2-amino-5-phosphonovalerate has been researched along with Acute Brain Injuries in 14 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 7.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 3.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 9 (64.29) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Palmer, CP | 1 |
| Metheny, HE | 1 |
| Elkind, JA | 1 |
| Cohen, AS | 1 |
| Seo, DO | 1 |
| Pang, MH | 1 |
| Shin, MS | 1 |
| Kim, HT | 1 |
| Choi, JS | 1 |
| Razak, KA | 1 |
| Huang, L | 1 |
| Pallas, SL | 1 |
| Petzold, GC | 1 |
| Windmüller, O | 1 |
| Haack, S | 1 |
| Major, S | 1 |
| Buchheim, K | 1 |
| Megow, D | 1 |
| Gabriel, S | 1 |
| Lehmann, TN | 1 |
| Drenckhahn, C | 1 |
| Peters, O | 1 |
| Meierkord, H | 1 |
| Heinemann, U | 1 |
| Dirnagl, U | 1 |
| Dreier, JP | 1 |
| Jin, X | 1 |
| Prince, DA | 1 |
| Huguenard, JR | 1 |
| Goforth, PB | 1 |
| Ellis, EF | 1 |
| Satin, LS | 1 |
| Santhakumar, V | 1 |
| Bender, R | 1 |
| Frotscher, M | 1 |
| Ross, ST | 2 |
| Hollrigel, GS | 1 |
| Toth, Z | 1 |
| Soltesz, I | 2 |
| Golarai, G | 1 |
| Greenwood, AC | 1 |
| Feeney, DM | 1 |
| Connor, JA | 1 |
| Zhang, X | 1 |
| Liu, E | 1 |
| Liu, X | 1 |
| Dai, Q | 1 |
| Nichols, J | 1 |
| Perez, R | 1 |
| Wu, C | 1 |
| Adelson, PD | 1 |
| Anderson, T | 1 |
| Duan, B | 1 |
| Wang, YZ | 1 |
| Yang, T | 1 |
| Chu, XP | 1 |
| Yu, Y | 1 |
| Huang, Y | 1 |
| Cao, H | 1 |
| Hansen, J | 1 |
| Simon, RP | 1 |
| Zhu, MX | 1 |
| Xiong, ZG | 1 |
| Xu, TL | 1 |
| Dzhala, V | 1 |
| Valeeva, G | 1 |
| Glykys, J | 1 |
| Khazipov, R | 1 |
| Staley, K | 1 |
| Suma, T | 1 |
| Koshinaga, M | 1 |
| Fukushima, M | 1 |
| Kano, T | 1 |
| Katayama, Y | 1 |
14 other studies available for 2-amino-5-phosphonovalerate and Acute Brain Injuries
| Article | Year |
|---|---|
Diminished amygdala activation and behavioral threat response following traumatic brain injury.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Brain Injuries | 2016 |
Hippocampal NMDA receptors are necessary for auditory trace fear conditioning measured with conditioned hypoalgesia in rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Association Learning; Behavior, Animal; | 2008 |
NMDA receptor blockade in the superior colliculus increases receptive field size without altering velocity and size tuning.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cricetinae; Electrophysiology; Excitatory Amin | 2003 |
Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Body Temperature; Brain; Brain Injuries; Cortical Spreading De | 2005 |
Enhanced excitatory synaptic connectivity in layer v pyramidal neurons of chronically injured epileptogenic neocortex in rats.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Br | 2006 |
Enhancement of AMPA-mediated current after traumatic injury in cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anim | 1999 |
Granule cell hyperexcitability in the early post-traumatic rat dentate gyrus: the 'irritable mossy cell' hypothesis.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuc | 2000 |
Selective depolarization of interneurons in the early posttraumatic dentate gyrus: involvement of the Na(+)/K(+)-ATPase.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Benzo | 2000 |
Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cell Count; Cell Death; Chronic Disease; Denta | 2001 |
Changes in and effective factors of microtubule-associated protein 2 in traumatic neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cold Temperature; Fluorescent Antibody Techniq | 2001 |
Traumatic brain injury induces rapid enhancement of cortical excitability in juvenile rats.
Topics: Animals; Animals, Newborn; Biophysics; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Elec | 2015 |
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
Topics: Acid Sensing Ion Channels; Acidosis; Amino Acid Transport System y+; Animals; Biophysics; Brain Inju | 2011 |
Traumatic alterations in GABA signaling disrupt hippocampal network activity in the developing brain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; Animals; Animals, Newborn; Ant | 2012 |
Effects of in situ administration of excitatory amino acid antagonists on rapid microglial and astroglial reactions in rat hippocampus following traumatic brain injury.
Topics: Animals; Astrocytes; Brain Injuries; CD11b Antigen; Disease Models, Animal; Excitatory Amino Acid An | 2008 |