2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Germinoblastoma in 8 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Experiments were designed to examine the lymphoma-inducing capacity of PhIP and to test the inhibitory effects of oltipraz on PhIP-induced lymphomas in male F344 rats." | 7.69 | Inhibition of 2-Amino-1-methyl-6-phenylimidazo[4,5]pyridine-induced lymphoma formation by oltipraz. ( Kelloff, G; Rao, CV; Reddy, BS; Rivenson, A; Steele, V; Zang, E, 1996) |
| " Experiments were designed to examine the lymphoma-inducing capacity of PhIP and to test the inhibitory effects of oltipraz on PhIP-induced lymphomas in male F344 rats." | 3.69 | Inhibition of 2-Amino-1-methyl-6-phenylimidazo[4,5]pyridine-induced lymphoma formation by oltipraz. ( Kelloff, G; Rao, CV; Reddy, BS; Rivenson, A; Steele, V; Zang, E, 1996) |
| " The results show that PhIP is extremely toxic to XPA(-/-) mice, even at doses 10-fold lower than tolerated by wild-type C57BL/6 mice." | 1.31 | Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice. ( Beems, RB; Hamzink, M; Klein, JC; van Kreijl, CF; van Steeg , H; Zomer, G; Zwart, PE, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rao, CV | 1 |
| Rivenson, A | 1 |
| Zang, E | 1 |
| Steele, V | 1 |
| Kelloff, G | 1 |
| Reddy, BS | 1 |
| Sørensen, IK | 3 |
| Mortensen, A | 3 |
| Kristiansen, E | 3 |
| van Kreijl, C | 2 |
| Adamson, RH | 2 |
| Thorgeirsson, SS | 2 |
| Roebuck, BD | 1 |
| Rogers, AE | 1 |
| Kensler, TW | 1 |
| Klein, JC | 1 |
| Beems, RB | 1 |
| Zwart, PE | 1 |
| Hamzink, M | 1 |
| Zomer, G | 1 |
| van Steeg , H | 1 |
| van Kreijl, CF | 1 |
| Ochiai, M | 1 |
| Imai, H | 1 |
| Sugimura, T | 2 |
| Nagao, M | 1 |
| Nakagama, H | 1 |
| Esumi, H | 1 |
| Ohgaki, H | 1 |
| Kohzen, E | 1 |
| Takayama, S | 1 |
8 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Germinoblastoma
| Article | Year |
|---|---|
Inhibition of 2-Amino-1-methyl-6-phenylimidazo[4,5]pyridine-induced lymphoma formation by oltipraz.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Imidazoles; Intestinal Neoplasms; Lympho | 1996 |
Short-term carcinogenicity testing of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in E(mu)-pim-1 transgenic mice.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Dose-Response Relationship, Drug; Enhancer Elements, Ge | 1996 |
Lymphoma induction by heterocyclic amines in E mu-pim-1 transgenic mice.
Topics: Animals; Carcinogens; Female; Imidazoles; Lymphoma; Male; Mice; Mice, Transgenic; Protein Serine-Thr | 1997 |
Correspondence re: C.V. Rao, et al., Inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced lymphoma formation by oltipraz. Cancer Res., 56: 3395-3398, 1996.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Hematologic Neoplasms; Imidazoles; Lymphoma; Male; P | 1997 |
Effects of long-term feeding with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in C57BL/ByA and E mu-pim-1 mice.
Topics: Animals; Carcinogens; Female; Imidazoles; Lymphoma; Male; Mice; Mice, Inbred C57BL; Species Specific | 1998 |
Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice.
Topics: Adenocarcinoma; Adenoma; Animals; Body Weight; Carcinogens; DNA Mutational Analysis; DNA Repair; Dos | 2001 |
Induction of intestinal tumors and lymphomas in C57BL/6N mice by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Adenoma; Animals; Carcinogens; Female; Imidazoles; Immunohistochemistry; Intestinal Neoplasms; Lymph | 2002 |
Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Animals; Female; Imidazoles; Lymphoma; Male; Mice; Mice, Inbred Strains; Mutagens | 1989 |