2-amino-5-phosphonovalerate has been researched along with Amyotrophic Lateral Sclerosis in 3 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sen, I | 1 |
| Nalini, A | 1 |
| Joshi, NB | 1 |
| Joshi, PG | 1 |
| Couratier, P | 1 |
| Hugon, J | 1 |
| Sindou, P | 1 |
| Vallat, JM | 1 |
| Dumas, M | 1 |
| Mennini, T | 1 |
| Cagnotto, A | 1 |
| Carvelli, L | 1 |
| Comoletti, D | 1 |
| Manzoni, C | 1 |
| Muzio, V | 1 |
| Rizzi, M | 1 |
| Vezzani, A | 1 |
3 other studies available for 2-amino-5-phosphonovalerate and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Cerebrospinal fluid from amyotrophic lateral sclerosis patients preferentially elevates intracellular calcium and toxicity in motor neurons via AMPA/kainate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Calcium; | 2005 |
Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aged; Amino Acids; Amyotrophic La | 1993 |
Biochemical and pharmacological evidence of a functional role of AMPA receptors in motor neuron dysfunction in mnd mice.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic L | 1999 |