1 |
| Cepeda, C | 1 |
| Walsh, JP | 1 |
| Buchwald, NA | 1 |
| Chou, SM | 1 |
| Dreier, JP | 1 |
| Millan, MH | 1 |
| Wardley-Smith, B | 1 |
| Dürmüller, N | 1 |
| Peeters, BW | 1 |
| van Rijn, CM | 1 |
| Vossen, JM | 1 |
| Coenen, AM | 1 |
| Rader, RK | 1 |
| McBain, CJ | 1 |
| Boden, P | 1 |
| Hill, RG | 1 |
| Nakanishi, H | 1 |
| Kamata, O | 1 |
| Katsuda, N | 1 |
| Anderson, WW | 2 |
| Clark, S | 1 |
| MacDonald, JF | 1 |
| Slater, NT | 1 |
| Stelzer, A | 1 |
| Galvan, M | 1 |
| Herron, CE | 1 |
| Collingridge, GL | 2 |
| Ashwood, TJ | 2 |
| Baldino, F | 1 |
| Wolfson, B | 1 |
| Gutnick, MJ | 1 |
| King, GL | 1 |
| Dingledine, R | 1 |
| Swartzwelder, HS | 1 |
| Sagratella, S | 1 |
| Frank, C | 1 |
| de Carolis, AS | 1 |
| Stone, TW | 1 |
| Aram, JA | 1 |
| Lodge, D | 1 |
| Meldrum, B | 1 |
| Millan, M | 1 |
| Kiese, K | 1 |
| Jablonski, J | 1 |
| Hackenbracht, J | 1 |
| Wrosch, JK | 1 |
| Groemer, TW | 1 |
| Kornhuber, J | 1 |
| Blümcke, I | 1 |
| Kobow, K | 1 |
| Nichols, J | 1 |
| Perez, R | 1 |
| Wu, C | 1 |
| Adelson, PD | 1 |
| Anderson, T | 1 |
| Lopantsev, V | 1 |
| Both, M | 1 |
| Draguhn, A | 1 |
| Ketzef, M | 1 |
| Kahn, J | 1 |
| Weissberg, I | 1 |
| Becker, AJ | 1 |
| Gitler, D | 1 |
| Albensi, BC | 1 |
| Ata, G | 1 |
| Schmidt, E | 1 |
| Waterman, JD | 1 |
| Janigro, D | 1 |
| Rüschenschmidt, C | 1 |
| Schwarz, M | 1 |
| Siep, E | 1 |
| Ebner, A | 1 |
| Pannek, HW | 1 |
| Tuxhorn, I | 1 |
| Wolf, P | 1 |
| Thuault, SJ | 1 |
| Calver, AR | 1 |
| Mangan, PS | 1 |
| Scott, CA | 1 |
| Williamson, JM | 1 |
| Gee, VJ | 1 |
| Sheardown, MJ | 1 |
| Newberry, NR | 1 |
1 review available for 2-amino-5-phosphonovalerate and Aura
| Article | Year |
|---|---|
Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Disease Su | 1988 |
133 other studies available for 2-amino-5-phosphonovalerate and Aura
| Article | Year |
|---|---|
NMDA Receptor GluN2 Subtypes Control Epileptiform Events in the Hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; CA1 Region, Hippocampal; Dentat | 2018 |
Impact of protein kinase C activation on epileptiform activity in the hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; | 2008 |
Independent epileptiform discharge patterns in the olfactory and limbic areas of the in vitro isolated Guinea pig brain during 4-aminopyridine treatment.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Brain; Cerebral Cortex; Entorhinal Cortex; Ep | 2010 |
Intracerebroventricularly administered lipopolysaccharide enhances spike-wave discharges in freely moving WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cyt | 2011 |
The afterhyperpolarizing potential following a train of action potentials is suppressed in an acute epilepsy model in the rat Cornu Ammonis 1 area.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; CA1 R | 2012 |
Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Adult; Animals; Axons; Computer Simulation; Cortical | 2012 |
Comparison of spontaneous and evoked epileptiform activity in three in vitro epilepsy models.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicucul | 2002 |
Spontaneous epileptiform activity mediated by GABA(A) receptors and gap junctions in the rat hippocampal slice following long-term exposure to GABA(B) antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carbonic Anhydrase Inhibitors; Electric Stimulation; Electroph | 2002 |
Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Chronic Disease; Cortical Spreading Depression; D | 2003 |
Different reactions of control and epileptic rats to administration of APV or muscimol on thalamic or CA3-induced CA1 responses.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Epilepsy; Male; Muscimol; Rats; Rats, Sprag | 2003 |
Regulation of epileptiform activity in hippocampus by nicotinic acetylcholine receptor activation.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Action Potentials; Analysis of Variance; Animals; Bicu | 2003 |
Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, N | 2004 |
Glutamate transporters regulate excitability in local networks in rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Bicuculline; | 2004 |
Model of frequent, recurrent, and spontaneous seizures in the intact mouse hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; A | 2004 |
Suppression of excitatory synaptic transmission can facilitate low-calcium epileptiform activity in the hippocampus in vivo.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cadmium; Calcium; Chelating Agents; Egtazic Acid; Epilepsy; Ex | 2004 |
Cortical epileptic afterdischarges in immature rats are differently influenced by NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dizocilpine Maleate; Electric Stimulation; Ep | 2005 |
Evidence for the perirhinal cortex as a requisite component in the seizure network following seizure repetition in an inherited form of generalized clonic seizures.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Action Potentials; Analysis of Variance; Animals; | 2005 |
Greater contribution of N-methyl-D-aspartic acid receptors in ventral compared to dorsal hippocampal slices in the expression and long-term maintenance of epileptiform activity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsy | 2005 |
Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals | 2005 |
Stereoselective effects of the novel anticonvulsant lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetamides; Anim | 2006 |
The antiepileptic activity of JSTX-3 is mediated by N-methyl-D-aspartate receptors in human hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Adolescent; Adult; Anticonvulsants; Child; Electroph | 2005 |
Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Animals, Newborn; Bicuculline; Dose-Respons | 2006 |
Postnatal development of a new type of epileptiform activity in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; | 2006 |
Cellular mechanisms underlying antiepileptic effects of low- and high-frequency electrical stimulation in acute epilepsy in neocortical brain slices in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Analysis of Va | 2007 |
Masking epilepsy by combining two epilepsy genes.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Calcium Channel Blockers; Calcium Channels, N-Typ | 2007 |
The kindled amygdala model of epilepsy: anticonvulsant action of amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminobutyrates; Amygdala; Animals; Anticonvulsants; Epilep | 1983 |
Neurophysiology of neocortical slices resected from children undergoing surgical treatment for epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Adolescent; Cerebral Cortex; Child; Child, Preschool; Electrophysiology | 1995 |
Effects of NMDA- and AMPA-receptor antagonists on different forms of epileptiform activity in rat temporal cortex slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dextrorphan; Epilepsy; E | 1994 |
Extracellular magnesium and anticonvulsant effects of valproate in young rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Epilepsy; gamma-Aminobutyric Acid; Hippocampu | 1995 |
Axon terminal hyperexcitability associated with epileptogenesis in vitro. II. Pharmacological regulation by NMDA and GABAA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Axons; Baclofen; Culture Techniques; Epilepsy; Evoked Potentia | 1993 |
Synaptic inhibition in primary and secondary chronic epileptic foci induced by intrahippocampal tetanus toxin in the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Electrophysiolo | 1993 |
Preservation of hippocampal NMDA receptors may be crucial for spatial learning after epileptic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cognition Disorders; Electric Stimulation; Epilepsy; Glutamate | 1993 |
Induction of trypsin-induced hyperexcitability in the rat hippocampal slice is blocked by the N-methyl-D-aspartate receptor antagonist, MK-801.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Electrophysiology; Epilepsy; Hippocampus; | 1993 |
GABAA- and GABAB-mediated inhibition in the rat dentate gyrus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; E | 1993 |
Pharmacological and electrographic properties of epileptiform activity induced by elevated K+ and lowered Ca2+ and Mg2+ concentration in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Carbachol; Elec | 1993 |
Properties and synaptic mechanisms of bicuculline-induced epileptiform bursts in neocortical slices from children with intractable epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Adolescent; Bicuculline; Cerebral Cortex; Child; Child, Preschool; Cult | 1993 |
Neonatal irradiation prevents the formation of hippocampal mossy fibers and the epileptic action of kainate on rat CA3 pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicucu | 1994 |
The antiepileptic effect of low-dose amino-phosphono-valeric acid (APV) is not enhanced by phosphatidylserine association.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Drug Synergism; Electroencep | 1993 |
Hippocampal plasticity following epileptiform bursting produced by GABAA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Epilepsy; Evoked Potentials; GABA Antago | 1994 |
EPSPs of dentate gyrus granule cells during epileptiform bursts of dentate hilar "mossy" cells and area CA3 pyramidal cells in disinhibited rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Atropine; Epilepsy; Evok | 1994 |
Reversible loss of dendritic spines and altered excitability after chronic epilepsy in hippocampal slice cultures.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicucu | 1993 |
Use-dependent modification of a slow NMDA receptor-mediated synaptic potential in rat amygdalar slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amygdala; Animals; Bicuculline; Electrophysiology; E | 1993 |
Epileptic focus induced in rat by intrahippocampal cholera toxin: neuronal properties in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Baclo | 1993 |
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Var | 1993 |
Extracellular slow negative transient in the dentate gyrus of human epileptic hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; Adult; Bicuculline; Dentate Gyrus; Electric Stimulation; Electroencepha | 1996 |
Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Drug Administration Schedule; Drug Tolerance; | 1996 |
Epileptiform discharge induced by 4-aminopyridine in magnesium-free medium in neocortical neurons: physiological and pharmacological characterization.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, | 1997 |
Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Cells, Cult | 1997 |
Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysi | 1998 |
Ictal epileptiform activity in the CA3 region of hippocampal slices produced by pilocarpine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electrophysiology; Epilepsy; Extracellular Space; GABA Agonist | 1998 |
Mechanisms underlying the enhancement of excitatory synaptic transmission in basolateral amygdala neurons of the kindling rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Baclofen; Bicu | 1998 |
Effects of the atypical antidepressant trimipramine on field potentials in the low Mg2+-model in guinea pig hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Antidepressive Agents, Tricyclic; Calcium C | 1998 |
Anti-convulsant and adverse effects of the glycineB receptor ligands, D-cycloserine and L-701,324: comparison with competitive and non-competitive N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Antimetabolites; Avoidance Learning; Binding, | 1998 |
Excitability changes in freeze-induced neocortical microgyria.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Brain; | 1998 |
'Dormant' inhibitory neurons: do they exist and what is their functional impact?
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; C | 1998 |
Duration of NMDA-dependent synaptic potentiation in piriform cortex in vivo is increased after epileptiform bursting.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; | 1998 |
Prolonged activation of the N-methyl-D-aspartate receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Benzoates; Calcium; Cells, Cultured; Dizocil | 1998 |
Modulation of the audiogenic seizure network by noradrenergic and glutamatergic receptors of the deep layers of superior colliculus.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Adrenergic alpha-Agonists; Animals; Epilepsy; Exc | 1999 |
N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Conv | 1999 |
Seizure-like events in disinhibited ventral slices of adult rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials | 1999 |
Carbachol-induced changes in excitability and [Ca2+]i signalling in projection cells of medial entorhinal cortex layers II and III.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Afferent Pathways; Animals; Calcium; Calcium Signali | 1999 |
Epileptiform propagation patterns mediated by NMDA and non-NMDA receptors in rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dose-Response Relationsh | 1999 |
Cesium induces spontaneous epileptiform activity without changing extracellular potassium regulation in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Cesium; | 1999 |
Alterations in NMDA receptors in a rat model of cortical dysplasia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Cortex; Epilepsy; Evoked Potentials; Excitator | 2000 |
Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Cerebral Cortex; Disease Models, Animal; Dizocilp | 2000 |
Epileptogenesis up-regulates metabotropic glutamate receptor activation of sodium-calcium exchange current in the amygdala.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Calcium; Dose- | 2000 |
Long-lasting potentiation of epileptiform bursts by group I mGluRs is NMDA receptor independent.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Convulsants; Epilepsy; Excitatory Amino Aci | 2000 |
Similar increases in extracellular lactic acid in the limbic system during epileptic and/or olfactory stimulation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Convulsants; Denervation; Dose-Response Relationship, Drug; Ep | 2000 |
Somatostatin inhibits GABAergic transmission in the sensory thalamus via presynaptic receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; C | 2000 |
A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Electrophysiology; Enzyme Inhibitors; Epileps | 2000 |
Generation and propagation of 4-AP-induced epileptiform activity in neonatal intact limbic structures in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potential | 2000 |
Laminar differences in recurrent excitatory transmission in the rat entorhinal cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Entor | 2000 |
Kindling induces transient fast inhibition in the dentate gyrus--CA3 projection.
Topics: 2-Amino-5-phosphonovalerate; Animals; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsy | 2001 |
Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.
Topics: 2-Amino-5-phosphonovalerate; Animals; C-Reactive Protein; Epilepsy; Excitatory Amino Acid Agonists; | 2001 |
NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoreceptors; Calcium; Entorhinal Cortex; Epilepsy; Excitator | 2001 |
Potentially epileptogenic dysfunction of cortical NMDA- and GABA-mediated neurotransmission in Otx1-/- mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cell | 2001 |
Low concentration of DL-2-amino-5-phosphonovalerate induces epileptiform activity in guinea pig hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Culture Techniques; Dose-Response Relationship, Drug; Electroe | 2001 |
Effects of barium, furosemide, ouabaine and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) on ionophoretically-induced changes in extracellular potassium concentration in hippocampal slices from rats and from patients with epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anesthetics, Local; A | 2002 |
NMDA receptor activation mediates hydrogen peroxide-induced pathophysiology in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Hi | 2002 |
Single-electrode voltage-clamp analysis of the N-methyl-D-aspartate component of synaptic responses in neocortical slices from children with intractable epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Aging; Bicuculline; C | 1992 |
Contribution of amino acid transmitters to epileptiform activity and reflex suppression in electrically head stunned sheep.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Baclofen; Bicuculline; Blinking; | 1992 |
Protection from kainic acid neuropathological syndrome by NMDA receptor antagonists: effect of MK-801 and CGP 39551 on neurotransmitter and glial markers.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Epilepsy; Kainic Acid; Male; Neuroglia; N | 1992 |
The contribution of AMPA and NMDA receptors to graded bursting activity in the hippocampal CA1 region in an acute in vitro model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Epilepsy; H | 1992 |
NMDA-receptor mediated electrical epileptogenesis in the organotypic culture of rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Epilepsy; Hippocampus; Organ Culture Tec | 1992 |
Excitatory neurotransmitters in the lateral habenula and pedunculopontine nucleus of rat modulate limbic seizures induced by pilocarpine.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Electroencepha | 1992 |
Amino acid neurotransmitter interactions in 'area tempestas': an epileptogenic trigger zone in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Am | 1992 |
Initiation of epileptiform activity by excitatory amino acid receptors in the disinhibited rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cereb | 1991 |
Bicuculline-induced epileptogenesis in the human neocortex maintained in vitro.
Topics: 2-Amino-5-phosphonovalerate; Bicuculline; Cerebral Cortex; Electric Stimulation; Epilepsy; Evoked Po | 1991 |
Synaptic responses of guinea pig cingulate cortical neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; E | 1991 |
Transition from normal to epileptiform activity in kindled rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Cortical Spreading Depression; Electric Sti | 1991 |
NMDA receptor-mediated excitability in dendritically deformed dentate granule cells in pilocarpine-treated rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dendrites; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; I | 1991 |
The contribution of non-NMDA and NMDA receptors to graded bursting activity in the CA1 region of the hippocampus in a chronic model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Chronic Dis | 1991 |
Epileptiform activity induced by low extracellular magnesium in the human cortex maintained in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Cerebral Corte | 1991 |
Excitatory synaptic involvement in epileptiform bursting in the immature rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Cerebral Cortex; | 1991 |
An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Electric Stimulation; Epilepsy; Hippocampus; Humans; | 1990 |
The role of excitatory amino acid receptors in the propagation of epileptiform discharges from the entorhinal cortex to the dentate gyrus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuc | 1990 |
NMDA receptor antagonists attenuate a portion of the penicillin-induced epileptiform burst.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Epilepsy; Hippocampus; In Vitro | 1990 |
Effect of APV and ketamine on epileptiform activity in the CA1 and CA3 regions of the hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Epilepsy; Hippocampus; Ketamine; Male; Neurons; Rats; Rats, In | 1990 |
[Antagonist of NMDA receptor blocks epileptiform discharges in spinal motor neurons of the frog].
Topics: 2-Amino-5-phosphonovalerate; Animals; Epilepsy; In Vitro Techniques; Membrane Potentials; Motor Neur | 1990 |
Synaptic transmission in human neocortex removed for treatment of intractable epilepsy in children.
Topics: 2-Amino-5-phosphonovalerate; Adolescent; Bicuculline; Child; Child, Preschool; Epilepsy; Female; GAB | 1990 |
The excitatory amino acid antagonist amino-phosphono-valeric acid (APV) provides protection against penicillin-induced epileptic activity in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electroencephalography; Epilepsy; Male; Motor Activity; Penici | 1990 |
Epileptiform activity induced by 4-aminopyridine in rat amygdala neurons: the involvement of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animal | 1990 |
Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Electrophysiology; Epilepsy; Hippocampus; In | 1990 |
NMDA receptor-independent epileptiform activity induced by magnesium-free solution in rat amygdala neurons is blocked by CNQX.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Culture Media; | 1990 |
The high pressure neurological syndrome in genetically epilepsy prone rats: protective effect of 2-amino-7-phosphono heptanoate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Atmospheric Pressure; Epilepsy; Female; Male; Myo | 1991 |
Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain; Disease Models, Animal; Dos | 1990 |
Epileptiform activity in vitro can produce long-term synaptic failure and persistent neuronal depolarization.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Epilepsy; Hippocampus; In Vitr | 1989 |
Rat hippocampal slices 'in vitro' display spontaneous epileptiform activity following long-term organotypic culture.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Culture Techniques; Epilepsy; Hippocampus; | 1989 |
2-amino-5-phosphonovaleric acid blocks induction of an epileptiform discharge following a brief hypoxic episode in the hippocampal slices prepared from dietary Mg-deficient mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Diet; Epilepsy; Hippocampus; Hypoxia; In Vitr | 1989 |
NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease | 1989 |
Excitatory amino acid blockers differentially affect bursting of in vitro hippocampal neurons in two pharmacological models of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Epilepsy; Guinea Pigs; Hippocampus; In Vitr | 1989 |
Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vitro hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Epilepsy; Guinea Pigs; Hippocampus; In V | 1985 |
A selective N-methyl-D-aspartate antagonist depresses epileptiform activity in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Epilepsy; Evoked Potentials; Female; Folic Acid A | 1985 |
Extracellular studies on the role of N-methyl-D-aspartate receptors in epileptiform activity recorded from the kainic acid-lesioned hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Epilepsy; Hippocampus; In Vitro Techniques; K | 1986 |
An N-methyl-D-aspartate (NMDA) receptor antagonist reduces bicuculline-induced depolarization shifts in neocortical explant cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Cerebral Corte | 1986 |
Evidence for the activation of the N-methyl-D-aspartate receptor during epileptiform discharge.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Anticonvulsants; Epilepsy; Evoked Potential | 1986 |
The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Electric Stimulation; Electrophysiology; Epilep | 1987 |
Effects of ketamine and (+)cyclazocine on 4-aminopyridine and "magnesium free" epileptogenic activity in hippocampal slices of rats.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Aminopyridines; Animals; Aspartic Acid; Cyclazocine; E | 1987 |
The expression of N-methyl-D-aspartate-receptor-mediated component during epileptiform synaptic activity in hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Anticonvulsants; Epilepsy; Hippocampus; In | 1987 |
Comparison of kynurenic acid and 2-APV suppression of epileptiform activity in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Electrophysiology; Epilepsy; | 1988 |
Epileptiform activity induced by alkalosis in rat neocortical slices: block by antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Alkalosis; Animals; Aspartic Acid; Cerebral Cortex; Epilepsy; In Vitro | 1987 |
Epileptiform activity induced by magnesium-free solution in slices of rat amygdala: antagonism by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Epilepsy; In Vitro Techniques; Magn | 1988 |
Low-magnesium epilepsy in rat hippocampal slices: inhibitory postsynaptic potentials in the CA1 subfield.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebrospinal Fluid; Electric Stimulation; Electrophysiology; | 1988 |
Epileptiform events induced by GABA-antagonists in entorhinal cortical cells in vitro are partly mediated by N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Bicuculline; Cerebral Cortex; Epilepsy; In | 1988 |
Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons.
Topics: Action Potentials; Animals; Animals, Newborn; Cells, Cultured; DNA Methylation; Epigenesis, Genetic; | 2017 |
Traumatic brain injury induces rapid enhancement of cortical excitability in juvenile rats.
Topics: Animals; Animals, Newborn; Biophysics; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Elec | 2015 |
Rapid plasticity at inhibitory and excitatory synapses in the hippocampus induced by ictal epileptiform discharges.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biophysics; Calcium; Electric Stimulation; Epilepsy; | 2009 |
Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice.
Topics: 4-Aminopyridine; Age Factors; Animals; Bicuculline; Brain; Convulsants; Electric Stimulation; Electr | 2011 |
Activation of long-term synaptic plasticity causes suppression of epileptiform activity in rat hippocampal slices.
Topics: Animals; Bicuculline; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation | 2004 |
Characterization of a fast transient outward current in neocortical neurons from epilepsy patients.
Topics: Adolescent; Adult; Anesthetics, Local; Anti-Arrhythmia Agents; Cadmium; Child, Preschool; Epilepsy; | 2004 |
Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices expressing a C-terminal truncated GABA(B2) receptor subunit.
Topics: 4-Aminopyridine; Animals; Bicuculline; Drug Interactions; Electric Stimulation; Embryo, Mammalian; E | 2005 |
Aberrant neuronal physiology in the basal nucleus of the amygdala in a model of chronic limbic epilepsy.
Topics: Action Potentials; Amygdala; Animals; Disease Models, Animal; Electric Stimulation; Epilepsy; Excita | 2000 |
Chlormethiazole inhibits epileptiform activity by potentiating GABA(A) receptor function.
Topics: Action Potentials; Animals; Bicuculline; Cerebral Cortex; Chlormethiazole; Dose-Response Relationshi | 2000 |