2-amino-5-phosphonovalerate has been researched along with Aging in 85 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Curcumin has neuroprotective effect and could enhance memory." | 5.39 | Curcumin rescues aging-related loss of hippocampal synapse input specificity of long term potentiation in mice. ( Cheng, YF; Guo, L; Li, JM; Liu, YS; Wu, QW; Xie, YS; Zhang, J, 2013) |
| "Curcumin has neuroprotective effect and could enhance memory." | 1.39 | Curcumin rescues aging-related loss of hippocampal synapse input specificity of long term potentiation in mice. ( Cheng, YF; Guo, L; Li, JM; Liu, YS; Wu, QW; Xie, YS; Zhang, J, 2013) |
| "Neonatal seizures are associated with a high likelihood of adverse neurological outcomes, including mental retardation, behavioral disorders, and epilepsy." | 1.36 | Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex. ( Holmes, GL; Isaev, D; Isaeva, E; Khazipov, R; Savrasova, A, 2010) |
| "Extracellular levels of endogenous glutamate are relatively high in the developing rabbit retina but nonetheless appear to promote cell survival and developmental processes at concentrations considered toxic in the adult." | 1.30 | N-methyl-D-aspartate-mediated glutamate toxicity in the developing rabbit retina. ( Haberecht, MF; Lo, GJ; Mitchell, CK; Redburn, DA, 1997) |
| "Major seizures were significantly suppressed with the highest dose of AP7 (60 mg/kg) in all groups except 7-day-old rats." | 1.28 | Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate. ( Kulovaná, M; Kusá, R; Mares, P; Velísek, L, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (4.71) | 18.7374 |
| 1990's | 53 (62.35) | 18.2507 |
| 2000's | 23 (27.06) | 29.6817 |
| 2010's | 5 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Broicher, T | 1 |
| Bidmon, HJ | 1 |
| Kamuf, B | 1 |
| Coulon, P | 1 |
| Gorji, A | 1 |
| Pape, HC | 1 |
| Speckmann, EJ | 1 |
| Budde, T | 1 |
| Meng, K | 1 |
| Li, YH | 1 |
| Zhang, L | 1 |
| Li, P | 1 |
| Han, TZ | 1 |
| Isaeva, E | 1 |
| Isaev, D | 1 |
| Savrasova, A | 1 |
| Khazipov, R | 1 |
| Holmes, GL | 1 |
| Cheng, YF | 1 |
| Guo, L | 1 |
| Xie, YS | 1 |
| Liu, YS | 1 |
| Zhang, J | 2 |
| Wu, QW | 1 |
| Li, JM | 1 |
| Ma, CL | 1 |
| Kelly, JB | 1 |
| Wu, SH | 1 |
| Okada, M | 2 |
| Nakanishi, H | 1 |
| Amamoto, T | 1 |
| Urae, R | 1 |
| Ando, S | 1 |
| Yazawa, K | 1 |
| Fujiwara, M | 1 |
| Ohmura, T | 1 |
| Ming, R | 1 |
| Yoshimura, Y | 1 |
| Komatsu, Y | 1 |
| Braga, MF | 1 |
| Aroniadou-Anderjaska, V | 1 |
| Manion, ST | 1 |
| Hough, CJ | 1 |
| Li, H | 1 |
| Yoshimura, H | 2 |
| Kato, N | 3 |
| Sugai, T | 2 |
| Segami, N | 2 |
| Onoda, N | 2 |
| Honjo, M | 1 |
| Kitamura, HW | 1 |
| Hamanaka, H | 1 |
| Watanabe, M | 1 |
| Wada, K | 1 |
| Yamazaki, C | 1 |
| Fujita, SC | 1 |
| Manabe, T | 1 |
| Nukina, N | 1 |
| Skov, J | 1 |
| Andreasen, M | 1 |
| Nedergaard, S | 1 |
| Murphy, GG | 1 |
| Shah, V | 1 |
| Hell, JW | 1 |
| Silva, AJ | 1 |
| Burgard, EC | 1 |
| Hablitz, JJ | 2 |
| Pazzagli, M | 1 |
| Corsi, C | 1 |
| Fratti, S | 1 |
| Pedata, F | 1 |
| Pepeu, G | 1 |
| Rocha, M | 1 |
| Sur, M | 3 |
| Abdul-Razzak, R | 1 |
| Bagust, J | 1 |
| Kerkut, GA | 1 |
| Zona, C | 1 |
| Palma, E | 1 |
| Brancati, A | 1 |
| Avoli, M | 1 |
| Schnupp, JW | 1 |
| King, AJ | 1 |
| Smith, AL | 1 |
| Thompson, ID | 1 |
| Velísek, L | 2 |
| Moshé, SL | 1 |
| Stanton, PK | 1 |
| Luhmann, HJ | 4 |
| Kral, T | 1 |
| Heinemann, U | 1 |
| Ramoa, AS | 1 |
| McCormick, DA | 1 |
| Hofer, M | 1 |
| Prusky, GT | 2 |
| Constantine-Paton, M | 2 |
| Navarro, CE | 1 |
| Cabrera, RJ | 1 |
| Donoso, AO | 1 |
| Serra, M | 1 |
| Ghiani, CA | 1 |
| Foddi, MC | 1 |
| Motzo, C | 1 |
| Biggio, G | 1 |
| Facchinetti, F | 2 |
| Dall'Olio, R | 1 |
| Ciani, E | 2 |
| Sparapani, M | 2 |
| Virgili, M | 2 |
| Contestabile, A | 2 |
| D'Angelo, E | 1 |
| Rossi, P | 1 |
| Taglietti, V | 1 |
| Barb, CR | 1 |
| Campbell, RM | 1 |
| Armstrong, JD | 1 |
| Cox, NM | 1 |
| Fox, K | 5 |
| Schlaggar, BL | 1 |
| Glazewski, S | 1 |
| O'Leary, DD | 2 |
| Norris, CM | 1 |
| Korol, DL | 1 |
| Foster, TC | 1 |
| Zhong, J | 1 |
| Gribkoff, VK | 1 |
| Molinoff, PB | 1 |
| Fleischer-Lambropoulos, E | 1 |
| Kazazoglou, T | 1 |
| Geladopoulos, T | 1 |
| Kentroti, S | 1 |
| Stefanis, C | 1 |
| Vernadakis, A | 1 |
| Marret, S | 1 |
| Gressens, P | 1 |
| Evrard, P | 1 |
| Haberecht, MF | 1 |
| Mitchell, CK | 1 |
| Lo, GJ | 1 |
| Redburn, DA | 1 |
| Li, Z | 1 |
| Massengill, JL | 1 |
| O'Dowd, DK | 1 |
| Smith, MA | 1 |
| Jouvenceau, A | 1 |
| Dutar, P | 1 |
| Billard, JM | 1 |
| Shankar, S | 1 |
| Teyler, TJ | 1 |
| Robbins, N | 1 |
| Caillard, O | 1 |
| McLean, HA | 1 |
| Ben-Ari, Y | 2 |
| Gaïarsa, JL | 1 |
| Lo, YJ | 1 |
| Rao, SC | 1 |
| Sanes, DH | 2 |
| Hamba, M | 1 |
| Karpuk, N | 1 |
| Qü, M | 1 |
| Zilles, K | 1 |
| Golshani, P | 1 |
| Warren, RA | 1 |
| Jones, EG | 1 |
| Binns, KE | 1 |
| Salt, TE | 1 |
| Pinilla, L | 1 |
| Gonzalez, L | 1 |
| Tena-Sempere, M | 1 |
| Dieguez, C | 1 |
| Aguilar, E | 1 |
| Mienville, JM | 1 |
| Pesold, C | 1 |
| Butler, AK | 1 |
| Uryu, K | 1 |
| Rougon, G | 1 |
| Chesselet, MF | 1 |
| Hahm, JO | 1 |
| Cramer, KS | 1 |
| Hafidi, A | 1 |
| Lanjun, G | 1 |
| Diabira, D | 1 |
| Hennou, S | 1 |
| Chevassus-Au-Louis, N | 1 |
| Gozlan, H | 1 |
| Kemp, N | 1 |
| McQueen, J | 1 |
| Faulkes, S | 1 |
| Bashir, ZI | 1 |
| Schwarcz, R | 1 |
| Ceresoli-Borroni, G | 1 |
| Wu, HQ | 1 |
| Rassoulpour, A | 1 |
| Poeggeler, B | 1 |
| Hodgkins, PS | 1 |
| Guidetti, P | 1 |
| Zhu, H | 1 |
| Barr, GA | 1 |
| Partridge, JG | 1 |
| Tang, KC | 1 |
| Lovinger, DM | 1 |
| Ford, H | 1 |
| Ebling, FJ | 1 |
| Hohnke, CD | 1 |
| Oray, S | 1 |
| Futai, K | 1 |
| Matsuyama, K | 1 |
| Takahashi, T | 1 |
| Ikegaya, Y | 1 |
| Koyama, R | 1 |
| Yamada, MK | 1 |
| Nishiyama, N | 1 |
| Matsuki, N | 1 |
| Gibbs, LM | 1 |
| Kendig, JJ | 1 |
| Wuarin, JP | 1 |
| Peacock, WJ | 1 |
| Dudek, FE | 1 |
| Gorter, JA | 1 |
| Veerman, M | 1 |
| Mirmiran, M | 1 |
| Daw, N | 3 |
| Sato, H | 4 |
| Czepita, D | 2 |
| Otis, TS | 1 |
| Mody, I | 1 |
| Simon, DK | 1 |
| Hestrin, S | 1 |
| Prince, DA | 2 |
| Daw, NW | 1 |
| Carmichael, T | 1 |
| Gingerich, R | 1 |
| Artola, A | 1 |
| Singer, W | 2 |
| Sorimachi, M | 1 |
| Nishimura, S | 1 |
| Morita, Y | 1 |
| Lee, WL | 1 |
| Kusá, R | 1 |
| Kulovaná, M | 1 |
| Mares, P | 1 |
| Bode-Greuel, KM | 1 |
| Garthwaite, J | 1 |
| Brodbelt, AR | 1 |
| Kimura, F | 1 |
| Nishigori, A | 1 |
| Shirokawa, T | 1 |
| Tsumoto, T | 1 |
| Abrahamsson, T | 1 |
| Gustafsson, B | 1 |
| Hanse, E | 1 |
| Cui, Y | 1 |
| Cai, R | 1 |
| Pan, Y | 1 |
| Sun, X | 1 |
| Milner, AJ | 1 |
| Cummings, DM | 1 |
| Spencer, JP | 1 |
| Murphy, KP | 1 |
| Yang, S | 1 |
| Qiao, H | 1 |
| Wen, L | 1 |
| Zhou, W | 1 |
| Zhang, Y | 1 |
| Krause, M | 2 |
| Yang, Z | 2 |
| Rao, G | 2 |
| Houston, FP | 1 |
| Barnes, CA | 2 |
| McNaughton, BL | 1 |
| Guo, Y | 1 |
| Sánchez, C | 1 |
| Udin, SB | 1 |
| Boettiger, CA | 1 |
| Doupe, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Seizure Detection in Neonates Using Multimodal Temporary Epidermal Electronics[NCT02451618] | 13 participants (Actual) | Observational | 2015-01-27 | Terminated (stopped due to Trial was discontinued due to inadequate signal from study eeg leads.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for 2-amino-5-phosphonovalerate and Aging
| Article | Year |
|---|---|
Aspartate and glutamate modulation of growth hormone secretion in the pig: possible site of action.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Aspartic Acid; Body Weight; Cells, Cultured; Dose-Respo | 1996 |
84 other studies available for 2-amino-5-phosphonovalerate and Aging
| Article | Year |
|---|---|
Thalamic afferent activation of supragranular layers in auditory cortex in vitro: a voltage sensitive dye study.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Auditory Cortex; | 2010 |
Ca2+-permeable AMPA receptors mediate induction of test pulse depression of naive synapses in rat visual cortical slices at early postnatal stage.
Topics: 2-Amino-5-phosphonovalerate; Adamantane; Aging; Animals; Electric Stimulation; Evoked Potentials; Ex | 2010 |
Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Excitatory Amino Acid Antagonists; Ex | 2010 |
Curcumin rescues aging-related loss of hippocampal synapse input specificity of long term potentiation in mice.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Antioxidants; Calcium Channel Blockers; Curcumin; Elect | 2013 |
AMPA and NMDA receptors mediate synaptic excitation in the rat's inferior colliculus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Excitatory Amino | 2002 |
How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus?
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Arachidonic Acid; Calcium; Calcium Signaling; Caloric R | 2003 |
Age and experience dependence of N-methyl-D-aspartate receptor-independent long-term potentiation in rat visual cortex.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Bicuculline; Darkness; Electric Stimu | 2003 |
Stress impairs alpha(1A) adrenoceptor-mediated noradrenergic facilitation of GABAergic transmission in the basolateral amygdala.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Antagonists; Adr | 2004 |
Age-dependent emergence of oscillatory signal flow between the primary and secondary visual cortices in rat brain slices.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Caffeine; Calcium; Electric Stimulation; Electrophysiol | 2003 |
Age-dependent emergence of a parieto-insular corticocortical signal flow in developing rats.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Caffeine; Central Nervous System Stim | 2004 |
Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Apolipoprotein E4 | 2004 |
Postnatal development of a new type of epileptiform activity in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; | 2006 |
Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Calcium; Calcium Channels, L-Type; Cognition Disorders; | 2006 |
NMDA receptor-mediated components of miniature excitatory synaptic currents in developing rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Cell Differentiation; Culture Techniq | 1993 |
Regulation of extracellular adenosine levels in the striatum of aging rats.
Topics: 2-Amino-5-phosphonovalerate; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; A | 1995 |
Rapid acquisition of dendritic spines by visual thalamic neurons after blockade of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Dendrites; Female; Ferrets; Geniculat | 1995 |
Postnatal changes in the role of NMDA in the isolated spinal cord of the hamster, Mesocricetus auratus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aging; Animals; Cricetinae; In Vitro Techniques; Mag | 1994 |
Age-dependent appearance of synaptic currents in rat neocortical neurons in culture.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Cadmium; Cells, C | 1994 |
NMDA-receptor antagonists disrupt the formation of the auditory space map in the mammalian superior colliculus.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Auditory Pathways; Dizocilpine Maleate; Ferrets; Recept | 1995 |
Age dependence of homosynaptic non-NMDA mediated long-term depression in field CA1 of rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Electric Stimulation; Evoked Potentials; Hippocampus; I | 1993 |
Influence of hypoxia on excitation and GABAergic inhibition in mature and developing rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Cell Hypoxia; Ele | 1993 |
Enhanced activation of NMDA receptor responses at the immature retinogeniculate synapse.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Aging; Animals | 1994 |
Regulation of NMDA receptor mRNA during visual map formation and after receptor blockade.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Cerebral Cortex; Rats; Rats, Sprague-Dawley; Receptors, | 1994 |
Release of 3H-noradrenaline by excitatory amino acids from rat mediobasal hypothalamus and the influence of aging.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Amino Acids; Animals; Glut | 1994 |
NMDA receptor function is enhanced in the hippocampus of aged rats.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; | 1994 |
Long-lasting effects of chronic neonatal blockade of N-methyl-D-aspartate receptor through the competitive antagonist CGP 39551 in rats.
Topics: 2-Amino-5-phosphonovalerate; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Aging; Animals; Animals, Ne | 1994 |
Chronic neonatal blockade of NMDA receptor does not affect developmental polyamine metabolism but results in altered response to the excitotoxic induction of ornithine decarboxylase.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Brain; Cerebellum; Cerebral Cortex; E | 1994 |
Different proportions of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor currents at the mossy fibre-granule cell synapse of developing rat cerebellum.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Bicuculline; Cere | 1993 |
Glutamate receptor blockade at cortical synapses disrupts development of thalamocortical and columnar organization in somatosensory cortex.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Aging; Animals; Animals, Newborn; Cats; Cerebral Cor | 1996 |
Increased susceptibility to induction of long-term depression and long-term potentiation reversal during aging.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Calcium; Disease Susceptibility; In Vitro Techniques; L | 1996 |
Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Base Sequence; Cerebral Cortex; Excit | 1996 |
Stimulation of glutamine synthetase activity by excitatory amino acids in astrocyte cultures derived from aged mouse cerebral hemispheres may be associated with non-N-methyl-D-aspartate receptor activation.
Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1996 |
Arrest of neuronal migration by excitatory amino acids in hamster developing brain.
Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; Animals; Animals, Newborn; Brain; Cell Differentiation; | 1996 |
N-methyl-D-aspartate-mediated glutamate toxicity in the developing rabbit retina.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Cell Death; Cyclic GMP; Dextromethorp | 1997 |
Agrin gene expression in mouse somatosensory cortical neurons during development in vivo and in cell culture.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Agrin; Alternative Splicin | 1997 |
Is activation of the metabotropic glutamate receptors impaired in the hippocampal CA1 area of the aged rat?
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Benzoates; Cycloleucine; Excitatory Amino Acid Agonists | 1997 |
Aging differentially alters forms of long-term potentiation in rat hippocampal area CA1.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Calcium Channels; Calcium Channels, N-Type; Electric St | 1998 |
Ontogenesis of presynaptic GABAB receptor-mediated inhibition in the CA3 region of the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; | 1998 |
Modulation of calcium by inhibitory systems in the developing auditory midbrain.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Aging; Animals | 1998 |
Stimulation-induced responses of the trigeminal caudal neurons in the brainstem preparation isolated from newborn rats.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Aging; Animals; Animals, Newborn; Bicuculline; Brain | 1998 |
Characterization of neuronal migration disorders in neocortical structures. II. Intracellular in vitro recordings.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Brain Diseases; Cell Movement; Evoked | 1998 |
Progression of change in NMDA, non-NMDA, and metabotropic glutamate receptor function at the developing corticothalamic synapse.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; | 1998 |
Experience-dependent changes in the importance of N-methyl-D-aspartate (NMDA) receptors for visual transmission in superior colliculus.
Topics: 2-Amino-5-phosphonovalerate; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animal | 1998 |
Gonadal and age-related influences on NMDA-induced growth hormone secretion in male rats.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; | 1999 |
Low resting potential and postnatal upregulation of NMDA receptors may cause Cajal-Retzius cell death.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Adenosine Triphosphate; Aging; Animals; Cell Death; | 1999 |
N-methyl-D-aspartate receptor blockade affects polysialylated neural cell adhesion molecule expression and synaptic density during striatal development.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Corpus Striatum; Dizocilpine Maleate; Gene Expression R | 1999 |
Pattern formation by retinal afferents in the ferret lateral geniculate nucleus: developmental segregation and the role of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Axonal Transport; Axons; Dizocilpine | 1999 |
Age-dependent failure of axon regeneration in organotypic culture of gerbil auditory midbrain.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Axons; Cell Death | 1999 |
Late embryonic expression of AMPA receptor function in the CA1 region of the intact hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Aging; Animals | 1999 |
Different forms of LTD in the CA1 region of the hippocampus: role of age and stimulus protocol.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Electric Stimulation; Evoked Potentials; Female; Hippoc | 2000 |
Modulation and function of kynurenic acid in the immature rat brain.
Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; Animals; Brain; Dextroamphetamine; Enzyme Inhibitors; E | 1999 |
Naltrexone-precipitated morphine withdrawal in infant rat is attenuated by acute administration of NOS inhibitors but not NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Dizocilpine Maleate; Enzyme Inhibitor | 2000 |
Regional and postnatal heterogeneity of activity-dependent long-term changes in synaptic efficacy in the dorsal striatum.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aging; Analysis of Variance; Animals; Corpus Striatu | 2000 |
Glutamatergic regulation of gonadotropin releasing hormone mRNA levels during development in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid A | 2000 |
Activity-dependent patterning of retinogeniculate axons proceeds with a constant contribution from AMPA and NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Axonal Transport; Axons; Body Patterning; Cholera Toxin | 2000 |
High-fidelity transmission acquired via a developmental decrease in NMDA receptor expression at an auditory synapse.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aging; Animals; Auditory Pathways; Brain Stem; Cochl | 2001 |
Rapid regrowth of hippocampal mossy fibres and preceding maturation of NMDA receptor-mediated neurotransmission.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Carbocyanines; Cell Differentiation; | 2002 |
Substance P and NMDA receptor-mediated slow potentials in neonatal rat spinal cord: age-related changes.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Aging; Analgesics; Animals; Animals, Newborn; Electric | 1992 |
Single-electrode voltage-clamp analysis of the N-methyl-D-aspartate component of synaptic responses in neocortical slices from children with intractable epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Aging; Bicuculline; C | 1992 |
Hippocampal neuronal responsiveness to NMDA agonists and antagonists in the adult rat neonatally treated with MK-801.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Dizocilpine Maleate; Female; Glutamat | 1992 |
The effect of visual experience on development of NMDA receptor synaptic transmission in kitten visual cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Cats; Darkness; E | 1992 |
Modulation of decay kinetics and frequency of GABAA receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Anesthetics, Local; Animal | 1992 |
N-methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Axons; Dihydro-beta-Erythroidine; Dizocilpine Maleate; | 1992 |
Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Electric Stimulat | 1992 |
Dark-rearing delays the loss of NMDA-receptor function in kitten visual cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Cats; Darkness; L | 1991 |
Postnatal maturation of the GABAergic system in rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aging; Animals; Animals, Newborn; Baclofen; Bicucull | 1991 |
Cortisol reduces plasticity in the kitten visual cortex.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Body Weight; Cats; Dominance, Cerebral; Dose-Response R | 1991 |
Developmental changes in the susceptibility to long-term potentiation of neurones in rat visual cortex slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-me | 1991 |
N-methyl-D-aspartate and aspartate raise the cytosolic free calcium concentration by acting upon receptors transiently expressed on immature cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; | 1991 |
Excitatory synaptic involvement in epileptiform bursting in the immature rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Cerebral Cortex; | 1991 |
Transient expression of polysynaptic NMDA receptor-mediated activity during neocortical development.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aging; Animals; Electric Stimulation; In Vitro Techn | 1990 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate.
Topics: 2-Amino-5-phosphonovalerate; Aging; Amino Acids; Animals; Anticonvulsants; Male; Motor Activity; Pen | 1990 |
The development of N-methyl-D-aspartate receptors in cat visual cortex.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Binding, Competitive; Cats; Glutamates; Glutamic Acid; | 1989 |
Synaptic activation of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors in the mossy fibre pathway in adult and immature rat cerebellar slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Aging; Animals | 1989 |
The location and function of NMDA receptors in cat and kitten visual cortex.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Cats; Dose-Response Relationship, Drug; Neurons; Recept | 1989 |
Long-term potentiation and N-methyl-D-aspartate receptors in the visual cortex of young rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aging; Animals; Rats; Rats, Inbred Strains; Receptor | 1989 |
AMPA silencing is a prerequisite for developmental long-term potentiation in the hippocampal CA1 region.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Animals, Newb | 2008 |
Early APV chronic blocked alters experience-dependent plasticity of auditory spatial representation in rat auditory cortical neurons.
Topics: Acoustic Stimulation; Aging; Animals; Auditory Cortex; Auditory Perception; Drug Implants; Excitator | 2010 |
Bi-directional plasticity and age-dependent long-term depression at mouse CA3-CA1 hippocampal synapses.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Dose-Response Relationship, Dru | 2004 |
D-serine enhances impaired long-term potentiation in CA1 subfield of hippocampal slices from aged senescence-accelerated mouse prone/8.
Topics: Age Factors; Aging; Analysis of Variance; Animals; D-Amino-Acid Oxidase; Drug Interactions; Electric | 2005 |
Altered dendritic integration in hippocampal granule cells of spatial learning-impaired aged rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Analysis of Variance; Animals; Behavior, Animal; Dendri | 2008 |
Synaptic commitment: developmentally regulated reciprocal changes in hippocampal granule cell NMDA and AMPA receptors over the lifespan.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Analysis of Variance; Animals; Behavior, Animal; Dose-R | 2008 |
MAP2 phosphorylation and visual plasticity in Xenopus.
Topics: Aging; Animals; Dendrites; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitator | 2001 |
Developmentally restricted synaptic plasticity in a songbird nucleus required for song learning.
Topics: Afferent Pathways; Aging; Animals; Axons; Electric Stimulation; Excitatory Amino Acid Antagonists; L | 2001 |