2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Liver Neoplasms in 10 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cultures of primary hepatocytes and hepatoma cell line HepG2 are frequently used in in vitro models for human biotransformation studies." | 1.32 | Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. ( Bader, A; Stahl, F; Wilkening, S, 2003) |
| " Because H and E sections of the myocardium from IQ-treated animals demonstrated inflammatory infiltrate and studies of IQ-DNA adducts in monkeys, by the 32P-postlabeling method, showed high levels of adducts in the heart a systematic study of cardiac pathologic changes associated with chronic administration of IQ was undertaken." | 1.29 | Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates. ( Adamson, RH; Dalgard, DW; Farb, A; Snyderwine, EG; Sugimura, T; Takayama, S; Thorgeirsson, SS; Thorgeirsson, UP; Virmani, R, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haza, AI | 1 |
| Morales, P | 1 |
| Zheng, ZP | 1 |
| Yan, Y | 1 |
| Xia, J | 1 |
| Zhang, S | 1 |
| Wang, M | 1 |
| Chen, J | 1 |
| Xu, Y | 1 |
| Wilkening, S | 1 |
| Stahl, F | 1 |
| Bader, A | 1 |
| Hirata, A | 1 |
| Tsukamoto, T | 1 |
| Sakai, H | 1 |
| Takasu, S | 1 |
| Ban, H | 1 |
| Imai, T | 1 |
| Totsuka, Y | 1 |
| Nishigaki, R | 1 |
| Wakabayashi, K | 1 |
| Yanai, T | 1 |
| Masegi, T | 1 |
| Tatematsu, M | 1 |
| Adamson, RH | 1 |
| Farb, A | 1 |
| Virmani, R | 1 |
| Snyderwine, EG | 1 |
| Thorgeirsson, SS | 1 |
| Takayama, S | 1 |
| Sugimura, T | 1 |
| Dalgard, DW | 1 |
| Thorgeirsson, UP | 1 |
| Shen, CL | 1 |
| Purewal, M | 1 |
| San Francisco, S | 1 |
| Pence, BC | 1 |
| Hammons, GJ | 1 |
| Fletcher, JV | 1 |
| Stepps, KR | 1 |
| Smith, EA | 1 |
| Balentine, DA | 1 |
| Harbowy, ME | 1 |
| Kadlubar, FF | 1 |
| Chewonarin, T | 1 |
| Kinouchi, T | 1 |
| Kataoka, K | 1 |
| Arimochi, H | 1 |
| Kuwahara, T | 1 |
| Vinitketkumnuen, U | 1 |
| Ohnishi, Y | 1 |
| Hirose, M | 1 |
| Takahashi, S | 1 |
| Ogawa, K | 1 |
| Futakuchi, M | 1 |
| Shirai, T | 1 |
| Shibutani, M | 1 |
| Uneyama, C | 1 |
| Toyoda, K | 1 |
| Iwata, H | 1 |
| Knasmüller, S | 1 |
| Schwab, CE | 1 |
| Land, SJ | 1 |
| Wang, CY | 1 |
| Sanyal, R | 1 |
| Kundi, M | 1 |
| Parzefall, W | 1 |
| Darroudi, F | 1 |
10 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Liver Neoplasms
| Article | Year |
|---|---|
Spanish honeys protect against food mutagen-induced DNA damage.
Topics: Anticarcinogenic Agents; Benzo(a)pyrene; Cell Survival; Comet Assay; DNA Breaks; DNA Damage; Ericace | 2013 |
A phenylacetaldehyde-flavonoid adduct, 8-C-(E-phenylethenyl)-norartocarpetin, exhibits intrinsic apoptosis and MAPK pathways-related anticancer potential on HepG2, SMMC-7721 and QGY-7703.
Topics: Acetaldehyde; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Flavonoids; Food Handling; Hep G2 | 2016 |
Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties.
Topics: 7-Alkoxycoumarin O-Dealkylase; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line, Tumor; Comet As | 2003 |
Carcinogenic risk of heterocyclic amines in combination - assessment with a liver initiation model.
Topics: Amines; Animals; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA, Complementary; | 2008 |
Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates.
Topics: Administration, Oral; Animals; Carcinogens; Cooking; DNA Adducts; Fibrosis; Heart; Hot Temperature; | 1995 |
Absence of PhIP adducts, p53 and Apc mutations, in rats fed a cooked beef diet containing a high level of heterocyclic amines.
Topics: Animals; Base Sequence; Carcinogens; Cattle; Colonic Neoplasms; Cooking; DNA Primers; Genes, APC; Ge | 1998 |
Effects of chemoprotective agents on the metabolic activation of the carcinogenic arylamines PhIP and 4-aminobiphenyl in human and rat liver microsomes.
Topics: Aminobiphenyl Compounds; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Diterpenes; Es | 1999 |
Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-ph
Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Azoxymethane; Chemoprevention; Colonic Neopl | 1999 |
Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats.
Topics: Animals; Antioxidants; Carcinogens; Catechin; Colonic Neoplasms; Drug Antagonism; Imidazoles; Liver | 1999 |
Genotoxic effects of heterocyclic aromatic amines in human derived hepatoma (HepG2) cells.
Topics: Amines; Animals; Arylamine N-Acetyltransferase; Carbolines; Carcinogens; Carcinoma, Hepatocellular; | 1999 |