2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Experimental Hepatoma in 11 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Because H and E sections of the myocardium from IQ-treated animals demonstrated inflammatory infiltrate and studies of IQ-DNA adducts in monkeys, by the 32P-postlabeling method, showed high levels of adducts in the heart a systematic study of cardiac pathologic changes associated with chronic administration of IQ was undertaken." | 1.29 | Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates. ( Adamson, RH; Dalgard, DW; Farb, A; Snyderwine, EG; Sugimura, T; Takayama, S; Thorgeirsson, SS; Thorgeirsson, UP; Virmani, R, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (81.82) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mori, Y | 1 |
| Koide, A | 1 |
| Kobayashi, Y | 1 |
| Furukawa, F | 1 |
| Hirose, M | 1 |
| Nishikawa, A | 1 |
| Cooney, GT | 1 |
| Holcroft, J | 1 |
| de Boer, JG | 1 |
| Adamson, RH | 3 |
| Farb, A | 1 |
| Virmani, R | 1 |
| Snyderwine, EG | 2 |
| Thorgeirsson, SS | 2 |
| Takayama, S | 2 |
| Sugimura, T | 4 |
| Dalgard, DW | 2 |
| Thorgeirsson, UP | 3 |
| Ushijima, T | 1 |
| Makino, H | 1 |
| Kakiuchi, H | 1 |
| Inoue, R | 1 |
| Nagao, M | 2 |
| Dass, SB | 2 |
| Hammons, GJ | 1 |
| Bucci, TJ | 2 |
| Heflich, RH | 2 |
| Casciano, DA | 2 |
| Tsuda, H | 1 |
| Sekine, K | 1 |
| Uehara, N | 1 |
| Takasuka, N | 1 |
| Moore, MA | 1 |
| Konno, Y | 1 |
| Nakashita, K | 1 |
| Degawa, M | 1 |
| Hasegawa, R | 1 |
| Takahashi, S | 1 |
| Shirai, T | 1 |
| Iwasaki, S | 1 |
| Kim, DJ | 1 |
| Ochiai, M | 1 |
| Ito, N | 1 |
| Dooley, KL | 1 |
| Von Tungeln, LS | 1 |
| Bucci, T | 1 |
| Fu, PP | 1 |
| Kadlubar, FF | 1 |
| Schut, HA | 1 |
| Turesky, RJ | 1 |
11 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Experimental Hepatoma
| Article | Year |
|---|---|
Effects of cigarette smoke and a heterocyclic amine, MeIQx on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver.
Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Cocarc | 2003 |
The effect of dietary restriction on PhIP-induced mutation in the distal colon and B[a]P- and ENU-induced mutation in the liver of the rat.
Topics: Animals; Benzo(a)pyrene; Colon; Diet, Reducing; DNA; Ethylnitrosourea; Female; Imidazoles; Liver; Li | 2004 |
Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates.
Topics: Administration, Oral; Animals; Carcinogens; Cooking; DNA Adducts; Fibrosis; Heart; Hot Temperature; | 1995 |
Laparoscopy as a means of monitoring liver tumor induction in nonhuman primates.
Topics: Animals; Carcinogens; Equipment Design; Imidazoles; Laparoscopes; Laparoscopy; Liver Neoplasms, Expe | 1995 |
Genetic alterations in HCA-induced tumors.
Topics: Animals; Carcinogens; Colonic Neoplasms; Diet; Female; Food; Genes, p53; Genes, ras; Humans; Imidazo | 1995 |
Susceptibility of C57BL/6 mice to tumorigenicity induced by dimethylnitrosamine and 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine in the neonatal bioassay.
Topics: Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Cytochrome P-450 CYP2E1; Dimethylnitr | 1998 |
Evaluation of the transgenic p53+/- mouse for detecting genotoxic liver carcinogens in a short-term bioassay.
Topics: Adenoma; Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Chrysenes; Dimethylnitrosami | 1999 |
Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats.
Topics: Animals; Caffeine; Carcinogens; Colonic Neoplasms; Drug Synergism; Imidazoles; Liver Neoplasms, Expe | 1999 |
Dose-dependent formation of preneoplastic foci and DNA adducts in rat liver with 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Topics: Animals; Carbolines; DNA; DNA Damage; Dose-Response Relationship, Drug; Glutathione Transferase; Imi | 1992 |
Comparative carcinogenicity of 4-aminobiphenyl and the food pyrolysates, Glu-P-1, IQ, PhIP, and MeIQx in the neonatal B6C3F1 male mouse.
Topics: Aminobiphenyl Compounds; Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Imidazoles; | 1992 |
Metabolic processing and carcinogenicity of heterocyclic amines in nonhuman primates.
Topics: Animals; Chromatography, High Pressure Liquid; DNA; DNA Damage; Dose-Response Relationship, Immunolo | 1990 |