2-amino-5-phosphonovalerate has been researched along with Alcoholism in 5 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "When nimodipine was given before the motor task learning and ethanol after the practice sessions, the tolerance to the ataxic effect of ethanol was increased." | 1.31 | Differential effects of a dihydropyridine calcium channel antagonist on the components of ethanol tolerance. ( Little, HJ; Smith, JW, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jerlhag, E | 1 |
| Egecioglu, E | 1 |
| Dickson, SL | 1 |
| Engel, JA | 1 |
| Rudolph, JG | 1 |
| Walker, DW | 1 |
| Iimuro, Y | 1 |
| Thurman, RG | 1 |
| Crews, FT | 1 |
| Freund, G | 1 |
| Anderson, KJ | 1 |
| Smith, JW | 1 |
| Little, HJ | 1 |
| Roberto, M | 1 |
| Cruz, MT | 1 |
| Gilpin, NW | 1 |
| Sabino, V | 1 |
| Schweitzer, P | 1 |
| Bajo, M | 1 |
| Cottone, P | 1 |
| Madamba, SG | 1 |
| Stouffer, DG | 1 |
| Zorrilla, EP | 1 |
| Koob, GF | 1 |
| Siggins, GR | 1 |
| Parsons, LH | 1 |
5 other studies available for 2-amino-5-phosphonovalerate and Alcoholism
| Article | Year |
|---|---|
Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system.
Topics: 2-Amino-5-phosphonovalerate; Alcoholism; Animals; Benzoxazoles; Dopamine; Ghrelin; Limbic System; Ma | 2011 |
NMDA receptor binding in adult rat brain after several chronic ethanol treatment protocols.
Topics: 2-Amino-5-phosphonovalerate; Alcoholism; Animals; Binding, Competitive; Brain; Brain Mapping; Dizoci | 1997 |
Glutamate receptors in the cingulate cortex, hippocampus, and cerebellar vermis of alcoholics.
Topics: 2-Amino-5-phosphonovalerate; Aged; Alcoholism; Cerebellar Cortex; Dizocilpine Maleate; Excitatory Am | 1999 |
Differential effects of a dihydropyridine calcium channel antagonist on the components of ethanol tolerance.
Topics: 2-Amino-5-phosphonovalerate; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Ataxia; | 2000 |
Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alcoholism; Amygdala; Animals; Body Weight; Central Nervous Sy | 2010 |