Compounds > 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
Page last updated: 2024-08-24

2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and Cancer of Colon

2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline has been researched along with Cancer of Colon in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (16.67)18.2507
2000's7 (58.33)29.6817
2010's3 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cross, AJ; Harper, G; Hartman, TJ; Laio, J; Lazarus, P; Lesko, SM; Miller, PE; Muscat, JE; Sinha, R; Zhu, J1
Helmus, DS; Li, L; Thompson, CL; Tucker, TC; Zelenskiy, S1
Futakuchi, M; Hirose, M; Kawabe, M; Shirai, T; Tamano, S1
Bendaly, J; Hein, DW; Metry, KJ; Neale, JR; Pierce, WM; Smith, NB1
Inoue, T; Ishii, Y; Kodama, Y; Mitsumori, K; Nishikawa, A; Nohmi, T; Okamura, T; Suzuki, Y; Tasaki, M; Umemura, T1
Kohno, H; Sugie, S; Suzuki, R; Takahashi, M; Tanaka, T; Wakabayashi, K1
Fukushima, S; Ichihara, T; Morimura, K; Nakae, D; Totsuka, Y; Wanibuchi, H; Wei, M1
Hirose, M; Imazawa, T; Ishii, Y; Kanki, K; Kitamura, Y; Kuroiwa, Y; Nishikawa, A; Umemura, T1
Inoue, R; Kakiuchi, H; Makino, H; Nagao, M; Sugimura, T; Ushijima, T1
Degawa, M; Konno, Y; Moore, MA; Nakashita, K; Sekine, K; Takasuka, N; Tsuda, H; Uehara, N1
Furukawa, F; Mori, H; Mori, I; Nishikawa, A; Takahashi, M; Tanakamaru, Z1
Furukawa, F; Hirose, M; Koide, A; Miyauchi, M; Mori, Y; Nishikawa, A; Okazaki, K; Son, HY1

Other Studies

12 other study(ies) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and Cancer of Colon

ArticleYear
Meat-related compounds and colorectal cancer risk by anatomical subsite.
    Nutrition and cancer, 2013, Volume: 65, Issue:2

    Topics: Aged; Animals; Benzo(a)pyrene; Case-Control Studies; Colonic Neoplasms; Colorectal Neoplasms; Cooking; Feeding Behavior; Female; Humans; Imidazoles; Logistic Models; Male; Meat; Meat Products; Middle Aged; Nitrates; Nitrites; Pennsylvania; Poultry; Quinoxalines; Rectal Neoplasms; Risk Factors; Surveys and Questionnaires

2013
Red meat-derived heterocyclic amines increase risk of colon cancer: a population-based case-control study.
    Nutrition and cancer, 2013, Volume: 65, Issue:8

    Topics: Aged; Amines; Case-Control Studies; Colonic Neoplasms; Confidence Intervals; Cooking; Female; Humans; Logistic Models; Male; Meat; Middle Aged; Mutagens; Nutrition Assessment; Odds Ratio; Polycyclic Aromatic Hydrocarbons; Quinoxalines; Risk Factors; Surveys and Questionnaires

2013
Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesi
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:8

    Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Chitin; Chitosan; Colonic Neoplasms; Diethylnitrosamine; Female; Glutathione Peroxidase; Liver Neoplasms, Experimental; Male; Mammary Neoplasms, Animal; Organ Size; Quinoxalines; Rats; Rats, Inbred F344

2008
Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:11

    Topics: Acetylation; Animals; Animals, Congenic; Arylamine N-Acetyltransferase; Carcinogens; Colonic Neoplasms; Deoxyguanosine; DNA Adducts; Female; Gene Targeting; Genetic Predisposition to Disease; Imidazoles; Liver Neoplasms; Mutagens; Polymorphism, Genetic; Quinoxalines; Rats; Rats, Inbred F344; Rats, Inbred WKY; Time Factors

2009
Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice.
    The Journal of toxicological sciences, 2010, Volume: 35, Issue:5

    Topics: Animals; Cocarcinogenesis; Colonic Neoplasms; Dextran Sulfate; Escherichia coli Proteins; Male; Mice; Mice, Transgenic; Mutagens; Pentosyltransferases; Quinoxalines; Tumor Suppressor Protein p53

2010
Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cycloox
    Carcinogenesis, 2005, Volume: 26, Issue:1

    Topics: Adenocarcinoma; Animals; Anticoagulants; Base Sequence; beta Catenin; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Cytoskeletal Proteins; Dextran Sulfate; Disease Models, Animal; Imidazoles; Immunohistochemistry; Male; Mice; Mice, Inbred ICR; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Restriction Mapping; Trans-Activators

2005
Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3,8-dimethylimidazo [4,5-f ]quinoxaline (MeIQx) in rats.
    Cancer science, 2004, Volume: 95, Issue:12

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Cell Proliferation; Colon; Colonic Neoplasms; Deoxyguanosine; Diet; DNA Adducts; Female; Glutathione Transferase; Humans; Lactation; Liver; Liver Neoplasms, Experimental; Male; Milk, Human; Placenta; Precancerous Conditions; Pregnancy; Quinoxalines; Rats; Rats, Inbred F344

2004
Induction of colon tumors in C57BL/6J mice fed MeIQx, IQ, or PhIP followed by dextran sulfate sodium treatment.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 84, Issue:2

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Diet; Drug Therapy, Combination; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Quinolines; Quinoxalines

2005
Genetic alterations in HCA-induced tumors.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Animals; Carcinogens; Colonic Neoplasms; Diet; Female; Food; Genes, p53; Genes, ras; Humans; Imidazoles; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Mutagenesis; Mutagens; Neoplasms, Experimental; Point Mutation; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Stomach Neoplasms

1995
Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Animals; Caffeine; Carcinogens; Colonic Neoplasms; Drug Synergism; Imidazoles; Liver Neoplasms, Experimental; Male; Phosphodiesterase Inhibitors; Quinolines; Quinoxalines; Rats; Rats, Inbred F344

1999
Essential similarities between spontaneous and MeIQx-promoted aberrant crypt foci in the F344 rat colon.
    Cancer letters, 2001, Oct-30, Volume: 172, Issue:2

    Topics: Animals; Carcinogens; Colonic Neoplasms; Genes, ras; Male; Mutagens; Mutation; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Quinoxalines; Rats; Rats, Inbred F344; Tumor Suppressor Protein p53

2001
Enhancement by cigarette smoke exposure of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis in close association with elevation of hepatic CYP1A2.
    Japanese journal of cancer research : Gann, 2002, Volume: 93, Issue:1

    Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Colon; Colonic Neoplasms; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Immunoblotting; Liver; Liver Neoplasms, Experimental; Male; Mutagens; Organ Size; Quinoxalines; Rats; Rats, Inbred F344; Smoking

2002