2-amino-5-phosphonovalerate has been researched along with Anterior Circulation Transient Ischemic Attack in 24 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Seizures were evoked with pilocarpine (400 mg/kg, i." | 7.70 | The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z, 2000) |
| " Seizures were evoked with bicuculline (3." | 7.70 | The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M, 2000) |
| " Seizures were evoked with pilocarpine (400 mg/kg, i." | 3.70 | The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z, 2000) |
| " Seizures were evoked with bicuculline (3." | 3.70 | The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M, 2000) |
| " The noncompetitive antagonist MK-801 and a glycine-site blocker were equally neuroprotective in both normal and reduced conditions, but there was a significant rightward shift in the dose-response curves of the competitive antagonists APV and CPP and the uncompetitive antagonist memantine." | 1.31 | Reducing conditions significantly attenuate the neuroprotective efficacy of competitive, but not other NMDA receptor antagonists in vitro. ( Eshak, M; Iannotti, F; Pringle, AK; Self, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.67) | 18.7374 |
| 1990's | 14 (58.33) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Lei, Z | 1 |
| Xu, ZC | 1 |
| Ye, H | 1 |
| Jalini, S | 1 |
| Zhang, L | 1 |
| Charlton, M | 1 |
| Carlen, PL | 1 |
| Maier, CM | 1 |
| Sun, GH | 1 |
| Kunis, DM | 1 |
| Giffard, RG | 1 |
| Steinberg, GK | 1 |
| Sauer, D | 2 |
| Weber, E | 1 |
| Lüönd, G | 1 |
| Da Silva, F | 1 |
| Allegrini, PR | 2 |
| Stanimirovic, DB | 1 |
| Micic, DV | 2 |
| Markovic, M | 1 |
| Spatz, M | 2 |
| Mrsulja, BB | 2 |
| Ghribi, O | 1 |
| Callebert, J | 1 |
| Plotkine, M | 1 |
| Boulu, RG | 1 |
| Hori, N | 1 |
| Carpenter, DO | 1 |
| Okada, M | 1 |
| Ueda, H | 1 |
| Kometani, M | 1 |
| Nakao, K | 1 |
| Kohjimoto, Y | 1 |
| Takahashi, I | 1 |
| Tanaka, I | 1 |
| Onitsuka, M | 1 |
| Mihara, S | 1 |
| Yamamoto, S | 1 |
| Shigemori, M | 1 |
| Higashi, H | 1 |
| Martin, RL | 1 |
| Hakuba, N | 1 |
| Koga, K | 1 |
| Shudou, M | 1 |
| Watanabe, F | 1 |
| Mitani, A | 1 |
| Gyo, K | 1 |
| Rejdak, K | 2 |
| Rejdak, R | 2 |
| Stelmasiak, Z | 1 |
| Czuczwar, SJ | 2 |
| Kleinrok, Z | 2 |
| Sieklucka-Dziuba, M | 2 |
| Pringle, AK | 1 |
| Self, J | 1 |
| Eshak, M | 1 |
| Iannotti, F | 1 |
| Lauritzen, M | 1 |
| Hansen, AJ | 2 |
| Nellgård, B | 1 |
| Wieloch, T | 1 |
| Salińska, E | 2 |
| Pluta, R | 2 |
| Puka, M | 1 |
| Lazarewicz, JW | 2 |
| Lobner, D | 1 |
| Lipton, P | 1 |
| Stanimirović, D | 1 |
| Roman, R | 1 |
| Bartkowski, H | 1 |
| Simon, R | 1 |
| Swan, JH | 1 |
| Evans, MC | 1 |
| Meldrum, BS | 1 |
| Benveniste, H | 1 |
| Jørgensen, MB | 1 |
| Diemer, NH | 1 |
24 other studies available for 2-amino-5-phosphonovalerate and Anterior Circulation Transient Ischemic Attack
| Article | Year |
|---|---|
Enhancement of inhibitory synaptic transmission in large aspiny neurons after transient cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Biophysics; | 2009 |
Early ischemia enhances action potential-dependent, spontaneous glutamatergic responses in CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain | 2010 |
Neuroprotection by the N-methyl-D-aspartate receptor antagonist CGP 40116: in vivo and in vitro studies.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Evoked Potential | 1995 |
The competitive NMDA antagonist CGP 40116 permanently reduces brain damage after middle cerebral artery occlusion in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Arteries; Constriction; Glial Fibrillary Acidi | 1995 |
'Therapeutic window's for multiple drug treatment of experimental cerebral ischemia in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Animals; Drug Therapy, Combination; Gerbillinae; Ischemic Attack, Trans | 1994 |
Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Extracellular Spa | 1994 |
Transient ischemia causes a reduction of Mg2+ blockade of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium Channels; Cell Death; Electrophysiology; Glycine; Isch | 1994 |
Neuroprotective effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid in the gerbil model of transient global cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Excitatory Amino Acid Antagonists; Gerbillinae; | 1997 |
Nitric oxide contributes to irreversible membrane dysfunction caused by experimental ischemia in rat hippocampal CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzoates; Cell Membrane; Cobalt; Glucose; Hemoglobins; Hippoc | 1998 |
Block of rapid depolarization induced by in vitro energy depletion of rat dorsal vagal motoneurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bepridil; Brain Stem; Ca | 1999 |
Hearing loss and glutamate efflux in the perilymph following transient hindbrain ischemia in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Animals; Audiometry, Evoked Response; Cerebrovascular Circulation; Coch | 2000 |
The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Brain Chemistry; Car | 2000 |
Reducing conditions significantly attenuate the neuroprotective efficacy of competitive, but not other NMDA receptor antagonists in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; | 2000 |
The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; D | 2000 |
The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cerebral Cortex; Cortical Spreading Depression; D | 1992 |
Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Glucose; Blood Pressure; Body Temperature; Cell Death; D | 1992 |
Application of magnetic resonance imaging to the measurement of neurodegeneration in rat brain: MRI data correlate strongly with histology and enzymatic analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Arteries; Choline O-Acetyltransferase; Clinica | 1992 |
Blockade of N-methyl-D-aspartate-sensitive excitatory amino acid receptors with 2-amino-5-phosphonovalerate reduces ischemia-evoked calcium redistribution in rabbit hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood-Brain Barrier; Calcium; Cerebral Cortex; Electroencephal | 1991 |
Sigma-ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cyclazocine; Dizocilpine Maleate | 1990 |
Excitatory amino acid receptors, oxido-reductive processes and brain oedema following transient ischaemia in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anions; Brain Edema; Female; Gerbillinae; Ischemi | 1990 |
The specific NMDA receptor antagonist AP-7 attenuates focal ischemic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Ischemic Attack, Transient; Kineti | 1989 |
Participation of NMDA-receptors in ischemic changes of calcium homeostasis in rabbit brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Calcium; Female; Hippocampus; Homeostasis; Is | 1989 |
Long-term development of selective neuronal loss and the mechanism of protection by 2-amino-7-phosphonoheptanoate in a rat model of incomplete forebrain ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cell Survival; Ce | 1988 |
Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Extracellular Space; Hippocampus; Ischemic Attack, Tr | 1988 |