2-amino-5-phosphonovalerate has been researched along with Apnea in 4 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Apnea: A transient absence of spontaneous respiration.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The intra-common carotid artery injection of NMDA (4 mg/kg) induced transient expiratory apnea followed by a brief and variably occurring period of breathing at reduced tidal volume." | 7.73 | Non-vagal apnea evoked by intra-common carotid artery injection of N-methyl-D-aspartic acid (NMDA) in anesthetized rats. ( Chrapusta, SJ; Kaczyńska, K; Szereda-Przestaszewska, M, 2006) |
| "Respiratory disturbance, including apnea, can be induced by microinjection of glutamate into the intertrigeminal region (ITR) of the lateral pons, a region that is anatomically coupled to both the dorsal and ventral respiratory groups of the medulla." | 3.74 | Effects of intertrigeminal region NMDA and non-NMDA receptors on respiratory responses in rats. ( Carley, DW; Radulovacki, M; Saponjic, J; Stoiljkovic, M, 2007) |
| " The intra-common carotid artery injection of NMDA (4 mg/kg) induced transient expiratory apnea followed by a brief and variably occurring period of breathing at reduced tidal volume." | 3.73 | Non-vagal apnea evoked by intra-common carotid artery injection of N-methyl-D-aspartic acid (NMDA) in anesthetized rats. ( Chrapusta, SJ; Kaczyńska, K; Szereda-Przestaszewska, M, 2006) |
| " Activation of NMDA receptors at the ventrolateral nucleus of the tractus solitarius with bilateral microinjection of NMDA, 39 pmol, produced a large increase in expiratory duration (+11 +/- 3 s, n = 8), and apnea during the expiratory phase of the respiratory cycle in half of the animals studied." | 3.69 | NMDA receptors are involved at the ventrolateral nucleus tractus solitarii for termination of inspiration. ( Berger, I; Gillis, RA; Kelly, M; Magee, S; McManigle, JE; Norman, WP; Panico, WH; Taveira DaSilva, AM; Vitagliano, S, 1995) |
| "Three glutamic acid analogues, N-methyl-D-aspartic (NMDA), quisqualic (QQ), and kainic (KAI) acids were applied topically to the ventral surface of the medulla (VMS) in paralyzed, vagotomized and carotid sinus denervated cats hyperventilated to apnea." | 3.67 | Respiratory and vasomotor effects of excitatory amino acid on ventral medullary surface. ( Cherniack, NS; Mitra, J; Overholt, JL; Prabhakar, NR, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Radulovacki, M | 1 |
| Stoiljkovic, M | 1 |
| Saponjic, J | 1 |
| Carley, DW | 1 |
| Kaczyńska, K | 1 |
| Szereda-Przestaszewska, M | 1 |
| Chrapusta, SJ | 1 |
| Berger, I | 1 |
| Gillis, RA | 1 |
| Vitagliano, S | 1 |
| Panico, WH | 1 |
| Magee, S | 1 |
| Kelly, M | 1 |
| Norman, WP | 1 |
| McManigle, JE | 1 |
| Taveira DaSilva, AM | 1 |
| Mitra, J | 1 |
| Prabhakar, NR | 1 |
| Overholt, JL | 1 |
| Cherniack, NS | 1 |
4 other studies available for 2-amino-5-phosphonovalerate and Apnea
| Article | Year |
|---|---|
Effects of intertrigeminal region NMDA and non-NMDA receptors on respiratory responses in rats.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Apnea; Excitatory Amino Acid Antagonists | 2007 |
Non-vagal apnea evoked by intra-common carotid artery injection of N-methyl-D-aspartic acid (NMDA) in anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Anesthesia; Animals; Apnea; Blood Pressure; Carot | 2006 |
NMDA receptors are involved at the ventrolateral nucleus tractus solitarii for termination of inspiration.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 1995 |
Respiratory and vasomotor effects of excitatory amino acid on ventral medullary surface.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apnea; Aspartic Acid; Blood Pressure; Carotid Sinus; Cats; Fem | 1987 |