Compounds > 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
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2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and Liver Neoplasms

2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline has been researched along with Liver Neoplasms in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's6 (42.86)18.2507
2000's7 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bendaly, J; Hein, DW; Metry, KJ; Neale, JR; Pierce, WM; Smith, NB1
Calvisi, DF; Conner, EA; Factor, VM; Ladu, S; Thorgeirsson, SS1
Chubachi, H; Imanishi, H; Inoue, Y; Komasa, Y; Mizoguchi, T; Nakano, M; Takekoshi, H1
Fukushima, S; Funae, Y; Kang, JS; Kinoshita, A; Kushida, M; Morimura, K; Puatanachokchai, R; Wanibuchi, H; Wei, M1
Fukushima, S; Hayashi, S; Kinoshita, A; Morimura, K; Nishikawa, T; Nishikawa-Ogawa, M; Wanibuchi, H; Yano, Y1
Ban, H; Hirata, A; Imai, T; Masegi, T; Nishigaki, R; Sakai, H; Takasu, S; Tatematsu, M; Totsuka, Y; Tsukamoto, T; Wakabayashi, K; Yanai, T1
Fukushima, S; Kang, JS; Mori, S; Morimura, K; Murai, T; Totsuka, Y; Wanibuchi, H1
Katami, M; Kurosaka, R; Kushida, H; Nagao, M; Sato, H; Wakabayashi, K1
Cui, L; Hasegawa, R; Hirose, M; Ito, N; Kato, T; Kobayashi, Y; Konishi, Y; Nakae, D; Shirai, T; Yaono, M1
Adamson, RH; Davis, CD; Schut, HA; Snyderwine, EG; Thorgeirsson, SS1
Adamson, RH; Dalgard, DW; Farb, A; Snyderwine, EG; Sugimura, T; Takayama, S; Thorgeirsson, SS; Thorgeirsson, UP; Virmani, R1
Darroudi, F; Knasmüller, S; Kundi, M; Land, SJ; Parzefall, W; Sanyal, R; Schwab, CE; Wang, CY1
Fukushima, S; Hakoi, K; Hasegawa, R; Ito, N; Iwasaki, S; Nagao, M; Shirai, T; Sugimura, T; Takaba, K; Wakabayashi, K1
Hasegawa, H; Kato, T; Ohgaki, H; Sato, S; Sugimura, T; Takayama, S1

Other Studies

14 other study(ies) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and Liver Neoplasms

ArticleYear
Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:11

    Topics: Acetylation; Animals; Animals, Congenic; Arylamine N-Acetyltransferase; Carcinogens; Colonic Neoplasms; Deoxyguanosine; DNA Adducts; Female; Gene Targeting; Genetic Predisposition to Disease; Imidazoles; Liver Neoplasms; Mutagens; Polymorphism, Genetic; Quinoxalines; Rats; Rats, Inbred F344; Rats, Inbred WKY; Time Factors

2009
Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice.
    Gastroenterology, 2004, Volume: 126, Issue:5

    Topics: alpha-Fetoproteins; Animals; beta Catenin; Cell Cycle Proteins; Cytoskeletal Proteins; Disease Models, Animal; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Gene Deletion; Gene Frequency; Genes, myc; Genomic Instability; Liver Neoplasms; Loss of Heterozygosity; Mice; Mice, Transgenic; Mutation; Phenotype; Quinoxalines; Trans-Activators; Transcription Factors; Transforming Growth Factor alpha

2004
Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa.
    Oncology reports, 2005, Volume: 14, Issue:2

    Topics: Animals; Body Weight; Chlorella; Diet; Diethylnitrosamine; Eating; Glutathione Transferase; Immunohistochemistry; Isoenzymes; Liver; Liver Neoplasms; Male; Organ Size; Quinoxalines; Rats; Rats, Inbred F344; Treatment Outcome

2005
Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: evidence for a threshold.
    Cancer science, 2005, Volume: 96, Issue:11

    Topics: Adenoma; Administration, Oral; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Cytochrome P-450 CYP2E1; DNA Damage; Dose-Response Relationship, Drug; Enzyme Induction; Ethanol; Liver Neoplasms; Male; Quinoxalines; Rats; Rats, Inbred F344; RNA, Messenger

2005
N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage.
    Carcinogenesis, 2006, Volume: 27, Issue:5

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Cysteine; Down-Regulation; Glutathione Transferase; Insulin-Like Growth Factor I; Liver Neoplasms; Nitric Oxide Synthase Type II; Placenta; Quinoxalines; Rats; Silver Staining; Time Factors

2006
Carcinogenic risk of heterocyclic amines in combination - assessment with a liver initiation model.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:6

    Topics: Amines; Animals; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA, Complementary; Glutathione Transferase; Hepatocytes; Heterocyclic Compounds; Imidazoles; Liver; Liver Neoplasms; Male; Oligonucleotide Array Sequence Analysis; Quinoxalines; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Risk

2008
Evidence of a threshold-effect for 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline liver carcinogenicity in F344/DuCrj rats.
    Toxicologic pathology, 2008, Volume: 36, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma, Liver Cell; Administration, Oral; Animal Feed; Animals; Carcinogens; Carcinoma, Hepatocellular; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Liver; Liver Neoplasms; Longevity; Male; No-Observed-Adverse-Effect Level; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

2008
Dose-response study of MeIQx carcinogenicity in F344 male rats.
    Cancer letters, 1994, Aug-15, Volume: 83, Issue:1-2

    Topics: Animals; Carcinogens; Female; Liver Neoplasms; Male; Neoplasms, Experimental; Quinoxalines; Rats; Rats, Inbred F344; Skin Neoplasms

1994
Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:2

    Topics: Animals; Body Weight; Carcinogens; Diet; Glutathione Transferase; Guanine; Liver; Liver Neoplasms; Male; Organ Size; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

1996
Possible relationship between tissue distribution of DNA adducts and genotoxicity of food-derived heterocyclic amines.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Amines; Animals; Carcinoma, Hepatocellular; Cattle; Cooking; DNA Adducts; Fishes; Heterocyclic Compounds; Hot Temperature; Humans; Liver Neoplasms; Macaca fascicularis; Meat; Mutagens; Poultry; Primates; Quinolines; Quinoxalines; Tissue Distribution

1995
Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Administration, Oral; Animals; Carcinogens; Cooking; DNA Adducts; Fibrosis; Heart; Hot Temperature; Humans; Imidazoles; Inflammation; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Macaca fascicularis; Meat; Myocardium; Necrosis; Quinolines; Quinoxalines

1995
Genotoxic effects of heterocyclic aromatic amines in human derived hepatoma (HepG2) cells.
    Mutagenesis, 1999, Volume: 14, Issue:6

    Topics: Amines; Animals; Arylamine N-Acetyltransferase; Carbolines; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Cell Survival; CHO Cells; Cricetinae; Heterocyclic Compounds; Humans; Imidazoles; Liver Neoplasms; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Salmonella; Tumor Cells, Cultured

1999
Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses.
    Carcinogenesis, 1991, Volume: 12, Issue:5

    Topics: Animals; Body Weight; Carbolines; Carcinogens; Drug Synergism; Enzyme Induction; Glutathione Transferase; Imidazoles; Immunohistochemistry; Liver; Liver Neoplasms; Male; Organ Size; Quinolines; Quinoxalines; Rats; Rats, Inbred F344

1991
Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Carcinogenesis, 1988, Volume: 9, Issue:1

    Topics: Animals; Clitoris; Female; Food; Genital Neoplasms, Female; Hot Temperature; Liver Neoplasms; Male; Neoplasms, Experimental; Quinoxalines; Rats; Rats, Inbred F344; Skin Neoplasms

1988