2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Prostatic Hyperplasia in 2 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Prostatic Hyperplasia: Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, benign prostatic hyperplasia tissues, obtained by transurethral resection or radical retropubic prostatectomy from UK-resident individuals (n = 18), were examined for CYP1 expression and for their ability, in short-term organ culture, to metabolically activate carcinogens found in cooked meat." | 1.31 | Metabolic activation of carcinogens and expression of various cytochromes P450 in human prostate tissue. ( Grover, PL; Hewer, A; Martin, FL; Muir, GH; Phillips, DH; Williams, JA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shirai, T | 1 |
| Sano, M | 1 |
| Tamano, S | 1 |
| Takahashi, S | 1 |
| Hirose, M | 1 |
| Futakuchi, M | 1 |
| Hasegawa, R | 1 |
| Imaida, K | 1 |
| Matsumoto, K | 1 |
| Wakabayashi, K | 1 |
| Sugimura, T | 1 |
| Ito, N | 1 |
| Williams, JA | 1 |
| Martin, FL | 1 |
| Muir, GH | 1 |
| Hewer, A | 1 |
| Grover, PL | 1 |
| Phillips, DH | 1 |
2 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Prostatic Hyperplasia
| Article | Year |
|---|---|
The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.
Topics: Animals; Carcinogens; Imidazoles; Male; Neoplasms, Experimental; Prostate; Prostatic Hyperplasia; Pr | 1997 |
Metabolic activation of carcinogens and expression of various cytochromes P450 in human prostate tissue.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biotransformation; Carcinogens; Cytochrome P-4 | 2000 |