2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Parkinsonian Disorders in 1 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These results suggest that neuromelanin has a critical role in HAA toxicity and adverse effects on mitochondria." | 1.56 | Neuromelanin formation exacerbates HAA-induced mitochondrial toxicity and mitophagy impairments. ( Cannon, JR; Foguth, RM; Lawana, V; Um, SY, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lawana, V | 1 |
| Um, SY | 1 |
| Foguth, RM | 1 |
| Cannon, JR | 1 |
1 other study available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Parkinsonian Disorders
| Article | Year |
|---|---|
Neuromelanin formation exacerbates HAA-induced mitochondrial toxicity and mitophagy impairments.
Topics: Cell Line, Tumor; Energy Metabolism; Harmine; Humans; Imidazoles; Melanins; Membrane Potential, Mito | 2020 |