2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Sensitivity and Specificity in 15 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The results indicate that unconjugated N-OH-PhIP is not excreted in the urine after oral dosing with PhIP and that the two isomeric N-glucuronides of N-OH-PhIP, which are formed as major metabolites, are stable under acidic conditions." | 1.29 | Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis. ( Bartsch, H; Butler, MA; Friesen, MD; Ilett, KF; Kaderlik, RK; Kadlubar, F; Lin, D; Minchin, RF; Mulder, GJ; Teitel, CH, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 9 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nettles, KW | 1 |
| Bruning, JB | 1 |
| Gil, G | 1 |
| Nowak, J | 1 |
| Sharma, SK | 1 |
| Hahm, JB | 1 |
| Kulp, K | 1 |
| Hochberg, RB | 1 |
| Zhou, H | 1 |
| Katzenellenbogen, JA | 1 |
| Katzenellenbogen, BS | 1 |
| Kim, Y | 1 |
| Joachmiak, A | 1 |
| Greene, GL | 1 |
| Grant, PG | 1 |
| Palmblad, M | 1 |
| Murov, S | 1 |
| Hillegonds, DJ | 1 |
| Ueda, DL | 1 |
| Vogel, JS | 1 |
| Bench, G | 1 |
| Fang, M | 1 |
| Edwards, RJ | 1 |
| Bartlet-Jones, M | 1 |
| Taylor, GW | 1 |
| Murray, S | 1 |
| Boobis, AR | 1 |
| Bianchi, F | 1 |
| Careri, M | 1 |
| Corradini, C | 1 |
| Elviri, L | 1 |
| Mangia, A | 1 |
| Zagnoni, I | 1 |
| Scott, KA | 1 |
| Turesky, RJ | 2 |
| Wainman, BC | 1 |
| Josephy, PD | 1 |
| Goodenough, AK | 1 |
| Schut, HA | 1 |
| Morgenthaler, PM | 1 |
| Holzhäuser, D | 1 |
| Kadlubar, F | 1 |
| Kaderlik, RK | 1 |
| Mulder, GJ | 1 |
| Lin, D | 1 |
| Butler, MA | 1 |
| Teitel, CH | 1 |
| Minchin, RF | 1 |
| Ilett, KF | 1 |
| Friesen, MD | 1 |
| Bartsch, H | 1 |
| Mauthe, RJ | 1 |
| Marsch, GA | 1 |
| Turteltaub, KW | 3 |
| Imaida, K | 1 |
| Hagiwara, A | 1 |
| Yada, H | 1 |
| Masui, T | 1 |
| Hasegawa, R | 1 |
| Hirose, M | 1 |
| Sugimura, T | 1 |
| Ito, N | 1 |
| Shirai, T | 1 |
| Dingley, KH | 2 |
| Roberts, ML | 1 |
| Velsko, CA | 1 |
| Magagnotti, C | 1 |
| Orsi, F | 1 |
| Bagnati, R | 1 |
| Celli, N | 1 |
| Rotilio, D | 1 |
| Fanelli, R | 1 |
| Airoldi, L | 1 |
| Burnouf, D | 1 |
| Miturski, R | 1 |
| Nagao, M | 1 |
| Nakagama, H | 1 |
| Nothisen, M | 1 |
| Wagner, J | 1 |
| Fuchs, RP | 1 |
| Knize, MG | 1 |
| Kulp, KS | 1 |
| Malfatti, MA | 1 |
| Salmon, CP | 1 |
| Felton, JS | 1 |
15 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Sensitivity and Specificity
| Article | Year |
|---|---|
NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.
Topics: Binding Sites; Bridged Bicyclo Compounds; Crystallography, X-Ray; Humans; Hydrogen Bonding; Ligands; | 2008 |
Alpha-particle energy loss measurement of microgram depositions of biomolecules.
Topics: Alpha Particles; Animals; Cattle; Imidazoles; Male; Rats; Rats, Sprague-Dawley; Reproducibility of R | 2003 |
Urinary N2-(2'-deoxyguanosin-8-yl)PhIP as a biomarker for PhIP exposure.
Topics: Animals; Biomarkers; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; Imidazoles; | 2004 |
Investigation of the separation of heterocyclic aromatic amines by reversed phase ion-pair liquid chromatography coupled with tandem mass spectrometry: the role of ion pair reagents on LC-MS/MS sensitivity.
Topics: Acetonitriles; Amines; Buffers; Carbolines; Chromatography, Liquid; Formates; Harmine; Heterocyclic | 2005 |
Hplc/electrospray ionization mass spectrometric analysis of the heterocyclic aromatic amine carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in human milk.
Topics: Carcinogens; Chromatography, High Pressure Liquid; Humans; Imidazoles; Milk, Human; Poultry Products | 2007 |
Novel LC-ESI/MS/MS(n) method for the characterization and quantification of 2'-deoxyguanosine adducts of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by 2-D linear quadrupole ion trap mass spectrometry.
Topics: Animals; Carcinogens; Chromatography, Liquid; Colon; Deoxyguanosine; Diet; DNA Adducts; Female; Imid | 2007 |
Analysis of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human lymphoblastoid cells.
Topics: Base Sequence; Cell Survival; Cells, Cultured; DNA Mutational Analysis; Humans; Imidazoles; Lymphocy | 1995 |
Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis.
Topics: Animals; Arylamine N-Acetyltransferase; Biotransformation; Carcinogens; Colonic Neoplasms; Cytochrom | 1995 |
Improved high-performance liquid chromatography analysis of 32P-postlabeled 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adducts using in-line precolumn purification.
Topics: Animals; Carcinogens; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA; | 1996 |
Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine.
Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Cell Division; Dose-Response Relationship, Drug; | 1996 |
Attomole detection of 3H in biological samples using accelerator mass spectrometry: application in low-dose, dual-isotope tracer studies in conjunction with 14C accelerator mass spectrometry.
Topics: Animals; Carbon Radioisotopes; DNA Adducts; Imidazoles; Male; Mass Spectrometry; Quinolines; Radiati | 1998 |
Application of accelerated mass spectrometry (AMS) in DNA adduct quantification and identification.
Topics: DNA Adducts; Imidazoles; Mass Spectrometry; Quinoxalines; Sensitivity and Specificity | 1998 |
Effect of diet on serum albumin and hemoglobin adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans.
Topics: Animals; Biomarkers; Carcinogens; Chromatography, Liquid; Diet; Diet, Vegetarian; Gas Chromatography | 2000 |
Early detection of 2-amino-1-methyl-6-phenylimidazo (4,5-b)pyridine(PhIP)-induced mutations within the Apc gene of rat colon.
Topics: Animals; Base Pair Mismatch; Carcinogens; Colonic Neoplasms; DNA Primers; DNA, Neoplasm; Electrophor | 2001 |
Liquid chromatography-tandem mass spectrometry method of urine analysis for determining human variation in carcinogen metabolism.
Topics: Adult; Carcinogens; Chromatography, High Pressure Liquid; Female; Humans; Imidazoles; Male; Mass Spe | 2001 |