Compounds > 2-amino-5-phosphonovalerate
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2-amino-5-phosphonovalerate and Acute Edematous Pancreatitis

2-amino-5-phosphonovalerate has been researched along with Acute Edematous Pancreatitis in 2 studies

2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Research Excerpts

ExcerptRelevanceReference
" The current study examined spinal coadministration of low doses of NMDA receptor antagonist, D-(-)-2-Amino-5-phosphonovalerate (D-APV), and mu-opioid receptor agonist, morphine sulfate (MS), in reducing visceral nociception using an acute bradykinin induced pancreatitis model in rats."7.72Intrathecal coadministration of D-APV and morphine is maximally effective in a rat experimental pancreatitis model. ( Lu, Y; Vera-Portocarrero, LP; Westlund, KN, 2003)
" The current study examined spinal coadministration of low doses of NMDA receptor antagonist, D-(-)-2-Amino-5-phosphonovalerate (D-APV), and mu-opioid receptor agonist, morphine sulfate (MS), in reducing visceral nociception using an acute bradykinin induced pancreatitis model in rats."3.72Intrathecal coadministration of D-APV and morphine is maximally effective in a rat experimental pancreatitis model. ( Lu, Y; Vera-Portocarrero, LP; Westlund, KN, 2003)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lu, Y1
Vera-Portocarrero, LP1
Westlund, KN2
Zhang, L1
Zhang, X1

Other Studies

2 other studies available for 2-amino-5-phosphonovalerate and Acute Edematous Pancreatitis

ArticleYear
Intrathecal coadministration of D-APV and morphine is maximally effective in a rat experimental pancreatitis model.
    Anesthesiology, 2003, Volume: 98, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Animals; Bradykinin; Disease Models, Animal; Drug Therapy, Combination;

2003
Restoration of spontaneous exploratory behaviors with an intrathecal NMDA receptor antagonist or a PKC inhibitor in rats with acute pancreatitis.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 77, Issue:1

    Topics: Acute Disease; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors;

2004