2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Pregnancy in 10 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sulforaphane (SFN) is a derivative of a glucosinolate, which is abundant in cruciferous vegetables, and can pass through the placental barrier." | 1.62 | Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development. ( Bao, Y; Brand-Saberi, B; Cheng, X; Li, T; Liu, C; Liu, X; Qi, S; Sindi, M; Wang, G; Yan, Y; Yang, W; Yang, X; Zhang, P, 2021) |
| "We tested in human breast cancer adenocarcinoma cell line MCF-7 whether ethanol affects ABCG2/BCRP, which is also the major transporter in human placenta." | 1.37 | Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion. ( Auriola, S; Halonen, T; Karttunen, V; Myllynen, P; Myöhänen, K; Vähäkangas, K; Veid, J, 2011) |
| " HPLC analysis of stomach contents and tissues of newborn mice exposed for 4 hr to lactating dams dosed ip with [3H]PhIP (5." | 1.29 | Transfer of the food mutagen PhIP to foetuses and newborn mice following maternal exposure. ( Brittebo, EB; Jägerstad, IM; Karlsson, AA; Skog, KI, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, P | 1 |
| Li, T | 1 |
| Liu, C | 1 |
| Sindi, M | 1 |
| Cheng, X | 1 |
| Qi, S | 1 |
| Liu, X | 1 |
| Yan, Y | 1 |
| Bao, Y | 1 |
| Brand-Saberi, B | 1 |
| Yang, W | 1 |
| Wang, G | 1 |
| Yang, X | 1 |
| Myllynen, P | 4 |
| Kummu, M | 3 |
| Kangas, T | 1 |
| Ilves, M | 1 |
| Immonen, E | 1 |
| Rysä, J | 1 |
| Pirilä, R | 1 |
| Lastumäki, A | 1 |
| Vähäkangas, KH | 1 |
| Veid, J | 1 |
| Karttunen, V | 2 |
| Myöhänen, K | 2 |
| Auriola, S | 1 |
| Halonen, T | 1 |
| Vähäkangas, K | 3 |
| Mose, T | 1 |
| Mathiesen, L | 1 |
| Nielsen, JK | 1 |
| Sieppi, E | 2 |
| Mørck, TA | 1 |
| Partanen, H | 1 |
| Knudsen, LE | 1 |
| Wallin, K | 1 |
| Rautio, A | 1 |
| Shan, L | 1 |
| He, M | 1 |
| Yu, M | 1 |
| Qiu, C | 1 |
| Lee, NH | 1 |
| Liu, ET | 1 |
| Snyderwine, EG | 1 |
| Ikeda, Y | 1 |
| Cho, YM | 1 |
| Takahashi, S | 2 |
| Tang, M | 1 |
| Asamoto, M | 1 |
| Ogawa, K | 1 |
| Shirai, T | 2 |
| Hasegawa, R | 2 |
| Kimura, J | 2 |
| Yaono, M | 2 |
| Kato, T | 2 |
| Futakuchi, M | 1 |
| Fukutake, M | 1 |
| Fukutome, K | 1 |
| Wakabayashi, K | 2 |
| Sugimura, T | 2 |
| Brittebo, EB | 1 |
| Karlsson, AA | 1 |
| Skog, KI | 1 |
| Jägerstad, IM | 1 |
| Ito, N | 1 |
1 review available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Pregnancy
| Article | Year |
|---|---|
Meta-analysis of data from human ex vivo placental perfusion studies on genotoxic and immunotoxic agents within the integrated European project NewGeneris.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Area Under Curve; Central Nervous System Depres | 2012 |
9 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Pregnancy
| Article | Year |
|---|---|
Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development.
Topics: Animals; Carcinogens; Chick Embryo; Female; Imidazoles; Isothiocyanates; Placenta; Pregnancy; Sulfox | 2021 |
ABCG2/BCRP decreases the transfer of a food-born chemical carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in perfused term human placenta.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Carcinog | 2008 |
Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion.
Topics: Adenocarcinoma; Antipyrine; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cas | 2011 |
Cadmium inhibits ABCG2 transporter function in BeWo choriocarcinoma cells and MCF-7 cells overexpressing ABCG2.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cadmium | 2012 |
cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; DNA, Complementary; Female; Imidazoles; Lact | 2002 |
Equivocal impact of transplacental and lactational exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, on prostate and colon lesion development in F344 rats.
Topics: Animals; Carcinogens; Colonic Diseases; Colonic Neoplasms; Female; Imidazoles; Immunohistochemistry; | 2005 |
Increased risk of mammary carcinoma development following transplacental and trans-breast milk exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley rats.
Topics: Animals; Carcinogens; DNA Adducts; Female; Fetus; Imidazoles; Male; Mammary Neoplasms, Experimental; | 1995 |
Transfer of the food mutagen PhIP to foetuses and newborn mice following maternal exposure.
Topics: Animals; Animals, Newborn; Autoradiography; Carcinogens; Chromatography, High Pressure Liquid; Femal | 1994 |
Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in Sprague-Dawley rats.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Female; Fibroadenoma; Imidazoles; Incidence; Lactatio | 1996 |