Compounds > 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
Page last updated: 2024-10-21

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Prostatic Intraepithelial Neoplasia

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Prostatic Intraepithelial Neoplasia in 5 studies

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.

Prostatic Intraepithelial Neoplasia: A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.

Research Excerpts

ExcerptRelevanceReference
"To develop a relevant mouse model for prostate cancer prevention research, we administered a dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), to CYP1A-humanized mice."1.38Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice. ( Bosland, MC; Cheung, C; Li, G; Liu, AB; Reuhl, KR; Wang, H; Yang, CS, 2012)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, JX1
Li, G2
Wang, H2
Liu, A1
Lee, MJ1
Reuhl, K1
Suh, N1
Bosland, MC2
Yang, CS2
Liu, AB1
Cheung, C1
Reuhl, KR1
Cho, YM2
Takahashi, S2
Asamoto, M1
Suzuki, S2
Inaguma, S2
Hokaiwado, N1
Shirai, T2
Ohnishi, H1
Borowsky, AD1
Dingley, KH1
Ubick, E1
Turteltaub, KW1
Cardiff, RD1
Devere-White, R1

Other Studies

5 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Prostatic Intraepithelial Neoplasia

ArticleYear
Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice.
    Cancer letters, 2016, Feb-01, Volume: 371, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Cyclooxygenase 2; Cytochrome P-450 CY

2016
Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.
    Cancer prevention research (Philadelphia, Pa.), 2012, Volume: 5, Issue:7

    Topics: Animals; Cadherins; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 CYP1A2; Diet, Hig

2012
Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: lack of influence of carcinogen or testosterone treatment.
    Cancer science, 2003, Volume: 94, Issue:2

    Topics: Adenocarcinoma; Age Factors; Aminobiphenyl Compounds; Androgen Antagonists; Androgen-Binding Protein

2003
High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) prostate carcinogenesis.
    Cancer science, 2003, Volume: 94, Issue:11

    Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Disease Progression; Disease S

2003
Inflammation and atrophy precede prostatic neoplasia in a PhIP-induced rat model.
    Neoplasia (New York, N.Y.), 2006, Volume: 8, Issue:9

    Topics: Animals; Atrophy; Carcinogens; Cell Proliferation; Disease Models, Animal; Glutathione Transferase;

2006