2-amino-5-iodo-6-phenyl-4-pyrimidinone and Virus-Diseases

Interferon induction and antiviral activity was discovered with 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone. An analogue study incorporating a series of 2-amino-5-substituted-6-arylpyrimidinones revealed that the most potent interferon inducers were mono- and difluorophenyl analogues. These same analogues were also potent antiviral agents against Semliki Forest virus and herpes simplex type 1. In addition the monomethoxyphenyl analogues were potent antiviral agents but weak interferon inducers. Relatively modest structural changes led to dramatic changes in bioactivity. There was a relatively poor correlation between levels of circulating interferons induced and systemic antiviral activity.

Topics: Animals; Chemical Phenomena; Chemistry; Female; Halogens; Herpes Simplex; Interferon Inducers; Interferon Type I; Interferon-gamma; Male; Mice; Mice, Inbred ICR; Pyrimidinones; Semliki forest virus; Structure-Activity Relationship; Togaviridae Infections; Virus Diseases

Topics: Animals; Cytosine; Female; Immunity; Interferon Inducers; Interferons; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Pyrimidines; Pyrimidinones; Virus Diseases