Compounds > 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
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2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and Experimental Hepatoma

2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline has been researched along with Experimental Hepatoma in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.45)18.7374
1990's11 (35.48)18.2507
2000's16 (51.61)29.6817
2010's2 (6.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Futakuchi, M; Hirose, M; Kawabe, M; Shirai, T; Tamano, S1
Asamoto, M; Doi, Y; Naiki-Ito, A; Shirai, T; Suzuki, S; Takahashi, S; Takeshita, K1
Hayashi, H; Hayashi, M; Mitsumori, K; Morita, R; Nakamura, D; Shibutani, M; Suzuki, K; Taniai, E; Wakita, A1
Asamoto, M; Hirose, M; Inaguma, S; Ogiso, T; Shirai, T; Suzuki, S; Takahashi, S1
Fukushima, S; Furukawa, F; Hirose, M; Imaida, K; Konishi, Y; Morimura, K; Nakae, D; Shirai, T; Tatematsu, M; Totsuka, Y; Tsuda, H; Tsukamoto, T; Uehara, N; Wakabayashi, K; Wanibuchi, H; Wei, M1
Furukawa, F; Hirose, M; Kobayashi, Y; Koide, A; Mori, Y; Nishikawa, A1
Fukushima, S; Furukawa, F; Hirose, M; Imaida, K; Konishi, Y; Morimura, K; Nakae, D; Shirai, T; Takasuka, N; Tatematsu, M; Tsuda, H; Tsukamoto, T; Wanibuchi, H; Wei, M1
Fukushima, S; Nakae, D; Nishkawa, T; Ogawa, M; Otani, S; Totsuka, Y; Wakabayashi, K; Wanibuchi, H; Yano, Y1
Fukushima, S; Ichihara, T; Morimura, K; Nakae, D; Totsuka, Y; Wanibuchi, H; Wei, M1
Fukushima, S; Hori, TA; Ichihara, T; Kang, JS; Morimura, K; Puatanachokchai, R; Wanibuchi, H; Wei, M1
Asamoto, M; Hokaiwado, N; Kuribayashi, M; Ogawa, K; Shirai, T; Suzuki, S1
Doi, K; Fukushima, S; Karim, MR; Kinoshita, A; Morimura, K; Wanibuchi, H; Wei, M1
Fukushima, S; Kang, JS; Morimura, K; Totsuka, Y; Wanibuchi, H; Yoshimura, I1
Fukushima, S; Kang, JS; Kinoshita, A; Morimura, K; Murai, T; Wanibuchi, H1
Blanck, A; Gustafsson, JA; Kleman, MI; Overvik, E; Porsch-Hällström, I1
Enomoto, K; Kushida, H; Mori, M; Nagao, M; Sone, H; Sugimura, T; Takeichi, N; Tsuda, H; Wakabayashi, K1
Adamson, RH; Dalgard, DW; Farb, A; Snyderwine, EG; Sugimura, T; Takayama, S; Thorgeirsson, SS; Thorgeirsson, UP; Virmani, R1
Adamson, RH; Dalgard, DW; Thorgeirsson, UP1
Inoue, R; Kakiuchi, H; Makino, H; Nagao, M; Sugimura, T; Ushijima, T1
Futakuchi, M; Hirose, M; Ito, T; Miki, T; Orita, SI; Shirai, T; Tanaka, H1
Degawa, M; Konno, Y; Moore, MA; Nakashita, K; Sekine, K; Takasuka, N; Tsuda, H; Uehara, N1
Futakuchi, M; Hirose, M; Ito, N; Lin, C; Shirai, T; Thamavit, W; Tiwawech, D1
Hirose, M; Kawabe, M; Kimoto, N; Lin, C; Sano, M; Shirai, T1
Furukawa, F; Hirose, M; Koide, A; Miyauchi, M; Mori, Y; Nishikawa, A; Okazaki, K; Son, HY1
Fukushima, S; Iwai, S; Karim, R; Kitano, M; Min, W; Morimura, K; Seki, S; Sukata, T; Wanibuchi, H1
Kushida, H; Nagao, M; Sone, H; Sugimura, T; Wakabayashi, K1
Bucci, T; Dooley, KL; Fu, PP; Kadlubar, FF; Von Tungeln, LS1
Adamson, RH; Schut, HA; Snyderwine, EG; Sugimura, T; Takayama, S; Thorgeirsson, SS; Thorgeirsson, UP; Turesky, RJ1
Ito, N; Ozaki, K; Takahashi, S; Tsuda, H; Yamaguchi, S1
Hasegawa, H; Ohgaki, H; Sato, S; Suenaga, M; Sugimura, T; Takayama, S1
Hasegawa, H; Kato, T; Ohgaki, H; Sato, S; Suenaga, M; Sugimura, T; Takayama, S1

Other Studies

31 other study(ies) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and Experimental Hepatoma

ArticleYear
Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesi
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:8

    Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Chitin; Chitosan; Colonic Neoplasms; Diethylnitrosamine; Female; Glutathione Peroxidase; Liver Neoplasms, Experimental; Male; Mammary Neoplasms, Animal; Organ Size; Quinoxalines; Rats; Rats, Inbred F344

2008
2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis is not enhanced by CYP1A inducers, alpha- and beta-naphthoflavone: relationship to intralobular distribution of CYP1A expression.
    Toxicologic pathology, 2010, Volume: 38, Issue:4

    Topics: Analysis of Variance; Animals; Arylamine N-Acetyltransferase; Benzoflavones; beta-Naphthoflavone; Body Weight; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochromes; Drug Synergism; Enzyme Inhibitors; Immunohistochemistry; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Organ Specificity; Quinoxalines; Rats; Rats, Inbred F344

2010
Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and β-naphthoflavone.
    The Journal of toxicological sciences, 2012, Volume: 37, Issue:5

    Topics: Animals; beta-Naphthoflavone; Carbon Tetrachloride; Carcinogens; Cyclooxygenase 2; Cytochrome P-450 CYP1A1; Diethylnitrosamine; Drug Synergism; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; Oligonucleotide Array Sequence Analysis; Omeprazole; Proton Pump Inhibitors; Quinoxalines; Rats; Rats, Inbred F344

2012
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole--a CYP1A2 inducer.
    Cancer letters, 2002, Nov-08, Volume: 185, Issue:1

    Topics: Animals; Antinematodal Agents; Arylamine N-Acetyltransferase; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A2; DNA Primers; Drug Combinations; Drug Synergism; Enzyme Induction; Fenbendazole; Glutathione Transferase; Immunoenzyme Techniques; Liver; Liver Neoplasms, Experimental; Male; Microsomes, Liver; Quinoxalines; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction

2002
Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine.
    Japanese journal of cancer research : Gann, 2002, Volume: 93, Issue:10

    Topics: Animals; Carcinogens; Diethylnitrosamine; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

2002
Effects of cigarette smoke and a heterocyclic amine, MeIQx on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver.
    Mutagenesis, 2003, Volume: 18, Issue:1

    Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Cocarcinogenesis; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Enzyme Induction; Glucuronosyltransferase; Imidazoles; Liver; Liver Neoplasms, Experimental; Male; Membrane Proteins; Microsomes, Liver; Quinoxalines; Rats; Rats, Inbred F344; Smoke; Specific Pathogen-Free Organisms; Steroid Hydroxylases; Substrate Specificity

2003
Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Cancer letters, 2003, Feb-28, Volume: 191, Issue:1

    Topics: Animals; Biomarkers; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Synergism; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

2003
Post-initiation inhibition of MeIQx hepatocarcinogenesis in rats by cysteine.
    Osaka city medical journal, 2003, Volume: 49, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cysteine; Deoxyguanosine; DNA; Genes, p53; Insulin-Like Growth Factor I; Liver Neoplasms, Experimental; Male; Nucleolus Organizer Region; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

2003
Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3,8-dimethylimidazo [4,5-f ]quinoxaline (MeIQx) in rats.
    Cancer science, 2004, Volume: 95, Issue:12

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Cell Proliferation; Colon; Colonic Neoplasms; Deoxyguanosine; Diet; DNA Adducts; Female; Glutathione Transferase; Humans; Lactation; Liver; Liver Neoplasms, Experimental; Male; Milk, Human; Placenta; Precancerous Conditions; Pregnancy; Quinoxalines; Rats; Rats, Inbred F344

2004
Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats.
    Cancer letters, 2006, Jan-18, Volume: 231, Issue:2

    Topics: Animals; Carcinogens; Glutathione S-Transferase pi; Liver; Liver Neoplasms, Experimental; Male; No-Observed-Adverse-Effect Level; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred BN; Rats, Inbred F344

2006
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences.
    Cancer letters, 2006, Feb-08, Volume: 232, Issue:2

    Topics: Acetyltransferases; Animals; Caffeine; Carcinogens; Cytochrome P-450 CYP1A2; Cytochromes; Enzyme Induction; Liver Neoplasms, Experimental; Male; Membrane Glycoproteins; Oligonucleotide Array Sequence Analysis; Proteoglycans; Quinoxalines; Rats; Rats, Inbred F344; Syndecan-2

2006
Existence of no hepatocarcinogenic effect levels of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline with or without coadministration with ethanol.
    Toxicologic pathology, 2006, Volume: 34, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinogens; Central Nervous System Depressants; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Ethanol; Glutathione S-Transferase pi; Immunohistochemistry; Liver; Liver Neoplasms, Experimental; Male; No-Observed-Adverse-Effect Level; Proliferating Cell Nuclear Antigen; Quinoxalines; Rats; Rats, Inbred F344

2006
Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide-induced liver damage in rats.
    Cancer science, 2006, Volume: 97, Issue:6

    Topics: 5-Methylcytosine; Animals; Carcinogens; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Immunohistochemistry; Liver Diseases; Liver Neoplasms, Experimental; Male; Quinoxalines; Rats; Thioacetamide

2006
Analysis of gene expression in different stages of MeIQx-induced rat hepatocarcinogenesis.
    Oncology reports, 2007, Volume: 17, Issue:4

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Gene Expression; Gene Expression Profiling; Liver; Liver Neoplasms, Experimental; Oligonucleotide Array Sequence Analysis; Quinoxalines; Rats; Rats, Inbred F344

2007
The heterocyclic amines IQ and MeIQx show no promotive effect in a short-term in vivo liver carcinogenesis assay.
    Carcinogenesis, 1993, Volume: 14, Issue:10

    Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Liver Neoplasms, Experimental; Male; Quinolines; Quinoxalines; Rats; Rats, Wistar

1993
Hepatocellular carcinoma induction in LEC rats by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:1

    Topics: Alanine Transaminase; Animals; Body Weight; Carcinogens; Copper; Dose-Response Relationship, Drug; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Quinoxalines; Rats; Rats, Inbred Strains

1996
Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Administration, Oral; Animals; Carcinogens; Cooking; DNA Adducts; Fibrosis; Heart; Hot Temperature; Humans; Imidazoles; Inflammation; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Macaca fascicularis; Meat; Myocardium; Necrosis; Quinolines; Quinoxalines

1995
Laparoscopy as a means of monitoring liver tumor induction in nonhuman primates.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Animals; Carcinogens; Equipment Design; Imidazoles; Laparoscopes; Laparoscopy; Liver Neoplasms, Experimental; Macaca mulatta; Palpation; Quinolines; Quinoxalines; Reproducibility of Results; Time Factors

1995
Genetic alterations in HCA-induced tumors.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Animals; Carcinogens; Colonic Neoplasms; Diet; Female; Food; Genes, p53; Genes, ras; Humans; Imidazoles; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Mutagenesis; Mutagens; Neoplasms, Experimental; Point Mutation; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Stomach Neoplasms

1995
Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: results of extended and combination treatment experiments.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 1998, Volume: 7, Issue:1

    Topics: Amines; Animals; Anticarcinogenic Agents; Antioxidants; Biological Assay; Carcinogens; Hydroquinones; Imidazoles; Liver Neoplasms, Experimental; Male; Mutagens; Quinoxalines; Rats; Rats, Inbred F344

1998
Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Animals; Caffeine; Carcinogens; Colonic Neoplasms; Drug Synergism; Imidazoles; Liver Neoplasms, Experimental; Male; Phosphodiesterase Inhibitors; Quinolines; Quinoxalines; Rats; Rats, Inbred F344

1999
Enhancing effects of Thai edible plants on 2-amino-3, 8-dimethylimidazo(4,5-f)quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay.
    Cancer letters, 2000, Oct-01, Volume: 158, Issue:2

    Topics: Animals; Carcinogenicity Tests; Carcinogens; Diet; Diethylnitrosamine; Drug Synergism; Glutathione Transferase; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Plants, Medicinal; Quinoxalines; Rats; Rats, Inbred F344; Thailand

2000
Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation.
    Nutrition and cancer, 2000, Volume: 37, Issue:2

    Topics: Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Ethanol; Female; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Mammary Neoplasms, Experimental; Organ Size; Precancerous Conditions; Propolis; Quinoxalines; Random Allocation; Rats; Rats, Inbred F344; Water

2000
Enhancement by cigarette smoke exposure of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis in close association with elevation of hepatic CYP1A2.
    Japanese journal of cancer research : Gann, 2002, Volume: 93, Issue:1

    Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Colon; Colonic Neoplasms; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Immunoblotting; Liver; Liver Neoplasms, Experimental; Male; Mutagens; Organ Size; Quinoxalines; Rats; Rats, Inbred F344; Smoking

2002
Role of oxidative DNA damage caused by carbon tetrachloride-induced liver injury -- enhancement of MeIQ-induced glutathione S-transferase placental form-positive foci in rats.
    Cancer letters, 2002, May-08, Volume: 179, Issue:1

    Topics: Animals; Bromodeoxyuridine; Carbon Tetrachloride; Carcinogens; DNA; DNA Damage; DNA Primers; DNA-Formamidopyrimidine Glycosylase; Glutathione Transferase; Guanosine; Immunoenzyme Techniques; Liver; Liver Neoplasms, Experimental; Male; N-Glycosyl Hydrolases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Placenta; Quinoxalines; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Transaminases

2002
Induction of preneoplastic lesions by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the livers of rats treated with carbon tetrachloride.
    Carcinogenesis, 1992, Volume: 13, Issue:5

    Topics: Animals; Carbon Tetrachloride; DNA; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

1992
Comparative carcinogenicity of 4-aminobiphenyl and the food pyrolysates, Glu-P-1, IQ, PhIP, and MeIQx in the neonatal B6C3F1 male mouse.
    Cancer letters, 1992, Mar-15, Volume: 62, Issue:3

    Topics: Aminobiphenyl Compounds; Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Imidazoles; Liver Neoplasms, Experimental; Male; Mice; Mutagens; Quinolines; Quinoxalines

1992
Metabolic processing and carcinogenicity of heterocyclic amines in nonhuman primates.
    Princess Takamatsu symposia, 1990, Volume: 21

    Topics: Animals; Chromatography, High Pressure Liquid; DNA; DNA Damage; Dose-Response Relationship, Immunologic; Imidazoles; Liver Neoplasms, Experimental; Macaca fascicularis; Mutagens; Quinolines; Quinoxalines

1990
Comparison of initiation potential of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in an in vivo carcinogen bioassay system.
    Carcinogenesis, 1990, Volume: 11, Issue:4

    Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Enzyme Induction; Galactosamine; Glutathione Transferase; Hepatectomy; Liver Neoplasms, Experimental; Male; Mutagens; Organ Size; Phenobarbital; Quinolines; Quinoxalines; Rats; Rats, Inbred F344

1990
Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods.
    Carcinogenesis, 1987, Volume: 8, Issue:5

    Topics: Animals; Cooking; Female; Food Analysis; Leukemia, Experimental; Liver Neoplasms, Experimental; Lung Neoplasms; Lymphoma; Male; Mice; Mutagens; Neoplasms, Experimental; Quinoxalines

1987
Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx.
    Princess Takamatsu symposia, 1985, Volume: 16

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma; Carcinoma, Squamous Cell; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Stomach Neoplasms

1985