Compounds > 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Precancerous Conditions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Precancerous Conditions in 31 studies

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.

Precancerous Conditions: Pathological conditions that tend eventually to become malignant.

Research Excerpts

ExcerptRelevanceReference
"In the present study, the effect of three controversially discussed risk factors for colorectal cancer, a fat-rich diet (16% raw fat content), dietary folic acid supplementation (50 mg folic acid/kg lab chow) and a human-relevant concentration (0."3.78Influence of a fat-rich diet, folic acid supplementation and a human-relevant concentration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on the induction of preneoplastic lesions in the rat colon. ( Brauer, N; Lampen, A; Nicken, P; Steinberg, P, 2012)
" To distinguish between blocking and suppressing effects, and thus provide mechanistic insights into prevention during the initiation versus post-initiation phases of carcinogenesis, white tea, and green tea were administered at 2% (w/v) as the sole source of drinking fluid either 2 wk before and 2 wk during PhIP dosing (100 mg/kg, every other day by oral gavage), or starting 1 wk after the carcinogen and continued until the study was terminated at 16 wk."1.34Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts. ( Bailey, GS; Carter, O; Dashwood, RH; Dashwood, WM; Fischer, KA; Löhr, CV; Orner, GA; Pereira, CB; Wang, R; Williams, DE, 2007)
" Chronic administration of PhIP or IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of the colon, and short-term treatment leads to the formation of colonic aberrant crypt foci (ACF)."1.30Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis. ( Dashwood, RH; Xu, M, 1999)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.23)18.7374
1990's15 (48.39)18.2507
2000's13 (41.94)29.6817
2010's2 (6.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Narushima, S1
Sakata, T1
Hioki, K1
Itoh, T1
Nomura, T1
Itoh, K1
Nicken, P1
Brauer, N1
Lampen, A1
Steinberg, P2
Ochiai, M7
Ushigome, M1
Fujiwara, K1
Ubagai, T1
Kawamori, T1
Sugimura, T12
Nagao, M7
Nakagama, H5
Fukushima, S2
Wanibuchi, H2
Morimura, K2
Iwai, S1
Nakae, D1
Kishida, H1
Tsuda, H1
Uehara, N1
Imaida, K4
Shirai, T6
Tatematsu, M2
Tsukamoto, T2
Hirose, M1
Furukawa, F1
Watanabe, M3
Nakanishi, M1
Taguchi, A1
Doi, K1
Salim, EI1
Kinoshita, A1
Kudoh, S1
Hirata, K1
Yoshikawa, J1
Ikeda, Y1
Cho, YM1
Takahashi, S3
Tang, M1
Asamoto, M1
Ogawa, K2
Smith-Roe, SL1
Löhr, CV2
Bildfell, RJ1
Fischer, KA2
Hegan, DC1
Glazer, PM1
Buermeyer, AB1
Carter, O1
Dashwood, RH3
Wang, R1
Dashwood, WM1
Orner, GA2
Pereira, CB1
Bailey, GS1
Williams, DE1
Weisburger, JH1
Braley, J1
Reinhardt, J1
Aliaga, C1
Rivenson, A1
Hard, GC1
Zhang, XM1
Takahashi, M2
Esumi, H2
Hasegawa, R2
Sano, M2
Tamano, S3
Ito, N5
Kushida, H1
Wakabayashi, K3
Ishiguro, Y3
Kristiansen, E1
Steffensen, IL2
Paulsen, JE2
Eide, TJ2
Alexander, J2
Totsuka, Y1
Masuda, M1
Fukuda, K1
Oguri, A1
Yazawa, K1
Kozaki, K1
Nishikawa, Y1
Yamamoto, M1
Fukami, H1
Inoue, M1
Chewonarin, T1
Kinouchi, T1
Kataoka, K1
Arimochi, H1
Kuwahara, T1
Vinitketkumnuen, U1
Ohnishi, Y1
Xu, M2
Souda, K1
Purewal, M1
Velasco, M1
Fretland, AJ2
Hein, DW2
Wargovich, MJ1
Feng, Y1
Devanaboyina, US1
Hagiwara, A2
Miyashita, K1
Nakanishi, T1
Kadota, T1
Koda, T2
Nakamura, M2
Yoshino, H1
Ichihara, T1
Kawabe, M1
Aoki, H1
Santana-Rios, G1
Izquierdo-Pulido, M1
Iwasaki, S1
Kim, DJ1
Ohshima, H1
Tudek, B1
Bird, RP1
Bruce, WR1
Kühnel, D1
Taugner, F1
Scholtka, B1

Other Studies

31 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Precancerous Conditions

ArticleYear
Inhibitory effect of yogurt on aberrant crypt foci formation in the rat colon and colorectal tumorigenesis in RasH2 mice.
    Experimental animals, 2010, Volume: 59, Issue:4

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colorectal Neoplasms; Disease Models, Animal;

2010
Influence of a fat-rich diet, folic acid supplementation and a human-relevant concentration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on the induction of preneoplastic lesions in the rat colon.
    Archives of toxicology, 2012, Volume: 86, Issue:5

    Topics: Aberrant Crypt Foci; Animals; Colon; Colorectal Neoplasms; Diet, High-Fat; Dietary Supplements; Foli

2012
Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
    The American journal of pathology, 2003, Volume: 163, Issue:4

    Topics: Adenocarcinoma; Adenoma; Animals; beta Catenin; Carcinogens; Cell Division; Colon; Colonic Neoplasms

2003
Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 80, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Colon; Colonic Neoplasms; Deoxyguanosine; DNA Add

2004
Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats.
    Cancer letters, 2005, Mar-18, Volume: 220, Issue:1

    Topics: Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Imidazoles; Male; Methylene Blue; Pr

2005
Lack of large intestinal carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine at low doses in rats initiated with azoxymethane.
    International journal of cancer, 2005, Jul-20, Volume: 115, Issue:6

    Topics: Animals; Azo Compounds; Carcinogens; Dose-Response Relationship, Drug; Imidazoles; Intestinal Neopla

2005
Equivocal impact of transplacental and lactational exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, on prostate and colon lesion development in F344 rats.
    Cancer letters, 2005, Jun-16, Volume: 224, Issue:1

    Topics: Animals; Carcinogens; Colonic Diseases; Colonic Neoplasms; Female; Imidazoles; Immunohistochemistry;

2005
Induction of aberrant crypt foci in DNA mismatch repair-deficient mice by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP).
    Cancer letters, 2006, Nov-28, Volume: 244, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinogens; Carrier Proteins; Colon; Colonic Neoplas

2006
Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts.
    Nutrition and cancer, 2007, Volume: 58, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Caffeine; Carcinogens; Catechin; Cell Division; Colon; Colonic Neo

2007
The role of fat and calcium in the production of foci of aberrant crypts in the colon of rats fed 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine.
    Environmental health perspectives, 1994, Volume: 102 Suppl 6

    Topics: Animals; Calcium, Dietary; Carcinogens; Colonic Neoplasms; Diet; Dietary Fats; Evaluation Studies as

1994
Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats.
    Carcinogenesis, 1993, Volume: 14, Issue:12

    Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dose-Response Relati

1993
DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis.
    Carcinogenesis, 1996, Volume: 17, Issue:1

    Topics: Animals; Carcinogens; Cell Division; Colonic Neoplasms; DNA Adducts; Female; Imidazoles; Male; Mutag

1996
Efficient method for rapid induction of aberrant crypt foci in rats with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:10

    Topics: Animals; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Dietary Fats; Imidazoles; Male; Precanc

1996
The role of aberrant crypt foci induced by the two heterocyclic amines 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) in the development of colon cancer in mice.
    Cancer letters, 1996, Dec-20, Volume: 110, Issue:1-2

    Topics: Animals; Carcinogens; Colon; Colonic Neoplasms; Female; Imidazoles; Mice; Mice, Inbred C57BL; Neopla

1996
An overview of cancer prevention.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 1996, Volume: 5 Suppl 2

    Topics: beta Carotene; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Environmental Exposure

1996
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine increases the numbers of tumors, cystic crypts and aberrant crypt foci in multiple intestinal neoplasia mice.
    Carcinogenesis, 1997, Volume: 18, Issue:5

    Topics: Animals; Female; Genes, APC; Imidazoles; Intestinal Neoplasms; Intestine, Large; Intestine, Small; M

1997
Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA).
    Carcinogenesis, 1997, Volume: 18, Issue:10

    Topics: Animals; Carcinogens; Colon; Colonic Neoplasms; DNA Adducts; Docosahexaenoic Acids; Imidazoles; Male

1997
Strain differences of rats in the susceptibility to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine: no implication of Apc and Pla2g2a genetic polymorphisms in differential susceptibility.
    Carcinogenesis, 1999, Volume: 20, Issue:6

    Topics: Animals; Base Sequence; Carcinogens; Colon; Colonic Neoplasms; DNA Adducts; DNA Primers; Genes, APC;

1999
Development and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat large intestine.
    Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:7

    Topics: Animals; Colonic Neoplasms; Imidazoles; Intestine, Large; Male; Mutagenicity Tests; Mutagens; Precan

1999
Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-ph
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1999, Volume: 37, Issue:6

    Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Azoxymethane; Chemoprevention; Colonic Neopl

1999
Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Chlorophyllides; Colon; Colonic Neoplasms;

1999
Genetic analysis of the susceptibility in rats to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine, PhIP.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Animals; Carcinogens; Colon; Colonic Diseases; Genetic Predisposition to Disease; Imidazoles; Precan

1999
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred rats.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2000, Volume: 9, Issue:5

    Topics: Acetylation; Animals; Colorectal Neoplasms; Humans; Hydroxylation; Imidazoles; Intestinal Mucosa; Ma

2000
DNA adduct levels and intestinal lesions in congenic rapid and slow acetylator syrian hamsters admi food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).
    Pharmacology & toxicology, 2000, Volume: 86, Issue:6

    Topics: Acetylation; Adenoma; Animals; Animals, Congenic; Arylamine N-Acetyltransferase; Cricetinae; DNA Add

2000
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.
    Cancer letters, 2001, Sep-28, Volume: 171, Issue:1

    Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Administration, Oral; Anim

2001
Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
    The Journal of toxicological sciences, 2002, Volume: 27, Issue:1

    Topics: 1,2-Dimethylhydrazine; Adenoma; Administration, Oral; Animals; Anthocyanins; Anticarcinogenic Agents

2002
Inhibition by white tea of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced colonic aberrant crypts in the F344 rat.
    Nutrition and cancer, 2001, Volume: 41, Issue:1-2

    Topics: Animals; Anticarcinogenic Agents; Colon; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-45

2001
Dose-dependent formation of preneoplastic foci and DNA adducts in rat liver with 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
    Carcinogenesis, 1992, Volume: 13, Issue:8

    Topics: Animals; Carbolines; DNA; DNA Damage; Dose-Response Relationship, Drug; Glutathione Transferase; Imi

1992
Induction of aberrant crypt foci in the large intestine of F344 rats by oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
    Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:2

    Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Dimethylhydrazines; Imidazoles; Intestine, Lar

1991
Foci of aberrant crypts in the colons of mice and rats exposed to carcinogens associated with foods.
    Cancer research, 1989, Mar-01, Volume: 49, Issue:5

    Topics: Animals; Carcinogens, Environmental; Colon; Colonic Neoplasms; Diet; Dose-Response Relationship, Dru

1989
Inflammation does not precede or accompany the induction of preneoplastic lesions in the colon of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-fed rats.
    Archives of toxicology, 2009, Volume: 83, Issue:8

    Topics: Aminopyridines; Animals; Carcinogens; Colitis; Colon; Colonic Neoplasms; Hyperplasia; Imidazoles; Ma

2009