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2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Colorectal Neoplasms, Hereditary Nonpolyposis

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Colorectal Neoplasms, Hereditary Nonpolyposis in 1 studies

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.

Colorectal Neoplasms, Hereditary Nonpolyposis: A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Glaab, WE1
Skopek, TR1

Other Studies

1 other study available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Colorectal Neoplasms, Hereditary Nonpolyposis

ArticleYear
Cytotoxic and mutagenic response of mismatch repair-defective human cancer cells exposed to a food-associated heterocyclic amine.
    Carcinogenesis, 1999, Volume: 20, Issue:3

    Topics: Biotransformation; Carcinogens; Colorectal Neoplasms, Hereditary Nonpolyposis; Food Analysis; Humans

1999