2-amino-4-phosphonobutyric acid has been researched along with Alzheimer Disease in 1 studies
2-amino-4-phosphonobutyric acid: glutamate antagonist in locust muscle; structure; do not confuse with L-AP4, which is the propionic acid version
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "L-Phosphoserine is a membrane metabolite that is elevated in Alzheimer's disease brain." | 2.38 | Possible roles of L-phosphoserine in the pathogenesis of Alzheimer's disease. ( Klunk, WE; McClure, RJ; Pettegrew, JW, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Klunk, WE | 1 |
| McClure, RJ | 1 |
| Pettegrew, JW | 1 |
1 review available for 2-amino-4-phosphonobutyric acid and Alzheimer Disease
| Article | Year |
|---|---|
Possible roles of L-phosphoserine in the pathogenesis of Alzheimer's disease.
Topics: Alzheimer Disease; Aminobutyrates; Animals; Humans; Phosphoserine; Receptors, N-Methyl-D-Aspartate | 1991 |