2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Inflammation in 7 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Breast cancer is the most commonly diagnosed malignancy in females, the etiology being multifactorial and includes the role of lifestyle exposure to DNA-damaging chemicals such as dietary carcinogens benzo (a) pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP)." | 1.51 | Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells. ( David, RM; Gooderham, NJ; Malik, DE, 2019) |
| "Inflammation was seen as increased TNFα levels in ob/ob mice." | 1.42 | Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation. ( Hetland, RB; Ngo, HT; Nygaard, UC; Steffensen, IL, 2015) |
| "Considering the increased colon cancer risk associated with chronic colitis, we have therefore examined the effects of long-acting hGly(2)GLP-2, as well as of endogenous GLP-2 using the antagonist hGLP-2(3-33) in two novel models of inflammation-associated colon cancer: rats fed the carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet (HFD) for one or three cycles, and mice with chronic dextran sodium-sulfate (DSS)-induced colitis administered AOM." | 1.38 | Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer. ( Brubaker, PL; El-Zimaity, HM; Trivedi, S; Wiber, SC, 2012) |
| " Because H and E sections of the myocardium from IQ-treated animals demonstrated inflammatory infiltrate and studies of IQ-DNA adducts in monkeys, by the 32P-postlabeling method, showed high levels of adducts in the heart a systematic study of cardiac pathologic changes associated with chronic administration of IQ was undertaken." | 1.29 | Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates. ( Adamson, RH; Dalgard, DW; Farb, A; Snyderwine, EG; Sugimura, T; Takayama, S; Thorgeirsson, SS; Thorgeirsson, UP; Virmani, R, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Malik, DE | 1 |
| David, RM | 1 |
| Gooderham, NJ | 1 |
| Ngo, HT | 1 |
| Hetland, RB | 1 |
| Nygaard, UC | 1 |
| Steffensen, IL | 1 |
| Trivedi, S | 1 |
| Wiber, SC | 1 |
| El-Zimaity, HM | 1 |
| Brubaker, PL | 1 |
| Borowsky, AD | 1 |
| Dingley, KH | 1 |
| Ubick, E | 1 |
| Turteltaub, KW | 1 |
| Cardiff, RD | 1 |
| Devere-White, R | 1 |
| Nakagama, H | 1 |
| Adamson, RH | 1 |
| Farb, A | 1 |
| Virmani, R | 1 |
| Snyderwine, EG | 1 |
| Thorgeirsson, SS | 1 |
| Takayama, S | 1 |
| Sugimura, T | 1 |
| Dalgard, DW | 1 |
| Thorgeirsson, UP | 1 |
| Sliva, D | 1 |
| Loganathan, J | 1 |
| Jiang, J | 1 |
| Jedinak, A | 1 |
| Lamb, JG | 1 |
| Terry, C | 1 |
| Baldridge, LA | 1 |
| Adamec, J | 1 |
| Sandusky, GE | 1 |
| Dudhgaonkar, S | 1 |
1 review available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Inflammation
| Article | Year |
|---|---|
[Risk factors for non-hereditary colonic cancers].
Topics: Alcohol Drinking; Animals; Colonic Neoplasms; Diet; Dietary Fats; Disease Models, Animal; Environmen | 2007 |
6 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Inflammation
| Article | Year |
|---|---|
Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells.
Topics: Benzo(a)pyrene; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cytochrome P-450 CYP1B1; DNA Damage | 2019 |
Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation.
Topics: Animals; Body Weight; Carcinogenesis; Cell Transformation, Neoplastic; Female; Imidazoles; Inflammat | 2015 |
Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer.
Topics: Animals; Azoxymethane; beta Catenin; Blotting, Western; Carcinogens; Colitis; Colonic Neoplasms; Dex | 2012 |
Inflammation and atrophy precede prostatic neoplasia in a PhIP-induced rat model.
Topics: Animals; Atrophy; Carcinogens; Cell Proliferation; Disease Models, Animal; Glutathione Transferase; | 2006 |
Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates.
Topics: Administration, Oral; Animals; Carcinogens; Cooking; DNA Adducts; Fibrosis; Heart; Hot Temperature; | 1995 |
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Apoptosis; Carcinogens; Cell Proliferation; Cell | 2012 |