2-amino-4-phosphonobutyric acid has been researched along with Seizures in 5 studies
2-amino-4-phosphonobutyric acid: glutamate antagonist in locust muscle; structure; do not confuse with L-AP4, which is the propionic acid version
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Convulsions were induced in rats by a single injection of pentylenetetrazol (PTZ) and [3H]L-2-amino-4-phosphonobutyrate ([3H]L-AP4) in vitro receptor autoradiography was used to evaluate the effects on the expression of group III metabotropic glutamate receptors." | 1.30 | Pentylenetetrazol-induced seizures increase [3H]L-2-amino-4-phosphonobutyrate binding in discrete regions of the rat brain. ( Thomsen, C, 1999) |
| "Blockade of these seizures with amino acid antagonists, phosphonocarboxylic acids, was achieved but with a reverse order of potency to that seen with the kindled amygdala." | 1.27 | Anticonvulsant action of amino acid antagonists against kindled hippocampal seizures. ( Bradford, HF; Collins, JF; Peterson, DW, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peterson, DW | 1 |
| Collins, JF | 2 |
| Bradford, HF | 2 |
| Coutinho-Netto, J | 1 |
| Abdul-Ghani, AS | 1 |
| Tizzano, JP | 1 |
| Griffey, KI | 1 |
| Schoepp, DD | 1 |
| Thomsen, C | 1 |
| Ryzhov, IV | 1 |
| Slepokurov, MV | 1 |
| Lapin, IP | 1 |
| Mandel'shtam, IuE | 1 |
| Aleksandrov, VG | 1 |
5 other studies available for 2-amino-4-phosphonobutyric acid and Seizures
| Article | Year |
|---|---|
Anticonvulsant action of amino acid antagonists against kindled hippocampal seizures.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminobutyrates; Animals; Anticonvulsants; Cerebral Ventric | 1984 |
Is glutamate a trigger factor in epileptic hyperactivity?
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cerebral Cortex; Electroencephalography; Epilep | 1981 |
Receptor subtypes linked to metabotropic glutamate receptor agonist-mediated limbic seizures in mice.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Cycloleucine; Dose-Response Relationship, Drug; | 1995 |
Pentylenetetrazol-induced seizures increase [3H]L-2-amino-4-phosphonobutyrate binding in discrete regions of the rat brain.
Topics: Aminobutyrates; Animals; Anticonvulsants; Autoradiography; Brain; Brain Chemistry; Convulsants; Fema | 1999 |
[Effect of excitant amino acid antagonists on glutamate receptors in the locust and on convulsions induced by glutamate, aspartate, kynurenine and quinolinic acid in mice].
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug | 1986 |