Compounds > 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
Page last updated: 2024-10-21

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Experimental Neoplasms

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Experimental Neoplasms in 16 studies

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (75.00)18.2507
2000's2 (12.50)29.6817
2010's2 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Williamson, R1
Kashiwabara, S1
Kashimoto, N1
Uesaka, T1
Wakabayashi, K3
Kamiya, K1
Watanabe, H1
Hasegawa, R3
Sano, M2
Tamano, S4
Imaida, K3
Shirai, T4
Nagao, M4
Sugimura, T6
Ito, N4
Rumney, CJ1
Rowland, IR1
Coutts, TM1
Randerath, K1
Reddy, R1
Shah, AB1
Ellul, A1
O'Neill, IK1
Von Tungeln, LS1
Bucci, TJ1
Hart, RW1
Kadlubar, FF2
Fu, PP1
Ushijima, T2
Makino, H1
Kakiuchi, H1
Inoue, R1
Takahashi, S2
Hirose, M4
Futakuchi, M1
Matsumoto, K1
Kristiansen, E1
Okonogi, H1
Zhang, XB1
Heddle, JA1
Suzuki, T1
Sofuni, T1
Felton, JS1
Tucker, JD1
Hagiwara, A1
Takahashi, M2
Totsuka, Y1
Masuda, M1
Fukuda, K1
Oguri, A1
Yazawa, K1
Dashwood, RH1
Suzui, M1
Nakagama, H1
Kimoto, N1
Ikeda, Y1
Sakakibara, M1
Tada, M1
Miyauchi, M1
Nishikawa, A1
Furukawa, F1
Kasahara, K1
Nakamura, H1
Schut, HA1
Yao, R1
Sliva, D1
Loganathan, J1
Jiang, J1
Jedinak, A1
Lamb, JG1
Terry, C1
Baldridge, LA1
Adamec, J1
Sandusky, GE1
Dudhgaonkar, S1

Other Studies

16 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Experimental Neoplasms

ArticleYear
Scientists complete miRNA profiling of carcinogen-induced and spinach-fed colon tumors.
    Epigenomics, 2012, Volume: 4, Issue:5

    Topics: Animals; Carcinogens; Colonic Neoplasms; Gene Expression Profiling; Humans; Imidazoles; MicroRNAs; N

2012
Tumor induction by azoxymethane (AOM) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in F344 rat gastric mucosa featuring intestinal metaplasia caused by X-irradiation.
    Journal of experimental & clinical cancer research : CR, 2005, Volume: 24, Issue:2

    Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Carcinoma, Signet Ring Cell; Cytoplasm; Gastric Muc

2005
Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats.
    Carcinogenesis, 1993, Volume: 14, Issue:12

    Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dose-Response Relati

1993
Effects of risk-associated human dietary macrocomponents on processes related to carcinogenesis in human-flora-associated (HFA) rats.
    Carcinogenesis, 1993, Volume: 14, Issue:1

    Topics: Animals; Biotransformation; Cecum; Cocarcinogenesis; Cross-Linking Reagents; Dietary Fats; Dietary F

1993
Inhibitory effect of caloric restriction on tumorigenicity induced by 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) in the CD1 newborn mouse bioassay.
    Cancer letters, 1996, Jul-12, Volume: 104, Issue:2

    Topics: Aminobiphenyl Compounds; Animals; Animals, Newborn; Carcinogens; Diet, Reducing; Energy Intake; Imid

1996
Genetic alterations in HCA-induced tumors.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Animals; Carcinogens; Colonic Neoplasms; Diet; Female; Food; Genes, p53; Genes, ras; Humans; Imidazo

1995
The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.
    Cancer research, 1997, Jan-15, Volume: 57, Issue:2

    Topics: Animals; Carcinogens; Imidazoles; Male; Neoplasms, Experimental; Prostate; Prostatic Hyperplasia; Pr

1997
The role of aberrant crypt foci induced by the two heterocyclic amines 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) in the development of colon cancer in mice.
    Cancer letters, 1996, Dec-20, Volume: 110, Issue:1-2

    Topics: Animals; Carcinogens; Colon; Colonic Neoplasms; Female; Imidazoles; Mice; Mice, Inbred C57BL; Neopla

1996
Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents.
    Carcinogenesis, 1997, Volume: 18, Issue:4

    Topics: Animals; Bacterial Proteins; Carbolines; Cell Division; Escherichia coli Proteins; Female; Genes, AP

1997
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.
    Mutation research, 1997, May-12, Volume: 376, Issue:1-2

    Topics: Adenocarcinoma; Animals; Carcinogens; Chlorophyllides; Colonic Neoplasms; Dose-Response Relationship

1997
Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA).
    Carcinogenesis, 1997, Volume: 18, Issue:10

    Topics: Animals; Carcinogens; Colon; Colonic Neoplasms; DNA Adducts; Docosahexaenoic Acids; Imidazoles; Male

1997
High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.
    Cancer research, 1998, Mar-15, Volume: 58, Issue:6

    Topics: Animals; beta Catenin; Colonic Neoplasms; Cytoskeletal Proteins; DNA, Neoplasm; Imidazoles; Mammary

1998
Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): detection in paraffin-embedded sections and tissue distribution.
    Cancer research, 1998, Oct-01, Volume: 58, Issue:19

    Topics: Administration, Oral; Animals; Carcinogens; Colon; Cross Reactions; DNA Adducts; Enzyme-Linked Immun

1998
Carcinogenic risk assessment of MeIQx and PhIP in a newborn mouse two-stage tumorigenesis assay.
    Cancer letters, 1999, Jul-19, Volume: 142, Issue:1

    Topics: Animals; Animals, Newborn; Biological Assay; Carcinogens; Imidazoles; Mice; Neoplasms, Experimental;

1999
Tea as a potential chemopreventive agent in PhIP carcinogenesis: effects of green tea and black tea on PhIP-DNA adduct formation in female F-344 rats.
    Nutrition and cancer, 2000, Volume: 36, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; DNA Adducts; Female; Imidazoles; Intestinal Mucosa; K

2000
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Apoptosis; Carcinogens; Cell Proliferation; Cell

2012