Compounds > 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
Page last updated: 2024-08-24

2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and Precancerous Conditions

2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline has been researched along with Precancerous Conditions in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (33.33)18.2507
2000's8 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fukushima, S; Furukawa, F; Hirose, M; Imaida, K; Konishi, Y; Morimura, K; Nakae, D; Shirai, T; Tatematsu, M; Totsuka, Y; Tsuda, H; Tsukamoto, T; Uehara, N; Wakabayashi, K; Wanibuchi, H; Wei, M1
Fukushima, S; Furukawa, F; Hirose, M; Imaida, K; Konishi, Y; Morimura, K; Nakae, D; Shirai, T; Takasuka, N; Tatematsu, M; Tsuda, H; Tsukamoto, T; Wanibuchi, H; Wei, M1
Fukushima, S; Nakae, D; Nishkawa, T; Ogawa, M; Otani, S; Totsuka, Y; Wakabayashi, K; Wanibuchi, H; Yano, Y1
Fukushima, S; Ichihara, T; Morimura, K; Nakae, D; Totsuka, Y; Wanibuchi, H; Wei, M1
Fukushima, S; Hori, TA; Ichihara, T; Kang, JS; Morimura, K; Puatanachokchai, R; Wanibuchi, H; Wei, M1
Fukushima, S; Kang, JS; Mori, S; Morimura, K; Murai, T; Totsuka, Y; Wanibuchi, H1
Cui, L; Hasegawa, R; Hirose, M; Ito, N; Kato, T; Kobayashi, Y; Konishi, Y; Nakae, D; Shirai, T; Yaono, M1
Sugimura, T1
Fukushima, S1
Hirose, M; Kawabe, M; Kimoto, N; Lin, C; Sano, M; Shirai, T1
Furukawa, F; Mori, H; Mori, I; Nishikawa, A; Takahashi, M; Tanakamaru, Z1
Kushida, H; Nagao, M; Sone, H; Sugimura, T; Wakabayashi, K1

Other Studies

12 other study(ies) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and Precancerous Conditions

ArticleYear
Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine.
    Japanese journal of cancer research : Gann, 2002, Volume: 93, Issue:10

    Topics: Animals; Carcinogens; Diethylnitrosamine; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

2002
Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Cancer letters, 2003, Feb-28, Volume: 191, Issue:1

    Topics: Animals; Biomarkers; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Synergism; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

2003
Post-initiation inhibition of MeIQx hepatocarcinogenesis in rats by cysteine.
    Osaka city medical journal, 2003, Volume: 49, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cysteine; Deoxyguanosine; DNA; Genes, p53; Insulin-Like Growth Factor I; Liver Neoplasms, Experimental; Male; Nucleolus Organizer Region; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

2003
Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3,8-dimethylimidazo [4,5-f ]quinoxaline (MeIQx) in rats.
    Cancer science, 2004, Volume: 95, Issue:12

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Cell Proliferation; Colon; Colonic Neoplasms; Deoxyguanosine; Diet; DNA Adducts; Female; Glutathione Transferase; Humans; Lactation; Liver; Liver Neoplasms, Experimental; Male; Milk, Human; Placenta; Precancerous Conditions; Pregnancy; Quinoxalines; Rats; Rats, Inbred F344

2004
Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats.
    Cancer letters, 2006, Jan-18, Volume: 231, Issue:2

    Topics: Animals; Carcinogens; Glutathione S-Transferase pi; Liver; Liver Neoplasms, Experimental; Male; No-Observed-Adverse-Effect Level; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred BN; Rats, Inbred F344

2006
Evidence of a threshold-effect for 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline liver carcinogenicity in F344/DuCrj rats.
    Toxicologic pathology, 2008, Volume: 36, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma, Liver Cell; Administration, Oral; Animal Feed; Animals; Carcinogens; Carcinoma, Hepatocellular; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Liver; Liver Neoplasms; Longevity; Male; No-Observed-Adverse-Effect Level; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

2008
Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:2

    Topics: Animals; Body Weight; Carcinogens; Diet; Glutathione Transferase; Guanine; Liver; Liver Neoplasms; Male; Organ Size; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

1996
An overview of cancer prevention.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 1996, Volume: 5 Suppl 2

    Topics: beta Carotene; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Environmental Exposure; Humans; Imidazoles; Mutagens; Neoplasms; Neoplasms, Unknown Primary; Precancerous Conditions; Primary Prevention; Quinoxalines; Risk Factors

1996
Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Animals; Carcinogens; Diet; Food Contamination; Glutathione Transferase; Humans; Liver; Male; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

1999
Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation.
    Nutrition and cancer, 2000, Volume: 37, Issue:2

    Topics: Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Ethanol; Female; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Mammary Neoplasms, Experimental; Organ Size; Precancerous Conditions; Propolis; Quinoxalines; Random Allocation; Rats; Rats, Inbred F344; Water

2000
Essential similarities between spontaneous and MeIQx-promoted aberrant crypt foci in the F344 rat colon.
    Cancer letters, 2001, Oct-30, Volume: 172, Issue:2

    Topics: Animals; Carcinogens; Colonic Neoplasms; Genes, ras; Male; Mutagens; Mutation; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Quinoxalines; Rats; Rats, Inbred F344; Tumor Suppressor Protein p53

2001
Induction of preneoplastic lesions by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the livers of rats treated with carbon tetrachloride.
    Carcinogenesis, 1992, Volume: 13, Issue:5

    Topics: Animals; Carbon Tetrachloride; DNA; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

1992