2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Colitis in 5 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic colitis was induced by oral administration of dextran sulphate sodium (DSS) to Fischer 344 rats." | 1.43 | Impact of dextran sulphate sodium-induced colitis on the intestinal transport of the colon carcinogen PhIP. ( Breves, G; Giovannini, S; Kershaw, O; Nicken, P; Ostermann, AI; Schebb, NH; Steinberg, P; von Keutz, A; Willenberg, I, 2016) |
| "Considering the increased colon cancer risk associated with chronic colitis, we have therefore examined the effects of long-acting hGly(2)GLP-2, as well as of endogenous GLP-2 using the antagonist hGLP-2(3-33) in two novel models of inflammation-associated colon cancer: rats fed the carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet (HFD) for one or three cycles, and mice with chronic dextran sodium-sulfate (DSS)-induced colitis administered AOM." | 1.38 | Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer. ( Brubaker, PL; El-Zimaity, HM; Trivedi, S; Wiber, SC, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nicken, P | 1 |
| von Keutz, A | 1 |
| Willenberg, I | 1 |
| Ostermann, AI | 1 |
| Schebb, NH | 1 |
| Giovannini, S | 1 |
| Kershaw, O | 1 |
| Breves, G | 1 |
| Steinberg, P | 2 |
| Trivedi, S | 1 |
| Wiber, SC | 1 |
| El-Zimaity, HM | 1 |
| Brubaker, PL | 1 |
| Nakanishi, M | 1 |
| Tazawa, H | 1 |
| Tsuchiya, N | 1 |
| Sugimura, T | 1 |
| Tanaka, T | 1 |
| Nakagama, H | 1 |
| Kühnel, D | 1 |
| Taugner, F | 1 |
| Scholtka, B | 1 |
| Sliva, D | 1 |
| Loganathan, J | 1 |
| Jiang, J | 1 |
| Jedinak, A | 1 |
| Lamb, JG | 1 |
| Terry, C | 1 |
| Baldridge, LA | 1 |
| Adamec, J | 1 |
| Sandusky, GE | 1 |
| Dudhgaonkar, S | 1 |
5 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Colitis
| Article | Year |
|---|---|
Impact of dextran sulphate sodium-induced colitis on the intestinal transport of the colon carcinogen PhIP.
Topics: Animals; Carcinogens; Chromatography, Liquid; Chronic Disease; Colitis; Colonic Neoplasms; Dextran S | 2016 |
Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer.
Topics: Animals; Azoxymethane; beta Catenin; Blotting, Western; Carcinogens; Colitis; Colonic Neoplasms; Dex | 2012 |
Mouse strain differences in inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to PhIP-induced large bowel carcinogenesis.
Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Colitis; Colon; Colon | 2007 |
Inflammation does not precede or accompany the induction of preneoplastic lesions in the colon of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-fed rats.
Topics: Aminopyridines; Animals; Carcinogens; Colitis; Colon; Colonic Neoplasms; Hyperplasia; Imidazoles; Ma | 2009 |
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Apoptosis; Carcinogens; Cell Proliferation; Cell | 2012 |