2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Colorectal Cancer in 27 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, the effect of three controversially discussed risk factors for colorectal cancer, a fat-rich diet (16% raw fat content), dietary folic acid supplementation (50 mg folic acid/kg lab chow) and a human-relevant concentration (0." | 3.78 | Influence of a fat-rich diet, folic acid supplementation and a human-relevant concentration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on the induction of preneoplastic lesions in the rat colon. ( Brauer, N; Lampen, A; Nicken, P; Steinberg, P, 2012) |
| " In addition, we assessed a dose-response relationship." | 2.61 | Dietary Heterocyclic Amine Intake and Colorectal Adenoma Risk: A Systematic Review and Meta-analysis. ( Castaño, PR; Linseisen, J; Martínez Góngora, V; Matthes, KL; Rohrmann, S, 2019) |
| "During 7 years of follow-up, 2,719 colorectal cancer cases were ascertained from a cohort of 300,948 men and women." | 1.36 | A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association. ( Cross, AJ; Ferrucci, LM; Graubard, BI; Hollenbeck, AR; Park, Y; Risch, A; Schatzkin, A; Sinha, R; Ward, MH, 2010) |
| "A case-control study of colorectal cancer, consisting of 157 cases and 380 controls matched by sex, ethnicity, decade of age and county of residence was performed to explore the associations between environmental exposure, metabolic polymorphisms and cancer risk." | 1.31 | Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk. ( Ambrosone, CB; Coles, B; Kadlubar, FF; Lang, NP; Luke Ratnasinghe, D; MacLeod, S; Nowell, S; Sinha, R; Stotts, C, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (14.81) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 12 (44.44) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Dao, HV | 1 |
| Nguyen, TTM | 1 |
| Tran, HH | 1 |
| Dang, LT | 1 |
| Dinh, MT | 1 |
| Le, NT | 1 |
| Martínez Góngora, V | 1 |
| Matthes, KL | 1 |
| Castaño, PR | 1 |
| Linseisen, J | 2 |
| Rohrmann, S | 2 |
| Zhang, J | 1 |
| Lacroix, C | 1 |
| Wortmann, E | 1 |
| Ruscheweyh, HJ | 1 |
| Sunagawa, S | 1 |
| Sturla, SJ | 1 |
| Schwab, C | 1 |
| Miller, PE | 1 |
| Lazarus, P | 1 |
| Lesko, SM | 1 |
| Cross, AJ | 3 |
| Sinha, R | 5 |
| Laio, J | 1 |
| Zhu, J | 1 |
| Harper, G | 1 |
| Muscat, JE | 1 |
| Hartman, TJ | 1 |
| Jamin, EL | 1 |
| Riu, A | 1 |
| Douki, T | 1 |
| Debrauwer, L | 1 |
| Cravedi, JP | 1 |
| Zalko, D | 1 |
| Audebert, M | 1 |
| Budhathoki, S | 1 |
| Iwasaki, M | 1 |
| Yamaji, T | 1 |
| Sasazuki, S | 1 |
| Takachi, R | 1 |
| Sakamoto, H | 1 |
| Yoshida, T | 1 |
| Tsugane, S | 1 |
| Guo, J | 1 |
| Yonemori, K | 1 |
| Le Marchand, L | 2 |
| Turesky, RJ | 2 |
| Wang, R | 1 |
| Chen, YS | 1 |
| Dashwood, WM | 1 |
| Li, Q | 1 |
| Löhr, CV | 1 |
| Fischer, K | 1 |
| Ho, E | 1 |
| Williams, DE | 1 |
| Dashwood, RH | 1 |
| Hermann, S | 1 |
| Ferrucci, LM | 1 |
| Risch, A | 1 |
| Graubard, BI | 1 |
| Ward, MH | 1 |
| Park, Y | 1 |
| Hollenbeck, AR | 1 |
| Schatzkin, A | 1 |
| Nicken, P | 2 |
| Hamscher, G | 1 |
| Breves, G | 1 |
| Steinberg, P | 2 |
| Narushima, S | 1 |
| Sakata, T | 1 |
| Hioki, K | 1 |
| Itoh, T | 1 |
| Nomura, T | 1 |
| Itoh, K | 1 |
| Wang, H | 1 |
| Yamamoto, JF | 1 |
| Caberto, C | 1 |
| Saltzman, B | 1 |
| Decker, R | 1 |
| Vogt, TM | 1 |
| Yokochi, L | 1 |
| Chanock, S | 1 |
| Wilkens, LR | 1 |
| Brauer, N | 1 |
| Lampen, A | 1 |
| Nowell, S | 1 |
| Coles, B | 1 |
| MacLeod, S | 1 |
| Luke Ratnasinghe, D | 1 |
| Stotts, C | 1 |
| Kadlubar, FF | 1 |
| Ambrosone, CB | 1 |
| Lang, NP | 1 |
| Magagnotti, C | 1 |
| Pastorelli, R | 1 |
| Pozzi, S | 1 |
| Andreoni, B | 1 |
| Fanelli, R | 1 |
| Airoldi, L | 1 |
| Peters, U | 1 |
| Kulldorff, M | 1 |
| Weissfeld, JL | 1 |
| Pinsky, PF | 1 |
| Rothman, N | 3 |
| Hayes, RB | 1 |
| Lynch, AM | 1 |
| Murray, S | 1 |
| Gooderham, NJ | 1 |
| Boobis, AR | 1 |
| Thomson, B | 1 |
| Purewal, M | 1 |
| Velasco, M | 1 |
| Fretland, AJ | 1 |
| Hein, DW | 1 |
| Wargovich, MJ | 1 |
| Hagiwara, A | 2 |
| Miyashita, K | 1 |
| Nakanishi, T | 1 |
| Sano, M | 1 |
| Tamano, S | 2 |
| Kadota, T | 1 |
| Koda, T | 2 |
| Nakamura, M | 2 |
| Imaida, K | 2 |
| Ito, N | 2 |
| Shirai, T | 2 |
| Friesen, MD | 1 |
| Strickland, PT | 1 |
| Yoshino, H | 1 |
| Ichihara, T | 1 |
| Kawabe, M | 1 |
| Aoki, H | 1 |
| Cavin, C | 1 |
| Holzhaeuser, D | 1 |
| Scharf, G | 1 |
| Constable, A | 1 |
| Huber, WW | 1 |
| Schilter, B | 1 |
| O'Neill, I | 1 |
| Ohgaki, H | 1 |
| Ellul, A | 1 |
| Pan, JH | 1 |
| Cicalo, C | 1 |
| Le, B | 1 |
| Jeon, S | 1 |
| Kim, S | 1 |
| Hwang, KA | 1 |
| Kong, B | 1 |
| Lee, JH | 1 |
| Kim, JK | 1 |
3 reviews available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Colorectal Cancer
| Article | Year |
|---|---|
Dietary Heterocyclic Amine Intake and Colorectal Adenoma Risk: A Systematic Review and Meta-analysis.
Topics: Adenoma; Adult; Aged; Amines; Benzo(a)pyrene; Colorectal Neoplasms; Diet; Female; Heterocyclic Compo | 2019 |
Exposure to and activation of dietary heterocyclic amines in humans.
Topics: Animals; Biological Availability; Biotransformation; Carcinogens; Colorectal Neoplasms; Cooking; Cyt | 1995 |
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Ce | 2002 |
24 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Colorectal Cancer
| Article | Year |
|---|---|
A Case-Control Study of Meat Mutagens and Colorectal Cancers in Viet Nam.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Colorectal Neoplasms; Diet; Female; Follow-Up Studies | 2020 |
Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation.
Topics: Bacteria; Bacteroidetes; Biotransformation; Carcinogens; Colorectal Neoplasms; Diet; Feces; Firmicut | 2019 |
Meat-related compounds and colorectal cancer risk by anatomical subsite.
Topics: Aged; Animals; Benzo(a)pyrene; Case-Control Studies; Colonic Neoplasms; Colorectal Neoplasms; Cookin | 2013 |
Combined genotoxic effects of a polycyclic aromatic hydrocarbon (B(a)P) and an heterocyclic amine (PhIP) in relation to colorectal carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Cell Line; Chromatography, High Pressure Liquid; Colorectal Neoplasms; DNA | 2013 |
Dietary heterocyclic amine intake, NAT2 genetic polymorphism, and colorectal adenoma risk: the colorectal adenoma study in Tokyo.
Topics: Adenoma; Animals; Arylamine N-Acetyltransferase; Case-Control Studies; Colorectal Neoplasms; Diet; F | 2015 |
Method to Biomonitor the Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Dyed Hair by Ultra-Performance Liquid Chromatography-Orbitrap High Resolution Multistage Mass Spectrometry.
Topics: Adult; Carcinogens; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Cooking; Hair; Hair | 2015 |
Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; Catenins; Cell Movement; Cell Proliferati | 2017 |
Heterocyclic aromatic amine intake increases colorectal adenoma risk: findings from a prospective European cohort study.
Topics: Adenoma; Adult; Aged; Animals; Case-Control Studies; Cohort Studies; Colorectal Neoplasms; Cooking; | 2009 |
A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association.
Topics: Cohort Studies; Colorectal Neoplasms; Cooking; Diet; Female; Humans; Imidazoles; Male; Meat; Middle | 2010 |
Uptake of the colon carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different segments of the rat gastrointestinal tract: its implication in colorectal carcinogenesis.
Topics: Animals; ATP-Binding Cassette Transporters; Carcinogens; Colorectal Neoplasms; Imidazoles; Intestine | 2010 |
Inhibitory effect of yogurt on aberrant crypt foci formation in the rat colon and colorectal tumorigenesis in RasH2 mice.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colorectal Neoplasms; Disease Models, Animal; | 2010 |
Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.
Topics: Aged; Amines; Aryl Hydrocarbon Receptor Nuclear Translocator; Arylamine N-Acetyltransferase; Biotran | 2011 |
Influence of a fat-rich diet, folic acid supplementation and a human-relevant concentration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on the induction of preneoplastic lesions in the rat colon.
Topics: Aberrant Crypt Foci; Animals; Colon; Colorectal Neoplasms; Diet, High-Fat; Dietary Supplements; Foli | 2012 |
Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk.
Topics: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Arylsulfotransferase; Carcinogens; Ca | 2002 |
Genetic polymorphisms and modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in human lymphocytes.
Topics: Colorectal Neoplasms; Diet; DNA Adducts; Humans; Imidazoles; Lymphocytes; Phenotype; Polymerase Chai | 2003 |
Meat, meat cooking methods and preservation, and risk for colorectal adenoma.
Topics: Adenoma; Aged; Benzo(a)pyrene; Carcinogens; Colorectal Neoplasms; Cooking; Diet; Female; Food Preser | 2005 |
Heterocyclic amine levels in cooked meat and the implication for New Zealanders.
Topics: Animals; Carcinogens; Cattle; Chickens; Colorectal Neoplasms; Feeding Behavior; Fishes; Hot Temperat | 1999 |
Role of well-done, grilled red meat, heterocyclic amines (HCAs) in the etiology of human cancer.
Topics: Carcinogens; Colorectal Neoplasms; Humans; Imidazoles; Meat Products; Quinoxalines | 1999 |
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred rats.
Topics: Acetylation; Animals; Colorectal Neoplasms; Humans; Hydroxylation; Imidazoles; Intestinal Mucosa; Ma | 2000 |
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Administration, Oral; Anim | 2001 |
Concentration of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) in urine and alkali-hydrolyzed urine after consumption of charbroiled beef.
Topics: Adult; Alkalies; Animals; Carcinogens; Cattle; Colorectal Neoplasms; Cooking; Eating; Humans; Hydrol | 2001 |
Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Administration, Oral; Animals; Anthocyanins; Anticarcinogenic Agents | 2002 |
Entrapment by magnetic microcapsules of the protein pyrolysates IQ, PhIP and Glu-P-1, and alteration of IQ metabolite exposure within the rat gastrointestinal tract by risk-modulating components of the human diet.
Topics: Adsorption; Animals; Carcinogens; Colorectal Neoplasms; Diet; Digestive System; Humans; Imidazoles; | 1992 |
Colon Transcriptomics Reveals Sex-Dependent Metabolic Signatures in Response to 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Treatment in C57BL/6N Mice.
Topics: Aminopyridines; Animals; Colon; Colorectal Neoplasms; Female; Imidazoles; Male; Mice, Inbred C57BL; | 2020 |