2-amino-4-hydroxy-6-formylpteridine has been researched along with Neoplasms* in 3 studies
1 review(s) available for 2-amino-4-hydroxy-6-formylpteridine and Neoplasms
| Article | Year |
|---|---|
Pterin-6-aldehyde production from folic acid by malignant tissues.
Topics: Erythrocytes; Folic Acid; Humans; Neoplasms; Pteridines; Pterins | 1977 |
2 other study(ies) available for 2-amino-4-hydroxy-6-formylpteridine and Neoplasms
| Article | Year |
|---|---|
Detection of pterin-6-aldehyde in urines of a healthy population.
Topics: Aldehydes; Humans; Neoplasms; Pteridines; Pterins | 1978 |
Pterin-6-aldehyde, a cancer cell catabolite: identification and application in diagnosis and treatment of human cancer.
Active folic acid degradation with the formation pterin-6-aldehyde is a previously undescribed characteristic of cancer cells in tissue culture. Neither normal adult epithelial and fibroblastic cells nor human amniotic cells nor mouse embryonic fibroblasts degrade folic acid to a measurable degree. Twenty-nine patients whose diagnoses were not revealed until after the test of their first morning urine for pterin-6-aldehyde was completed were studied for the presence or absence of pterin-6-aldehyde by thin-layer chromatography. Pterin-6-aldehyde was found in the urine at about 300 nmol/ml or greater only in those 13 patients with a tissue diagnosis of cancer. When the cancer was totally resected, the pterin-6-aldehyde was no longer found in the urine postoperatively. Pterin-6-aldehyde is not found in the urine of healthy patients at this level of detection unless their diets are supplemented with folic acid. Topics: Adolescent; Adult; Aged; Cell Line; Female; Folic Acid; Humans; Male; Middle Aged; Neoplasms; Pterins; Spectrometry, Fluorescence | 1977 |