2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Neoplasms in 18 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response modelling of the data for these three tumour types gives BMDL10 values of 0." | 2.46 | Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine). ( Carthew, P; DiNovi, M; Setzer, RW, 2010) |
| "In a case-control study of breast cancer well-done red meat and PhIP was associated with increased risk of breast cancer." | 2.41 | An epidemiologic approach to studying heterocyclic amines. ( Sinha, R, 2002) |
| "Four of eight tumors had a total of five mutations in the Apc gene, four of which featured a guanine deletion from 5'-GTGGGAT-3' sequences." | 2.39 | Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals. ( Nagao, M; Sugimura, T; Totsuka, Y; Toyota, M; Ushijima, T; Wakabayashi, K, 1996) |
| "Estimating the cancer risk posed by heterocyclic amines depends on measuring how chemical dose influences measurable indicators of cancer progression." | 2.39 | Assessment of the DNA adduction and pharmacokinetics of PhIP and MeIOx in rodents at doses approximating human exposure using the technique of accelerator mass spectrometry (AMS) and 32P-postlabeling. ( Felton, JS; Frantz, C; McManus, M; Turteltaub, KW; Vogel, JS, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 10 (55.56) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellamri, M | 1 |
| Wang, Y | 1 |
| Yonemori, K | 1 |
| White, KK | 1 |
| Wilkens, LR | 1 |
| Le Marchand, L | 1 |
| Turesky, RJ | 1 |
| Canene-Adams, K | 1 |
| Sfanos, KS | 1 |
| Liang, CT | 1 |
| Yegnasubramanian, S | 1 |
| Nelson, WG | 1 |
| Brayton, C | 1 |
| De Marzo, AM | 1 |
| Carthew, P | 1 |
| DiNovi, M | 1 |
| Setzer, RW | 1 |
| Strickland, PT | 1 |
| Qian, Z | 1 |
| Friesen, MD | 1 |
| Rothman, N | 1 |
| Sinha, R | 2 |
| Nowell, SA | 1 |
| Ahn, J | 1 |
| Ambrosone, CB | 1 |
| Adamson, RH | 1 |
| Thorgeirsson, UP | 1 |
| Sugimura, T | 4 |
| Nagao, M | 3 |
| Wakabayashi, K | 2 |
| Ushijima, T | 1 |
| Toyota, M | 1 |
| Totsuka, Y | 1 |
| Gooderham, NJ | 1 |
| Murray, S | 1 |
| Lynch, AM | 1 |
| Edwards, RJ | 1 |
| Yadollahi-Farsani, M | 1 |
| Bratt, C | 1 |
| Rich, KJ | 1 |
| Zhao, K | 1 |
| Murray, BP | 1 |
| Bhadresa, S | 1 |
| Crosbie, SJ | 1 |
| Boobis, AR | 1 |
| Davies, DS | 1 |
| Turteltaub, KW | 1 |
| Vogel, JS | 1 |
| Frantz, C | 1 |
| Felton, JS | 1 |
| McManus, M | 1 |
| Kadlubar, FF | 1 |
| Huber, WW | 1 |
| Kidd, LC | 1 |
| Stillwell, WG | 1 |
| Yu, MC | 1 |
| Wishnok, JS | 1 |
| Skipper, PL | 1 |
| Ross, RK | 1 |
| Henderson, BE | 1 |
| Tannenbaum, SR | 1 |
| Baghurst, PA | 1 |
| de Boer, JG | 1 |
| Zhang, XM | 1 |
| Liu, ZC | 1 |
11 reviews available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Neoplasms
| Article | Year |
|---|---|
Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine).
Topics: Animals; Breast Neoplasms; Carcinogens; Colonic Neoplasms; Cooking; Data Interpretation, Statistical | 2010 |
Metabolites of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) in human urine after consumption of charbroiled or fried beef.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; Cooking; Dietary Proteins; Eating; Glucu | 2002 |
An epidemiologic approach to studying heterocyclic amines.
Topics: Amines; Animals; Carcinogens; Cooking; Diet; Dietary Proteins; Epidemiologic Studies; Heterocyclic C | 2002 |
Gene-nutrient interactions in cancer etiology.
Topics: Carcinogens; Diet; Fruit; Genetic Predisposition to Disease; Humans; Imidazoles; Meat; Neoplasms; Ni | 2004 |
PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine).
Topics: Animals; Carcinogens; Cooking; Food; Humans; Imidazoles; Meat; Mutagenicity Tests; Neoplasms | 1993 |
Extrapolation of heterocyclic amine carcinogenesis data from rodents and nonhuman primates to humans.
Topics: Amines; Animals; Biotransformation; Carcinogens; Diet; Food Handling; Heterocyclic Compounds; Humans | 1996 |
Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals.
Topics: Amines; Animals; Carcinogens, Environmental; DNA Adducts; Environmental Exposure; Food Contamination | 1996 |
Heterocyclic amines: evaluation of their role in diet associated human cancer.
Topics: Animals; Biological Availability; Carcinogens; Diet; Humans; Imidazoles; Meat; Mutagens; Neoplasms; | 1996 |
Assessment of the DNA adduction and pharmacokinetics of PhIP and MeIOx in rodents at doses approximating human exposure using the technique of accelerator mass spectrometry (AMS) and 32P-postlabeling.
Topics: Animals; Carcinogens; DNA Adducts; Humans; Imidazoles; Mass Spectrometry; Mutagens; Neoplasms; Phosp | 1995 |
A new approach to risk estimation of food-borne carcinogens--heterocyclic amines--based on molecular information.
Topics: Amines; Animals; Carcinogens; Cytogenetic Analysis; DNA Adducts; Female; Food; Genetic Predispositio | 1999 |
Protection by dietary compounds against mutation in a transgenic rodent.
Topics: Aflatoxin B1; Animals; Animals, Genetically Modified; Bacterial Proteins; Benzo(a)pyrene; Carcinogen | 2001 |
7 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Neoplasms
| Article | Year |
|---|---|
Biomonitoring an albumin adduct of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in humans.
Topics: Biomarkers; Carcinogens; Cooking; Cytochrome P-450 CYP1A2; Environmental Monitoring; Female; Hair; H | 2018 |
Dietary chemoprevention of PhIP induced carcinogenesis in male Fischer 344 rats with tomato and broccoli.
Topics: Animal Feed; Animals; Body Weight; Brassica; Carcinogens; Cell Transformation, Neoplastic; Chemoprev | 2013 |
An overview of cancer prevention.
Topics: beta Carotene; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Environmental Exposure | 1996 |
[letter].
Topics: Anticarcinogenic Agents; beta Carotene; Chemoprevention; Diet; Humans; Imidazoles; Neoplasms; Risk F | 1998 |
Urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in White, African-American, and Asian-American men in Los Angeles County.
Topics: Adult; Asian; Black People; Humans; Imidazoles; Los Angeles; Male; Meat; Neoplasms; Quinoxalines; Su | 1999 |
Polycyclic aromatic hydrocarbons and heterocyclic amines in the diet: the role of red meat.
Topics: Animals; Carcinogens; Cattle; Diet; Dietary Fats; Hot Temperature; Humans; Imidazoles; Meat; Neoplas | 1999 |
Mutagenic and carcinogenic heterocyclic amines in Chinese cooked foods.
Topics: China; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cooking; Diet; Food Analy | 1988 |