2-amino-5-phosphonovalerate has been researched along with Anoxia, Brain in 14 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In an in vitro model of cerebral ischemia we investigated the functional consequences of repeated hypoxias and the potential protective effect of the N-methyl-D-aspartate (NMDA) receptor antagonist D-2-amino-5-phosphonovaleric acid (D-APV) and the calcium channel blocker verapamil in preventing the expression of pathophysiological activity." | 3.68 | Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemia. ( Heinemann, U; Kral, T; Luhmann, HJ; Mittmann, T, 1993) |
| " KA and AMPA were found to be more toxic than either N-methyl-D-aspartate (NMDA), quinolinate, or glutamate, both under normal conditions and under states of energy deprivation." | 1.29 | Kainate toxicity in energy-compromised rat hippocampal slices: differences between oxygen and glucose deprivation. ( Rigor, BM; Schurr, A, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 9 (64.29) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yao, W | 1 |
| Ji, F | 1 |
| Chen, Z | 1 |
| Zhang, N | 1 |
| Ren, SQ | 1 |
| Zhang, XY | 1 |
| Liu, SY | 1 |
| Lu, W | 1 |
| Schurr, A | 2 |
| Payne, RS | 1 |
| Rigor, BM | 2 |
| Sun, MK | 1 |
| Reis, DJ | 1 |
| Nabetani, M | 1 |
| Okada, Y | 1 |
| Khazipov, R | 2 |
| Bregestovski, P | 1 |
| Ben-Ari, Y | 2 |
| Flavin, MP | 1 |
| Yang, Y | 1 |
| Ho, G | 1 |
| Kral, T | 1 |
| Luhmann, HJ | 1 |
| Mittmann, T | 1 |
| Heinemann, U | 1 |
| Jaw, SP | 1 |
| Vuong, QT | 1 |
| Nguyen, M | 1 |
| Kasischke, K | 1 |
| Ludolph, AC | 1 |
| Riepe, MW | 1 |
| Kulik, A | 1 |
| Trapp, S | 1 |
| Ballanyi, K | 1 |
| Dzhala, V | 1 |
| Khalilov, I | 1 |
| Clark, GD | 1 |
| Rothman, SM | 1 |
| Aitken, PG | 1 |
| Balestrino, M | 1 |
| Somjen, GG | 1 |
14 other studies available for 2-amino-5-phosphonovalerate and Anoxia, Brain
| Article | Year |
|---|---|
Glycine exerts dual roles in ischemic injury through distinct mechanisms.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Dose-Response Relationship, Drug; Glucose; Gly | 2012 |
Protection by MK-801 against hypoxia-, excitotoxin-, and depolarization-induced neuronal damage in vitro.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anti-Anxiety | 1995 |
Kainate toxicity in energy-compromised rat hippocampal slices: differences between oxygen and glucose deprivation.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calc | 1993 |
Hypoxic excitation of medullary vasomotor neurons in rats are not mediated by glutamate or nitric oxide.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Oxidoreductases; Animals; Glutamates; Glutamic Acid; Hypoxia | 1993 |
Developmental and regional differences in the vulnerability of rat hippocampal slices to brief and prolonged periods of hypoxia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electrophysiology; Hippocampus; Hypoxia, Brain; In Vitro Techn | 1994 |
Hippocampal inhibitory interneurons are functionally disconnected from excitatory inputs by anoxia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Culture Techniques; Elec | 1993 |
Hypoxic forebrain cholinergic neuron injury: role of glucose, excitatory amino acid receptors and nitric oxide.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine; Cells, Culture | 1993 |
Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Calcium; Calcium Channels; Electrophysiology; | 1993 |
Effects of glutamate receptor antagonists on posthypoxic myoclonus in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Di | 1996 |
NMDA-antagonists reverse increased hypoxic tolerance by preceding chemical hypoxia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antihypertensive Agents; | 1996 |
Ischemia but not anoxia evokes vesicular and Ca(2+)-independent glutamate release in the dorsal vagal complex in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain | 2000 |
Neuronal mechanisms of the anoxia-induced network oscillations in the rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Anesthetics, Local; An | 2001 |
Blockade of excitatory amino acid receptors protects anoxic hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Conductivity; Hippocampus; Hypoxia, Brain; In Vitro T | 1987 |
NMDA antagonists: lack of protective effect against hypoxic damage in CA1 region of hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Female; Hippocampus; Hypoxia, Brain; Membrane Pot | 1988 |