2-amino-5-phosphonovalerate has been researched along with Ataxia in 8 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid (CGP 37849) was found to produce a phencyclidine (PCP)-like behavioral syndrome (ataxia, locomotion, stereotypies) in amygdala-kindled rats, whereas the amphetamine-like behavioral alterations of the syndrome (locomotion, stereotypies) were only infrequently seen in nonkindled rats." | 3.68 | The novel competitive N-methyl-D-aspartate (NMDA) antagonist CGP 37849 preferentially induces phencyclidine-like behavioral effects in kindled rats: attenuation by manipulation of dopamine, alpha-1 and serotonin1A receptors. ( Hönack, D; Löscher, W, 1991) |
| "When nimodipine was given before the motor task learning and ethanol after the practice sessions, the tolerance to the ataxic effect of ethanol was increased." | 1.31 | Differential effects of a dihydropyridine calcium channel antagonist on the components of ethanol tolerance. ( Little, HJ; Smith, JW, 2000) |
| "5-5 mg/kg, CGP 37849 potentiated the adverse effects but not the anticonvulsant activity of 50 mg/kg valproate." | 1.29 | Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats. ( Hönack, D; Löscher, W, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nam, HW | 1 |
| Lee, MR | 1 |
| Hinton, DJ | 1 |
| Choi, DS | 1 |
| Rabbani, M | 1 |
| Wright, EJ | 1 |
| Little, HJ | 2 |
| Löscher, W | 3 |
| Hönack, D | 3 |
| Smith, JW | 1 |
| Marco, LA | 1 |
| Joshi, RS | 1 |
| Chronister, RB | 1 |
| Manallack, DT | 1 |
| Lodge, D | 1 |
| Beart, PM | 1 |
8 other studies available for 2-amino-5-phosphonovalerate and Ataxia
| Article | Year |
|---|---|
Reduced effect of NMDA glutamate receptor antagonist on ethanol-induced ataxia and striatal glutamate levels in mice lacking ENT1.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Corpus Striatum; Equilibrative Nucleoside Transporter | 2010 |
Tolerance to competitive NMDA antagonists, but no crosstolerance with barbiturates.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Drug Tolerance; | 1995 |
Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Ataxia; Female; Kindling, Neurologi | 1993 |
Differential effects of a dihydropyridine calcium channel antagonist on the components of ethanol tolerance.
Topics: 2-Amino-5-phosphonovalerate; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Ataxia; | 2000 |
Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Dizo | 1991 |
The novel competitive N-methyl-D-aspartate (NMDA) antagonist CGP 37849 preferentially induces phencyclidine-like behavioral effects in kindled rats: attenuation by manipulation of dopamine, alpha-1 and serotonin1A receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Dose-Response R | 1991 |
Effects of MK-801, a non-competitive NMDA antagonist, on linguopharyngeal events in rats.
Topics: 2-Amino-5-phosphonovalerate; Anesthesia; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Fem | 1991 |
Subchronic administration of MK-801 in the rat decreases cortical binding of [3H]D-AP5, suggesting down-regulation of the cortical N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Ataxia; Cerebral Cortex; Dibenzocycloheptenes | 1989 |