2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Experimental Mammary Neoplasms in 65 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated mammary carcinogenesis initiated by combined exposure to various doses of radiation and chemical carcinogens." | 1.40 | Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis. ( Doi, K; Imai, T; Imaoka, T; Ishikawa, K; Nishimura, M; Shimada, Y; Tani, S; Ushijima, T; Yamashita, S, 2014) |
| " At 20 weeks after the last dosing of PhIP, all animals were killed and complete autopsy was made." | 1.31 | Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP(1) antagonist, on breast cancer development. ( Kawamori, T; Kondo, K; Maruyama, T; Nakatsugi, S; Ohuchida, S; Sugimura, T; Uchiya, N; Wakabayashi, K; Watanabe, K; Yamamoto, H, 2001) |
| "The carcinogenic potential of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), identified as the most abundant mutagenic heterocyclic amine in cooked meat and fish, was investigated in dose-response studies." | 1.29 | Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies. ( Hasegawa, R; Ito, N; Masui, T; Sano, M; Shirai, T; Tamano, S, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 27 (41.54) | 18.2507 |
| 2000's | 34 (52.31) | 29.6817 |
| 2010's | 3 (4.62) | 24.3611 |
| 2020's | 1 (1.54) | 2.80 |
| Authors | Studies |
|---|---|
| Salim, E | 1 |
| El-Sisi, AE | 2 |
| Sokar, S | 1 |
| El-Sayad, M | 1 |
| Moussa, E | 1 |
| Sokar, SS | 1 |
| El-Sayad, ME | 1 |
| Moussa, EA | 1 |
| Salim, EI | 1 |
| Kaga, C | 1 |
| Takagi, A | 1 |
| Kano, M | 1 |
| Kado, S | 1 |
| Kato, I | 1 |
| Sakai, M | 1 |
| Miyazaki, K | 1 |
| Nanno, M | 1 |
| Ishikawa, F | 2 |
| Ohashi, Y | 1 |
| Toi, M | 1 |
| Imaoka, T | 1 |
| Nishimura, M | 1 |
| Doi, K | 1 |
| Tani, S | 1 |
| Ishikawa, K | 1 |
| Yamashita, S | 2 |
| Ushijima, T | 10 |
| Imai, T | 2 |
| Shimada, Y | 2 |
| Yamagishi, M | 2 |
| Natsume, M | 1 |
| Osakabe, N | 1 |
| Nakamura, H | 1 |
| Furukawa, F | 1 |
| Imazawa, T | 2 |
| Nishikawa, A | 3 |
| Hirose, M | 10 |
| Okochi, E | 5 |
| Miyamoto, K | 1 |
| Wakazono, K | 1 |
| Shima, H | 2 |
| Sugimura, T | 19 |
| Watanabe, N | 4 |
| Christian, AT | 2 |
| Snyderwine, EG | 19 |
| Tucker, JD | 1 |
| Venugopal, M | 2 |
| Yu, M | 8 |
| Shan, L | 6 |
| He, M | 1 |
| Qiu, C | 5 |
| Lee, NH | 1 |
| Liu, ET | 1 |
| Cho, YM | 3 |
| Takahashi, S | 4 |
| Asamoto, M | 3 |
| Suzuki, S | 1 |
| Inaguma, S | 1 |
| Hokaiwado, N | 3 |
| Shirai, T | 14 |
| Kitamura, Y | 1 |
| Okazaki, K | 1 |
| Son, HY | 1 |
| Iwata, T | 2 |
| Yamauchi, Y | 1 |
| Kasai, M | 2 |
| Tsutsumi, K | 1 |
| Schut, HA | 3 |
| Haba, R | 1 |
| Watanabe, S | 1 |
| Wada, M | 1 |
| Udaka, S | 1 |
| Sugie, S | 6 |
| Ohnishi, M | 3 |
| Ushida, J | 1 |
| Yamamoto, T | 1 |
| Hara, A | 1 |
| Koide, A | 1 |
| Mori, Y | 1 |
| Kohno, H | 1 |
| Suzuki, R | 1 |
| Tanaka, T | 1 |
| Wakabayashi, K | 10 |
| Mori, H | 4 |
| Nozawa, H | 1 |
| Nakao, W | 1 |
| Takata, J | 1 |
| Arimoto-Kobayashi, S | 1 |
| Kondo, K | 2 |
| Papaconstantinou, AD | 1 |
| Naiki-Ito, A | 1 |
| Yamashita, H | 1 |
| Tsuda, H | 1 |
| Ogawa, K | 1 |
| Hasegawa, R | 10 |
| Kato, T | 3 |
| Hagiwara, A | 4 |
| Boonyaphiphat, P | 2 |
| Nagao, M | 9 |
| Ito, N | 10 |
| Kimura, J | 2 |
| Yaono, M | 3 |
| Futakuchi, M | 3 |
| Fukutake, M | 1 |
| Fukutome, K | 1 |
| Akagi, K | 1 |
| Satoh, T | 1 |
| Hara, Y | 1 |
| el-Bayoumy, K | 1 |
| Chae, YH | 1 |
| Upadhyaya, P | 1 |
| Rivenson, A | 2 |
| Kurtzke, C | 1 |
| Reddy, B | 1 |
| Hecht, SS | 1 |
| Ghoshal, A | 1 |
| Preisegger, KH | 1 |
| Takayama, S | 2 |
| Thorgeirsson, SS | 1 |
| Ochiai, M | 2 |
| Kushida, H | 1 |
| Sano, M | 3 |
| Tamano, S | 5 |
| Imaida, K | 4 |
| Toyota, M | 2 |
| Weisburger, JH | 1 |
| Hosoya, Y | 1 |
| Canzian, F | 1 |
| Imai, K | 1 |
| Davis, CD | 2 |
| Masui, T | 2 |
| Makino, H | 1 |
| Kakiuchi, H | 1 |
| Inoue, R | 1 |
| Ino, N | 1 |
| Yada, H | 1 |
| Suzui, N | 2 |
| Rahman, KM | 1 |
| Yoshimi, N | 1 |
| Roberts-Thomson, SJ | 5 |
| Dashwood, RH | 1 |
| Suzui, M | 1 |
| Nakagama, H | 3 |
| Thorgeirsson, UP | 1 |
| Yamada, S | 1 |
| Kuramoto, T | 2 |
| Serikawa, T | 1 |
| Okada, K | 1 |
| Sato, K | 1 |
| Josyula, S | 1 |
| Tanaka, H | 1 |
| Kawabe, M | 1 |
| Kaneko, H | 1 |
| Matsui, M | 1 |
| Rahman, W | 1 |
| Ryu, DY | 1 |
| Ohta, T | 4 |
| Nakatsugi, S | 3 |
| Watanabe, K | 4 |
| Kawamori, T | 4 |
| Morotomi, M | 1 |
| Toda, T | 1 |
| Yamaguchi, T | 1 |
| Lin, C | 1 |
| Kimoto, N | 2 |
| Kono, T | 1 |
| Nishibe, S | 1 |
| Mutoh, M | 1 |
| Tanigawa, T | 1 |
| Uchiya, N | 2 |
| Fretland, AJ | 1 |
| Devanaboyina, US | 1 |
| Nangju, NA | 1 |
| Leff, MA | 1 |
| Xiao, GH | 1 |
| Webb, SJ | 1 |
| Doll, MA | 1 |
| Hein, DW | 1 |
| Hirayama, Y | 1 |
| Yanagihara, K | 1 |
| Yoshida, MC | 1 |
| Mochizuki, M | 1 |
| Ohuchida, S | 1 |
| Yamamoto, H | 1 |
| Maruyama, T | 1 |
| Cheng, JL | 1 |
| Tokudome, S | 1 |
| Shibutani, M | 1 |
| Morimura, K | 1 |
| Ohki, M | 1 |
| Fukushima, S | 1 |
| Esumi, H | 1 |
5 reviews available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Single nucleotide instability: a wide involvement in human and rat mammary carcinogenesis?
Topics: Animals; Bacterial Proteins; Base Pair Mismatch; Carcinogens; DNA, Neoplasm; Escherichia coli Protei | 2002 |
Mammary gland carcinogenesis by food-derived heterocyclic amines and studies on the mechanisms of carcinogenesis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Topics: Animals; Carcinogens; Cooking; DNA Adducts; DNA, Neoplasm; Food; Humans; Imidazoles; Mammary Neoplas | 2002 |
Mammary gland carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats: possible mechanisms.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Division; DNA Adducts; Female; Imidazoles; Mammary | 1999 |
Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in mice and rats.
Topics: Adenocarcinoma; Animals; Carcinogens; DNA Damage; Female; Forecasting; Genes, p53; Hypoxanthine Phos | 2002 |
Mammary gland carcinogenesis by food-derived heterocyclic amines: metabolism and additional factors influencing carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Topics: Animals; Carcinogens; Diet; Female; Humans; Imidazoles; Mammary Neoplasms, Animal; Mammary Neoplasms | 2002 |
60 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Metformin potentiates the chemotherapeutic effects of doxorubicin on 2-amino-1-methyl-6-phenylimidazo[4,5b] pyridine-induced Mammary Carcinoma in rats.
Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Drug Synergism; Female; Hypoglycemic Agents; Imid | 2021 |
Anticancer effect of metformin against 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine-induced rat mammary carcinogenesis is through AMPK pathway and modulation of oxidative stress markers.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Carcinogenesis; Carcinogens; Choleste | 2019 |
Lactobacillus casei Shirota enhances the preventive efficacy of soymilk in chemically induced breast cancer.
Topics: Animals; Anticarcinogenic Agents; Female; Imidazoles; Ki-67 Antigen; Lacticaseibacillus casei; Liver | 2013 |
Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis.
Topics: Animals; Carcinogenesis; Carcinogens; Female; Imidazoles; Incidence; Mammary Neoplasms, Experimental | 2014 |
Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats.
Topics: Adenocarcinoma; Adenoma; Animals; Anthocyanins; Anticarcinogenic Agents; Antineoplastic Agents, Phyt | 2002 |
Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinomas.
Topics: Animals; BRCA1 Protein; Carcinogens; Carcinoma; Disease Models, Animal; DNA Methylation; Female; Imi | 2002 |
Comparative genomic hybridization analysis of PhIP-induced mammary carcinomas in rats reveals a cytogenetic signature.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Chromosome Aberrations; Chromosomes; DNA, Ne | 2002 |
cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; DNA, Complementary; Female; Imidazoles; Lact | 2002 |
A cytogenetic footprint for mammary carcinomas induced by PhIP in rats.
Topics: Animals; Carcinogens; DNA Footprinting; Female; Food Analysis; Imidazoles; Mammary Neoplasms, Experi | 2002 |
Allelic imbalance and altered expression of genes in chromosome 2q11-2q16 from rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Allelic Imbalance; Animals; Carcinogens; Centromere; Chromosome Mapping; Computer Systems; Crosses, | 2003 |
Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: lack of influence of carcinogen or testosterone treatment.
Topics: Adenocarcinoma; Age Factors; Aminobiphenyl Compounds; Androgen Antagonists; Androgen-Binding Protein | 2003 |
Deregulation of the cyclin D1/Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Animals; Blotting, Western; Carcinogens; Cell Cycle; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-De | 2003 |
Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.
Topics: 4-Butyrolactone; Animals; Anticarcinogenic Agents; Carcinogens; Female; Glucosides; Imidazoles; Lign | 2003 |
Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas.
Topics: Adenoma; Amino Acid Sequence; Animals; Base Sequence; Carcinogens; Carcinoma; Cell Differentiation; | 2003 |
Susceptibility of rats to mammary gland carcinogenesis by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) varies with age and is associated with the induction of differential gene expression.
Topics: Aging; Animals; Carcinogens; Cell Differentiation; Cell Division; Cluster Analysis; Disease Suscepti | 2004 |
Effects of lactoferrin, soya germ and polyamine on 2-amino-1-methyl-6- phenylimidazo[4,5-b]-pyridine(PhIP)- induced breast carcinogenesis in rats.
Topics: Animals; Carcinogens; Cell Division; Disease Models, Animal; Female; Glycine max; Imidazoles; Lactof | 2004 |
Steroid hormone receptor expression and proliferation in rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Animals; Carcinogens; Cell Cycle; Cell Nucleus; Cell Proliferation; Cyclin D1; Epithelial Cells; Est | 2005 |
Effect of alpha-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats.
Topics: 1-Naphthylisothiocyanate; Adenocarcinoma; Animals; Carcinogens; Diet; Drug Therapy, Combination; Fem | 2005 |
Inhibition of PhIP-induced mammary carcinogenesis in female rats by ingestion of freeze-dried beer.
Topics: Animals; Beer; Body Weight; Carcinogens; Cytochrome P-450 CYP1A2; Dietary Fats; Dietary Supplements; | 2006 |
Proliferation and apoptosis in PhIP-induced rat mammary gland carcinomas with elevated phosphotyrosine-STAT5a.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogens; Cell Proliferation; Cyclin D; Cyclins; | 2007 |
Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Aged; Animals; Animals, Genetically Modified; Blotting, Wes | 2007 |
Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Chlorophyllides; Female; Imidazoles; Mammary Neoplasm | 1995 |
Increased risk of mammary carcinoma development following transplacental and trans-breast milk exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley rats.
Topics: Animals; Carcinogens; DNA Adducts; Female; Fetus; Imidazoles; Male; Mammary Neoplasms, Experimental; | 1995 |
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Antioxidants; Body Weight; Carcinogens; Female; Fi | 1995 |
Comparative tumorigenicity of benzo[a]pyrene, 1-nitropyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats.
Topics: Animals; Benzo(a)pyrene; Body Weight; Carcinogens; Environmental Pollutants; Female; Imidazoles; Mam | 1995 |
Induction of mammary tumors in female Sprague-Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and effect of dietary fat.
Topics: Animals; Carcinogens; Cocarcinogenesis; Dietary Fats; Female; Imidazoles; Mammary Neoplasms, Experim | 1994 |
Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods.
Topics: Adenocarcinoma; Amines; Animals; Carcinogens; Cooking; Female; Food Analysis; Heterocyclic Compounds | 1994 |
Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats.
Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dose-Response Relati | 1993 |
Microsatellite instability and loss of heterozygosity on chromosome 10 in rat mammary tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Animals; Base Sequence; Carcinogens; DNA, Neoplasm; DNA, Satellite; Female; Gene Deletion; Heterozyg | 1996 |
Analysis of EGFR, TGF-alpha, neu and c-myc in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary tumors using RT-PCR.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinogens; Dietary Fats; DNA Primers; Fe | 1995 |
Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in Sprague-Dawley rats.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Female; Fibroadenoma; Imidazoles; Incidence; Lactatio | 1996 |
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; Diet; DNA Adducts; Dose- | 1995 |
Genetic alterations in HCA-induced tumors.
Topics: Animals; Carcinogens; Colonic Neoplasms; Diet; Female; Food; Genes, p53; Genes, ras; Humans; Imidazo | 1995 |
Lack of inhibitory effect of benzyl isothiocyanate on 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Cocarcinogenesis; Dietary Fats; Female; | 1996 |
Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine.
Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Cell Division; Dose-Response Relationship, Drug; | 1996 |
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.
Topics: Adenocarcinoma; Animals; Carcinogens; Chlorophyllides; Colonic Neoplasms; Dose-Response Relationship | 1997 |
Inhibitory effects of diallyl disulfide or aspirin on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary carcinogenesis in rats.
Topics: Administration, Oral; Allyl Compounds; Animals; Anticarcinogenic Agents; Aspirin; Carcinogens; Corn | 1997 |
Effect of dietary fat on codon 12 and 13 Ha-ras gene mutations in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors.
Topics: Animals; Base Sequence; Carcinogens; Codon; Dietary Fats, Unsaturated; Female; Genes, ras; Imidazole | 1997 |
High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.
Topics: Animals; beta Catenin; Colonic Neoplasms; Cytoskeletal Proteins; DNA, Neoplasm; Imidazoles; Mammary | 1998 |
Proliferation, development and DNA adduct levels in the mammary gland of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a high fat diet.
Topics: Animals; Carcinogens; Cell Division; Cocarcinogenesis; Dietary Fats; DNA Adducts; Female; Imidazoles | 1998 |
Mammary gland carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Sprague-Dawley rats on high- and low-fat diets.
Topics: Animals; Carcinogens; Diet, Fat-Restricted; Dietary Fats; Female; Imidazoles; Immunohistochemistry; | 1998 |
Linkage mapping of the Bra, Brb and Brg genes for rat protein phosphatase 2A 55 kDa B-regulatory subunit isotypes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animal Feed; Animals; Base Sequence; Carcinog | 1998 |
mRNA differential display of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors.
Topics: Animals; Carcinogens; Caseins; Dietary Fats; Disease Models, Animal; Female; Gene Expression Regulat | 1998 |
Effects of dietary conjugated linoleic acid on DNA adduct formation of PhIP and IQ after bolus administration to female F344 rats.
Topics: Acetyl-CoA C-Acetyltransferase; Animals; Anticarcinogenic Agents; Carcinogens; Dietary Fats, Unsatur | 1998 |
Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants alpha-tocopherol and n-tritriacontane-16,18-dione, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary and colonic carcinogenesis in female F344
Topics: Adenocarcinoma; Adenoma; Animals; Antioxidants; Caffeine; Carcinogens; Chemoprevention; Colonic Neop | 1999 |
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine-induced mammary carcinogenesis in rats.
Topics: Allyl Compounds; Animals; Anticarcinogenic Agents; Aspirin; Benzoflavones; beta-Naphthoflavone; Carc | 1999 |
Genomic imbalance in rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine.
Topics: Animals; Carcinogens; Diet, Fat-Restricted; Dietary Fats; DNA Mutational Analysis; DNA, Neoplasm; Fe | 2000 |
Inhibitory effects of Bifidobacterium-fermented soy milk on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinogenesis, with a partial contribution of its component isoflavones.
Topics: Animals; Anticarcinogenic Agents; Bifidobacterium; Carcinogens; Female; Fermentation; Glycine max; I | 2000 |
Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats.
Topics: Animals; Biological Assay; Body Weight; Carcinogens; Carcinoma; Colonic Neoplasms; Diet; Drugs, Chin | 2000 |
Chemoprevention by nimesulide, a selective cyclooxygenase-2 inhibitor, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cyclooxygenase Inhibitors; Female; Imidazoles; Immuno | 2000 |
Effects of heterocyclic amines with mammary gland carcinogenic potential on estrogenic response of uterus in ovariectomized rats.
Topics: Animals; Carcinogens; Estradiol; Female; Imidazoles; Mammary Neoplasms, Experimental; Ovariectomy; Q | 2001 |
Characterization of peroxisome proliferator-activated receptor alpha in normal rat mammary gland and 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine-induced mammary gland tumors from rats fed high and low fat diets.
Topics: Animals; Carcinogens; Cocarcinogenesis; Dietary Fats; Dose-Response Relationship, Drug; Female; Gene | 2000 |
Frequent c-Ha-ras gene mutations in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Animals; Carcinogens; Female; Genes, ras; Imidazoles; Mammary Neoplasms, Experimental; Point Mutatio | 2001 |
DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine.
Topics: Acetylation; Administration, Oral; Animals; Animals, Congenic; Arylamine N-Acetyltransferase; Carcin | 2001 |
Single nucleotide instability without microsatellite instability in rat mammary carcinomas.
Topics: Animals; Bacterial Proteins; Base Sequence; Carcinogens; DNA Mutational Analysis; Escherichia coli P | 2001 |
Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP(1) antagonist, on breast cancer development.
Topics: Animals; Apoptosis; Body Weight; Bridged Bicyclo Compounds; Caproates; Carcinogens; Cell Division; F | 2001 |
Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Topics: alpha-Linolenic Acid; Animals; Carcinogens; Cell Division; DNA Adducts; Female; Imidazoles; Linoleic | 2002 |
Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats.
Topics: Animals; Antineoplastic Agents; Carcinogens; Female; Imidazoles; Incidence; Mammary Neoplasms, Anima | 2002 |
Etiology-specific gene expression profiles in rat mammary carcinomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Gene Expression Profiling; Gene Expr | 2002 |
A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Topics: Animals; Colonic Neoplasms; Female; Hot Temperature; Imidazoles; Male; Mammary Neoplasms, Experiment | 1991 |