2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Invasiveness, Neoplasm in 3 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of the mammary cancer cell lines MCF-7 and T47D with PhIP induces cells to digest and migrate through a reconstituted basement membrane." | 1.37 | The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine promotes invasive behaviour of breast cancer cells. ( Gooderham, NJ; Lauber, SN, 2011) |
| " The current experimental data demonstrate that only a 20-week period of PhIP treatment is sufficient for induction of ventral carcinomas and that long-term pharmacological dosing with testosterone propionate which applied through a Silastic tube embedded in the subcutis after PhIP treatment can induce invasive carcinomas in the anterior prostate and seminal vesicles." | 1.30 | Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate. ( Asamoto, M; Cui, L; Futakuchi, M; Ito, N; Kato, K; Shirai, T; Takahashi, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, R | 1 |
| Chen, YS | 1 |
| Dashwood, WM | 1 |
| Li, Q | 1 |
| Löhr, CV | 1 |
| Fischer, K | 1 |
| Ho, E | 1 |
| Williams, DE | 1 |
| Dashwood, RH | 1 |
| Lauber, SN | 1 |
| Gooderham, NJ | 1 |
| Shirai, T | 1 |
| Cui, L | 1 |
| Takahashi, S | 1 |
| Futakuchi, M | 1 |
| Asamoto, M | 1 |
| Kato, K | 1 |
| Ito, N | 1 |
3 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; Catenins; Cell Movement; Cell Proliferati | 2017 |
The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine promotes invasive behaviour of breast cancer cells.
Topics: Basement Membrane; Breast Neoplasms; Carcinogens; Cathepsin D; Cell Line, Tumor; Cell Movement; Cook | 2011 |
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate.
Topics: Animals; Carcinogens; Drug Synergism; Imidazoles; Male; Neoplasm Invasiveness; Prostatic Neoplasms; | 1999 |