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2-amino-5-phosphonovalerate and Acute Brain Injuries

2-amino-5-phosphonovalerate has been researched along with Acute Brain Injuries in 14 studies

2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Research Excerpts

ExcerptRelevanceReference
" Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis."7.77Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011)
" Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis."3.77Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's9 (64.29)29.6817
2010's4 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Palmer, CP1
Metheny, HE1
Elkind, JA1
Cohen, AS1
Seo, DO1
Pang, MH1
Shin, MS1
Kim, HT1
Choi, JS1
Razak, KA1
Huang, L1
Pallas, SL1
Petzold, GC1
Windmüller, O1
Haack, S1
Major, S1
Buchheim, K1
Megow, D1
Gabriel, S1
Lehmann, TN1
Drenckhahn, C1
Peters, O1
Meierkord, H1
Heinemann, U1
Dirnagl, U1
Dreier, JP1
Jin, X1
Prince, DA1
Huguenard, JR1
Goforth, PB1
Ellis, EF1
Satin, LS1
Santhakumar, V1
Bender, R1
Frotscher, M1
Ross, ST2
Hollrigel, GS1
Toth, Z1
Soltesz, I2
Golarai, G1
Greenwood, AC1
Feeney, DM1
Connor, JA1
Zhang, X1
Liu, E1
Liu, X1
Dai, Q1
Nichols, J1
Perez, R1
Wu, C1
Adelson, PD1
Anderson, T1
Duan, B1
Wang, YZ1
Yang, T1
Chu, XP1
Yu, Y1
Huang, Y1
Cao, H1
Hansen, J1
Simon, RP1
Zhu, MX1
Xiong, ZG1
Xu, TL1
Dzhala, V1
Valeeva, G1
Glykys, J1
Khazipov, R1
Staley, K1
Suma, T1
Koshinaga, M1
Fukushima, M1
Kano, T1
Katayama, Y1

Other Studies

14 other studies available for 2-amino-5-phosphonovalerate and Acute Brain Injuries

ArticleYear
Diminished amygdala activation and behavioral threat response following traumatic brain injury.
    Experimental neurology, 2016, Volume: 277

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Brain Injuries

2016
Hippocampal NMDA receptors are necessary for auditory trace fear conditioning measured with conditioned hypoalgesia in rats.
    Behavioural brain research, 2008, Oct-10, Volume: 192, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Association Learning; Behavior, Animal;

2008
NMDA receptor blockade in the superior colliculus increases receptive field size without altering velocity and size tuning.
    Journal of neurophysiology, 2003, Volume: 90, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cricetinae; Electrophysiology; Excitatory Amin

2003
Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.
    Stroke, 2005, Volume: 36, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; Animals; Body Temperature; Brain; Brain Injuries; Cortical Spreading De

2005
Enhanced excitatory synaptic connectivity in layer v pyramidal neurons of chronically injured epileptogenic neocortex in rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, May-03, Volume: 26, Issue:18

    Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Br

2006
Enhancement of AMPA-mediated current after traumatic injury in cortical neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Sep-01, Volume: 19, Issue:17

    Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anim

1999
Granule cell hyperexcitability in the early post-traumatic rat dentate gyrus: the 'irritable mossy cell' hypothesis.
    The Journal of physiology, 2000, Apr-01, Volume: 524 Pt 1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuc

2000
Selective depolarization of interneurons in the early posttraumatic dentate gyrus: involvement of the Na(+)/K(+)-ATPase.
    Journal of neurophysiology, 2000, Volume: 83, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Benzo

2000
Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Nov-01, Volume: 21, Issue:21

    Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cell Count; Cell Death; Chronic Disease; Denta

2001
Changes in and effective factors of microtubule-associated protein 2 in traumatic neurons.
    Chinese medical journal, 2001, Volume: 114, Issue:10

    Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cold Temperature; Fluorescent Antibody Techniq

2001
Traumatic brain injury induces rapid enhancement of cortical excitability in juvenile rats.
    CNS neuroscience & therapeutics, 2015, Volume: 21, Issue:2

    Topics: Animals; Animals, Newborn; Biophysics; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Elec

2015
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Feb-09, Volume: 31, Issue:6

    Topics: Acid Sensing Ion Channels; Acidosis; Amino Acid Transport System y+; Animals; Biophysics; Brain Inju

2011
Traumatic alterations in GABA signaling disrupt hippocampal network activity in the developing brain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Mar-21, Volume: 32, Issue:12

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; Animals; Animals, Newborn; Ant

2012
Effects of in situ administration of excitatory amino acid antagonists on rapid microglial and astroglial reactions in rat hippocampus following traumatic brain injury.
    Neurological research, 2008, Volume: 30, Issue:4

    Topics: Animals; Astrocytes; Brain Injuries; CD11b Antigen; Disease Models, Animal; Excitatory Amino Acid An

2008