2-amino-5-phosphonovalerate has been researched along with Abdominal Epilepsy in 4 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "a model of partial epilepsy, competitive and uncompetitive NMDA antagonists exerted only weak anticonvulsant effects, whereas the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline (NBQX) potently increased focal seizure threshold and inhibited seizure spread from the focus." | 1.29 | Low doses of NMDA receptor antagonists synergistically increase the anticonvulsant effect of the AMPA receptor antagonist NBQX in the kindling model of epilepsy. ( Hönack, D; Löscher, W; Rundfeldt, C, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seiffert, E | 1 |
| Dreier, JP | 1 |
| Ivens, S | 1 |
| Bechmann, I | 1 |
| Tomkins, O | 1 |
| Heinemann, U | 1 |
| Friedman, A | 1 |
| Löscher, W | 1 |
| Rundfeldt, C | 1 |
| Hönack, D | 1 |
| Boda, B | 1 |
| Szente, M | 1 |
| de Curtis, M | 1 |
| Radici, C | 1 |
| Forti, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Blood- Brain Barrier Permeability in Neurological Patients: Anatomical, Neurophysiological, and Clinical Characteristics[NCT00419874] | 100 participants | Observational | Recruiting | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for 2-amino-5-phosphonovalerate and Abdominal Epilepsy
| Article | Year |
|---|---|
Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Bile Acids | 2004 |
Low doses of NMDA receptor antagonists synergistically increase the anticonvulsant effect of the AMPA receptor antagonist NBQX in the kindling model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Dizocilpine Maleate; Dose-Response | 1993 |
Nitric oxide synthase inhibitor facilitates focal seizures induced by aminopyridine in rat.
Topics: 2-Amino-5-phosphonovalerate; Aminopyridines; Animals; Arginine; Cerebral Ventricles; Drug Synergism; | 1996 |
Cellular mechanisms underlying spontaneous interictal spikes in an acute model of focal cortical epileptogenesis.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Acute Disease; | 1999 |