Compounds > 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cocarcinogenesis

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Cocarcinogenesis in 12 studies

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.

Cocarcinogenesis: The combination of two or more different factors in the production of cancer.

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (41.67)18.2507
2000's7 (58.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mori, Y1
Koide, A1
Kobayashi, Y1
Furukawa, F1
Hirose, M1
Nishikawa, A1
Nakanishi, M1
Tazawa, H1
Tsuchiya, N1
Sugimura, T1
Tanaka, T1
Nakagama, H1
Ghoshal, A1
Preisegger, KH1
Takayama, S1
Thorgeirsson, SS1
Snyderwine, EG3
Rumney, CJ1
Rowland, IR1
Coutts, TM1
Randerath, K1
Reddy, R1
Shah, AB1
Ellul, A1
O'Neill, IK1
Ino, N1
Sugie, S1
Ohnishi, M1
Mori, H1
Kolar, C1
Lawson, T1
Davis, CD1
Schut, HA1
Roberts-Thomson, SJ2
Glaab, WE1
Kort, KL1
Skopek, TR1
Hagiwara, A2
Miyashita, K1
Nakanishi, T1
Sano, M1
Tamano, S2
Kadota, T1
Koda, T2
Nakamura, M2
Imaida, K2
Ito, N2
Shirai, T2
Zhang, S1
Lloyd, R1
Bowden, G1
Glickman, BW1
de Boer, JG1
Yoshino, H1
Ichihara, T1
Kawabe, M1
Aoki, H1

Other Studies

12 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cocarcinogenesis

ArticleYear
Effects of cigarette smoke and a heterocyclic amine, MeIQx on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver.
    Mutagenesis, 2003, Volume: 18, Issue:1

    Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Cocarc

2003
Mouse strain differences in inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to PhIP-induced large bowel carcinogenesis.
    Cancer science, 2007, Volume: 98, Issue:8

    Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Colitis; Colon; Colon

2007
Induction of mammary tumors in female Sprague-Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and effect of dietary fat.
    Carcinogenesis, 1994, Volume: 15, Issue:11

    Topics: Animals; Carcinogens; Cocarcinogenesis; Dietary Fats; Female; Imidazoles; Mammary Neoplasms, Experim

1994
Effects of risk-associated human dietary macrocomponents on processes related to carcinogenesis in human-flora-associated (HFA) rats.
    Carcinogenesis, 1993, Volume: 14, Issue:1

    Topics: Animals; Biotransformation; Cecum; Cocarcinogenesis; Cross-Linking Reagents; Dietary Fats; Dietary F

1993
Lack of inhibitory effect of benzyl isothiocyanate on 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats.
    The Journal of toxicological sciences, 1996, Volume: 21, Issue:3

    Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Cocarcinogenesis; Dietary Fats; Female;

1996
Mutagenicity of carcinogenic nitrosamines when activated by hamster and human pancreatic duct epithelial cells.
    Cancer letters, 1997, Aug-19, Volume: 117, Issue:2

    Topics: Adolescent; Adult; Animals; Biotransformation; Carcinogens; Cells, Cultured; Child; Cocarcinogenesis

1997
Proliferation, development and DNA adduct levels in the mammary gland of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a high fat diet.
    Carcinogenesis, 1998, Volume: 19, Issue:7

    Topics: Animals; Carcinogens; Cell Division; Cocarcinogenesis; Dietary Fats; DNA Adducts; Female; Imidazoles

1998
Specificity of mutations induced by the food-associated heterocyclic amine 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine in colon cancer cell lines defective in mismatch repair.
    Cancer research, 2000, Sep-01, Volume: 60, Issue:17

    Topics: Base Pair Mismatch; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; DNA Mutational Analysis; DNA R

2000
Characterization of peroxisome proliferator-activated receptor alpha in normal rat mammary gland and 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine-induced mammary gland tumors from rats fed high and low fat diets.
    Toxicology letters, 2000, Dec-20, Volume: 118, Issue:1-2

    Topics: Animals; Carcinogens; Cocarcinogenesis; Dietary Fats; Dose-Response Relationship, Drug; Female; Gene

2000
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.
    Cancer letters, 2001, Sep-28, Volume: 171, Issue:1

    Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Administration, Oral; Anim

2001
Msh2 DNA mismatch repair gene deficiency and the food-borne mutagen 2-amino-1-methy1-6-phenolimidazo [4,5-b] pyridine (PhIP) synergistically affect mutagenesis in mouse colon.
    Oncogene, 2001, Sep-20, Volume: 20, Issue:42

    Topics: Animals; Bacterial Proteins; Base Pair Mismatch; Cocarcinogenesis; Colonic Neoplasms; Diet; DNA Muta

2001
Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
    The Journal of toxicological sciences, 2002, Volume: 27, Issue:1

    Topics: 1,2-Dimethylhydrazine; Adenoma; Administration, Oral; Animals; Anthocyanins; Anticarcinogenic Agents

2002