2-amino-5-phosphonovalerate has been researched along with Absence Status in 10 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using a lithium-pilocarpine model to induce status epilepticus (SE) in rats, the present study investigated whether the induction of LTP was altered in hippocampal slices obtained 3 h, 1, 3, and 7 days after SE." | 7.83 | Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model. ( Kim, KK; Kryukov, KA; Magazanik, LG; Zaitsev, AV, 2016) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 5.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| "The latency to first seizure, the number of seizure episodes and the duration of overt SE, as well as the incidence of deaths was scored with simultaneous electroencephalographic (EEG) recordings." | 5.40 | Orphenadrine-induced convulsive status epilepticus in rats responds to the NMDA antagonist dizocilpine. ( Czuczwar, M; Kiś, J; Nieoczym, D; Rejdak, K; Turski, WA; Wlaź, P, 2014) |
| " Using a lithium-pilocarpine model to induce status epilepticus (SE) in rats, the present study investigated whether the induction of LTP was altered in hippocampal slices obtained 3 h, 1, 3, and 7 days after SE." | 3.83 | Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model. ( Kim, KK; Kryukov, KA; Magazanik, LG; Zaitsev, AV, 2016) |
| "We studied the efficacy of the competitive NMDA receptor antagonist CGP 40116 in protecting against seizure-induced neuronal necrosis from lithium-pilocarpine-induced status epilepticus (SE)." | 3.69 | The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage. ( Daniels, AH; Fujikawa, DG; Kim, JS, 1994) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 1.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| "The latency to first seizure, the number of seizure episodes and the duration of overt SE, as well as the incidence of deaths was scored with simultaneous electroencephalographic (EEG) recordings." | 1.40 | Orphenadrine-induced convulsive status epilepticus in rats responds to the NMDA antagonist dizocilpine. ( Czuczwar, M; Kiś, J; Nieoczym, D; Rejdak, K; Turski, WA; Wlaź, P, 2014) |
| "Status epilepticus was induced by intravenous kainate (15 mg/kg) and neuronal death was assessed in hippocampal CA3 sector 72 h following status epilepticus." | 1.30 | Non-NMDA but not NMDA blockade at deep prepiriform cortex protects against hippocampal cell death in status epilepticus. ( Kawaguchi, K; Simon, RP, 1997) |
| "Prolonged seizures have long been known to be associated with cell injury and cell death in brain." | 1.29 | The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats. ( Graham, SH; Simon, RP; Tanaka, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ivanov, AD | 1 |
| Zaitsev, AV | 2 |
| Rejdak, K | 1 |
| Nieoczym, D | 1 |
| Czuczwar, M | 1 |
| Kiś, J | 1 |
| Wlaź, P | 1 |
| Turski, WA | 1 |
| Kryukov, KA | 1 |
| Kim, KK | 1 |
| Magazanik, LG | 1 |
| Barmashenko, G | 1 |
| Hefft, S | 1 |
| Aertsen, A | 1 |
| Kirschstein, T | 1 |
| Köhling, R | 1 |
| Tu, B | 1 |
| Timofeeva, O | 1 |
| Jiao, Y | 1 |
| Nadler, JV | 1 |
| Fujikawa, DG | 1 |
| Daniels, AH | 1 |
| Kim, JS | 1 |
| Tanaka, K | 1 |
| Graham, SH | 1 |
| Simon, RP | 2 |
| Kawaguchi, K | 1 |
| Fornai, F | 1 |
| Bassi, L | 1 |
| Gesi, M | 1 |
| Giorgi, FS | 1 |
| Guerrini, R | 1 |
| Bonaccorsi, I | 1 |
| Alessandrì, MG | 1 |
| González, MI | 1 |
| Grabenstatter, HL | 1 |
| Cea-Del Rio, CA | 1 |
| Cruz Del Angel, Y | 1 |
| Carlsen, J | 1 |
| Laoprasert, RP | 1 |
| White, AM | 1 |
| Huntsman, MM | 1 |
| Brooks-Kayal, A | 1 |
10 other studies available for 2-amino-5-phosphonovalerate and Absence Status
| Article | Year |
|---|---|
NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Mode | 2017 |
Orphenadrine-induced convulsive status epilepticus in rats responds to the NMDA antagonist dizocilpine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dizocilpine Maleate; Electroencephalography; | 2014 |
Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Hippocam | 2016 |
Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bi | 2011 |
Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Benzazepines; Bicuculline; Convulsants; Dentate Gyru | 2005 |
The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Diazepam; Electroenc | 1994 |
The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood Pressure; Cerebral Cortex; | 1996 |
Non-NMDA but not NMDA blockade at deep prepiriform cortex protects against hippocampal cell death in status epilepticus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Cell Death; Drug Evaluation, Preclinical; Exc | 1997 |
Similar increases in extracellular lactic acid in the limbic system during epileptic and/or olfactory stimulation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Convulsants; Denervation; Dose-Response Relationship, Drug; Ep | 2000 |
Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.
Topics: Animals; Biotinylation; Disease Models, Animal; Excitatory Amino Acid Antagonists; GABA Agonists; Ge | 2015 |