2-amino-5-phosphonovalerate has been researched along with AIDS Dementia Complex in 1 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
AIDS Dementia Complex: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, Tat, at similar concentrations, was toxic to human fetal neurons in culture." | 1.29 | Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. ( Brownstone, RM; Geiger, JD; Knudsen, BE; Magnuson, DS; Nath, A, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Magnuson, DS | 1 |
| Knudsen, BE | 1 |
| Geiger, JD | 1 |
| Brownstone, RM | 1 |
| Nath, A | 1 |
1 other study available for 2-amino-5-phosphonovalerate and AIDS Dementia Complex
| Article | Year |
|---|---|
Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.
Topics: 2-Amino-5-phosphonovalerate; AIDS Dementia Complex; Animals; Cells, Cultured; Cerebral Cortex; Dose- | 1995 |