2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Disease Models, Animal in 21 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As for colon cancer models in rodents, Apc-disrupted mice, including ApcMin, have been one of the most widely utilized animal models to dissect the molecular events implicated in the development of intestinal tumors." | 2.43 | Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP. ( Nakagama, H; Nakanishi, M; Ochiai, M, 2005) |
| "The PhIP-induced colon cancer model in rats, thus contributes as a relevant tool to elucidate genetic factors responsible for susceptibility to colon carcinogenesis in human." | 2.41 | A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP. ( Fujiwara, K; Nagao, M; Nakagama, H; Ochiai, M; Sugimura, T; Tajima, R; Ubagai, T, 2002) |
| " Induction of invasive prostate carcinomas in the rat frequently requires long-term administration of a pharmacological dose of testosterone with or without application of a chemical carcinogen." | 2.41 | Experimental prostate carcinogenesis - rodent models. ( Cui, L; Futakuchi, M; Imaida, K; Kato, K; Shirai, T; Takahashi, S; Tamano, S, 2000) |
| "Chronic colitis was induced by oral administration of dextran sulphate sodium (DSS) to Fischer 344 rats." | 1.43 | Impact of dextran sulphate sodium-induced colitis on the intestinal transport of the colon carcinogen PhIP. ( Breves, G; Giovannini, S; Kershaw, O; Nicken, P; Ostermann, AI; Schebb, NH; Steinberg, P; von Keutz, A; Willenberg, I, 2016) |
| "To develop a relevant mouse model for prostate cancer prevention research, we administered a dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), to CYP1A-humanized mice." | 1.38 | Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice. ( Bosland, MC; Cheung, C; Li, G; Liu, AB; Reuhl, KR; Wang, H; Yang, CS, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 14 (66.67) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Syeda, T | 1 |
| Foguth, RM | 1 |
| Llewellyn, E | 1 |
| Cannon, JR | 1 |
| Canene-Adams, K | 1 |
| Sfanos, KS | 1 |
| Liang, CT | 1 |
| Yegnasubramanian, S | 1 |
| Nelson, WG | 1 |
| Brayton, C | 1 |
| De Marzo, AM | 1 |
| Nicken, P | 1 |
| von Keutz, A | 1 |
| Willenberg, I | 1 |
| Ostermann, AI | 1 |
| Schebb, NH | 1 |
| Giovannini, S | 1 |
| Kershaw, O | 1 |
| Breves, G | 1 |
| Steinberg, P | 1 |
| Chen, JX | 1 |
| Li, G | 2 |
| Wang, H | 2 |
| Liu, A | 1 |
| Lee, MJ | 1 |
| Reuhl, K | 1 |
| Suh, N | 1 |
| Bosland, MC | 2 |
| Yang, CS | 2 |
| Narushima, S | 1 |
| Sakata, T | 1 |
| Hioki, K | 1 |
| Itoh, T | 1 |
| Nomura, T | 1 |
| Itoh, K | 1 |
| Liu, AB | 1 |
| Cheung, C | 1 |
| Reuhl, KR | 1 |
| Okochi, E | 1 |
| Miyamoto, K | 1 |
| Wakazono, K | 1 |
| Shima, H | 1 |
| Sugimura, T | 2 |
| Ushijima, T | 1 |
| Nakagama, H | 3 |
| Ochiai, M | 2 |
| Ubagai, T | 1 |
| Tajima, R | 1 |
| Fujiwara, K | 1 |
| Nagao, M | 1 |
| Tanaka, T | 1 |
| Suzuki, R | 1 |
| Kohno, H | 1 |
| Sugie, S | 1 |
| Takahashi, M | 1 |
| Wakabayashi, K | 1 |
| Haba, R | 1 |
| Watanabe, S | 1 |
| Wada, M | 1 |
| Udaka, S | 1 |
| Ebeler, SE | 1 |
| Dingley, KH | 2 |
| Ubick, E | 2 |
| Abel, S | 1 |
| Mitchell, AE | 1 |
| Burns, SA | 1 |
| Steinberg, FM | 1 |
| Clifford, AJ | 1 |
| Nakanishi, M | 1 |
| Borowsky, AD | 1 |
| Turteltaub, KW | 1 |
| Cardiff, RD | 1 |
| Devere-White, R | 1 |
| Roberts-Thomson, SJ | 1 |
| Snyderwine, EG | 1 |
| Shirai, T | 1 |
| Takahashi, S | 1 |
| Cui, L | 1 |
| Futakuchi, M | 1 |
| Kato, K | 1 |
| Tamano, S | 1 |
| Imaida, K | 1 |
| Fretland, AJ | 2 |
| Devanaboyina, US | 2 |
| Feng, Y | 1 |
| Leff, MA | 2 |
| Xiao, GH | 2 |
| Webb, SJ | 2 |
| Hein, DW | 2 |
| Nangju, NA | 1 |
| Doll, MA | 1 |
| de Boer, JG | 1 |
| Steffensen, IL | 1 |
| Schut, HA | 1 |
| Paulsen, JE | 1 |
| Andreassen, A | 1 |
| Alexander, J | 1 |
| Cavin, C | 1 |
| Holzhaeuser, D | 1 |
| Scharf, G | 1 |
| Constable, A | 1 |
| Huber, WW | 1 |
| Schilter, B | 1 |
6 reviews available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Disease Models, Animal
| Article | Year |
|---|---|
A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP.
Topics: Animals; Carcinogens; Chromosomes; Colonic Neoplasms; Disease Models, Animal; Disease Progression; G | 2002 |
Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Colonic Neoplasms; Dise | 2005 |
[Risk factors for non-hereditary colonic cancers].
Topics: Alcohol Drinking; Animals; Colonic Neoplasms; Diet; Dietary Fats; Disease Models, Animal; Environmen | 2007 |
Experimental prostate carcinogenesis - rodent models.
Topics: Aminobiphenyl Compounds; Animals; Carcinogens; Disease Models, Animal; Imidazoles; Male; Methylnitro | 2000 |
Protection by dietary compounds against mutation in a transgenic rodent.
Topics: Aflatoxin B1; Animals; Animals, Genetically Modified; Bacterial Proteins; Benzo(a)pyrene; Carcinogen | 2001 |
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Ce | 2002 |
15 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Disease Models, Animal
| Article | Year |
|---|---|
PhIP exposure in rodents produces neuropathology potentially relevant to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2020 |
Dietary chemoprevention of PhIP induced carcinogenesis in male Fischer 344 rats with tomato and broccoli.
Topics: Animal Feed; Animals; Body Weight; Brassica; Carcinogens; Cell Transformation, Neoplastic; Chemoprev | 2013 |
Impact of dextran sulphate sodium-induced colitis on the intestinal transport of the colon carcinogen PhIP.
Topics: Animals; Carcinogens; Chromatography, Liquid; Chronic Disease; Colitis; Colonic Neoplasms; Dextran S | 2016 |
Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Cyclooxygenase 2; Cytochrome P-450 CY | 2016 |
Inhibitory effect of yogurt on aberrant crypt foci formation in the rat colon and colorectal tumorigenesis in RasH2 mice.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colorectal Neoplasms; Disease Models, Animal; | 2010 |
Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.
Topics: Animals; Cadherins; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 CYP1A2; Diet, Hig | 2012 |
Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinomas.
Topics: Animals; BRCA1 Protein; Carcinogens; Carcinoma; Disease Models, Animal; DNA Methylation; Female; Imi | 2002 |
Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cycloox
Topics: Adenocarcinoma; Animals; Anticoagulants; Base Sequence; beta Catenin; Carcinogens; Colonic Neoplasms | 2005 |
Effects of lactoferrin, soya germ and polyamine on 2-amino-1-methyl-6- phenylimidazo[4,5-b]-pyridine(PhIP)- induced breast carcinogenesis in rats.
Topics: Animals; Carcinogens; Cell Division; Disease Models, Animal; Female; Glycine max; Imidazoles; Lactof | 2004 |
Animal models and analytical approaches for understanding the relationships between wine and cancer.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Disease Models, Animal; DNA Adducts; Dose-R | 2005 |
Inflammation and atrophy precede prostatic neoplasia in a PhIP-induced rat model.
Topics: Animals; Atrophy; Carcinogens; Cell Proliferation; Disease Models, Animal; Glutathione Transferase; | 2006 |
mRNA differential display of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors.
Topics: Animals; Carcinogens; Caseins; Dietary Fats; Disease Models, Animal; Female; Gene Expression Regulat | 1998 |
Oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) yields PhIP-DNA adducts but not tumors in male Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.
Topics: Acetylation; Animals; Animals, Congenic; Arylamine N-Acetyltransferase; Carcinogens; Cricetinae; Dis | 2001 |
DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine.
Topics: Acetylation; Administration, Oral; Animals; Animals, Congenic; Arylamine N-Acetyltransferase; Carcin | 2001 |
Intestinal tumorigenesis in multiple intestinal neoplasia mice induced by the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: perinatal susceptibility, regional variation, and correlation with DNA adducts.
Topics: Administration, Oral; Age Factors; Animals; Animals, Newborn; Carcinogens; Disease Models, Animal; D | 2001 |