2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Genetic Predisposition in 11 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The PhIP-induced colon cancer model in rats, thus contributes as a relevant tool to elucidate genetic factors responsible for susceptibility to colon carcinogenesis in human." | 2.41 | A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP. ( Fujiwara, K; Nagao, M; Nakagama, H; Ochiai, M; Sugimura, T; Tajima, R; Ubagai, T, 2002) |
| "These associations may be modified by genetic susceptibility to RCC." | 1.43 | Gene-environment interaction of genome-wide association study-identified susceptibility loci and meat-cooking mutagens in the etiology of renal cell carcinoma. ( Daniel, CR; Karam, JA; Matin, SF; Melkonian, SC; Tannir, NM; Wood, CG; Wu, X; Ye, Y, 2016) |
| " In the present study, groups of 6-week-old F344 and ACI male rats, the former strain being susceptible to colon carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and the latter being relatively resistant, were subjected to a long-term carcinogenesis experiment using our intermittent feeding protocol of PhIP in combination with a high-fat diet, which serves as a relevant risk factor that promotes the development of colon cancers." | 1.32 | Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat. ( Fujiwara, K; Nagao, M; Nakagama, H; Ochiai, M; Ohki, M; Ohta, T; Sugimura, T; Ubagai, T, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Melkonian, SC | 1 |
| Daniel, CR | 1 |
| Ye, Y | 1 |
| Tannir, NM | 1 |
| Karam, JA | 1 |
| Matin, SF | 1 |
| Wood, CG | 1 |
| Wu, X | 1 |
| Kim, D | 1 |
| Lee, YJ | 1 |
| Ryu, HY | 1 |
| Lee, JH | 1 |
| Kim, HK | 1 |
| Kim, E | 1 |
| Moon, JD | 1 |
| Chang, DD | 1 |
| Yoon, HS | 1 |
| Nakagama, H | 4 |
| Ochiai, M | 4 |
| Ubagai, T | 2 |
| Tajima, R | 1 |
| Fujiwara, K | 2 |
| Sugimura, T | 4 |
| Nagao, M | 5 |
| Ohki, M | 1 |
| Ohta, T | 1 |
| Moonen, HJ | 1 |
| Moonen, EJ | 1 |
| Maas, L | 1 |
| Dallinga, JW | 1 |
| Kleinjans, JC | 1 |
| de Kok, TM | 1 |
| Naito, A | 1 |
| Suzuki, A | 1 |
| Ueda, S | 1 |
| Nomoto, H | 1 |
| Toriyama-Baba, H | 1 |
| Asamoto, M | 1 |
| Tsuda, H | 1 |
| Nowell, SA | 1 |
| Ahn, J | 1 |
| Ambrosone, CB | 1 |
| Ishiguro, Y | 2 |
| Souda, K | 1 |
| Purewal, M | 1 |
| Fretland, AJ | 1 |
| Schut, HA | 1 |
| Hein, DW | 1 |
| Wargovich, MJ | 1 |
3 reviews available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Genetic Predisposition
| Article | Year |
|---|---|
A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP.
Topics: Animals; Carcinogens; Chromosomes; Colonic Neoplasms; Disease Models, Animal; Disease Progression; G | 2002 |
Gene-nutrient interactions in cancer etiology.
Topics: Carcinogens; Diet; Fruit; Genetic Predisposition to Disease; Humans; Imidazoles; Meat; Neoplasms; Ni | 2004 |
A new approach to risk estimation of food-borne carcinogens--heterocyclic amines--based on molecular information.
Topics: Amines; Animals; Carcinogens; Cytogenetic Analysis; DNA Adducts; Female; Food; Genetic Predispositio | 1999 |
1 trial available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Genetic Predisposition
| Article | Year |
|---|---|
CYP1A2 and NAT2 genotype/phenotype relations and urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a human dietary intervention study.
Topics: Administration, Oral; Adolescent; Adult; Arylamine N-Acetyltransferase; Carcinogens; Cooking; Cytoch | 2004 |
7 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Genetic Predisposition