2-amino-5-phosphonovalerate has been researched along with Acidosis in 4 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 7.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 3.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| "Acidosis accompanying cerebral ischemia activates acid-sensing ion channels (ASIC) causing increases in intracellular calcium concentration ([Ca(2+)]i) and enhanced neuronal death." | 1.36 | ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis. ( Cuevas, J; Katnik, C; Mari, Y, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mari, Y | 1 |
| Katnik, C | 1 |
| Cuevas, J | 1 |
| Wang, W | 1 |
| Richerson, GB | 1 |
| Duan, B | 1 |
| Wang, YZ | 1 |
| Yang, T | 1 |
| Chu, XP | 1 |
| Yu, Y | 1 |
| Huang, Y | 1 |
| Cao, H | 1 |
| Hansen, J | 1 |
| Simon, RP | 1 |
| Zhu, MX | 1 |
| Xiong, ZG | 1 |
| Xu, TL | 1 |
| Cronberg, T | 1 |
| Jensen, K | 1 |
| Rytter, A | 1 |
| Wieloch, T | 1 |
4 other studies available for 2-amino-5-phosphonovalerate and Acidosis
| Article | Year |
|---|---|
ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis.
Topics: 2-Amino-5-phosphonovalerate; Acid Sensing Ion Channels; Acidosis; Animals; Brain Ischemia; Calcium; | 2010 |
Chemosensitivity of non-respiratory rat CNS neurons in tissue culture.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acidosis; Action Potentials; Anim | 2000 |
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
Topics: Acid Sensing Ion Channels; Acidosis; Amino Acid Transport System y+; Animals; Biophysics; Brain Inju | 2011 |
Selective sparing of hippocampal CA3 cells following in vitro ischemia is due to selective inhibition by acidosis.
Topics: Acidosis; Animals; Animals, Newborn; Calcium; Cell Death; Excitatory Amino Acid Antagonists; Excitat | 2005 |