2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Cell Transformation, Neoplastic in 17 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As for colon cancer models in rodents, Apc-disrupted mice, including ApcMin, have been one of the most widely utilized animal models to dissect the molecular events implicated in the development of intestinal tumors." | 2.43 | Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP. ( Nakagama, H; Nakanishi, M; Ochiai, M, 2005) |
| "Inflammation was seen as increased TNFα levels in ob/ob mice." | 1.42 | Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation. ( Hetland, RB; Ngo, HT; Nygaard, UC; Steffensen, IL, 2015) |
| "More than 85% breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens through a multistep and multiyear disease process." | 1.40 | Dipyridamole intervention of breast cell carcinogenesis. ( Choudhary, S; Sood, S; Wang, HC, 2014) |
| "More than 85% of breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens, such as those in the diet, through a multistep disease process progressing from non-cancerous to premalignant and malignant stages." | 1.38 | Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. ( Choudhary, S; Donnell, RL; Sood, S; Wang, HC, 2012) |
| "To develop a relevant mouse model for prostate cancer prevention research, we administered a dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), to CYP1A-humanized mice." | 1.38 | Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice. ( Bosland, MC; Cheung, C; Li, G; Liu, AB; Reuhl, KR; Wang, H; Yang, CS, 2012) |
| "An increased risk of breast cancer has been observed in women who consume "very well-done" meats." | 1.31 | Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the milk of healthy women. ( DeBruin, LS; Josephy, PD; Martos, PA, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Canene-Adams, K | 2 |
| Sfanos, KS | 2 |
| Liang, CT | 1 |
| Yegnasubramanian, S | 1 |
| Nelson, WG | 2 |
| Brayton, C | 1 |
| De Marzo, AM | 2 |
| Pluchino, LA | 1 |
| Liu, AK | 1 |
| Wang, HC | 3 |
| Hempel, H | 1 |
| Yu, SH | 1 |
| Simons, BW | 1 |
| Schaeffer, AJ | 1 |
| Schaeffer, EM | 1 |
| Ngo, HT | 1 |
| Hetland, RB | 1 |
| Nygaard, UC | 1 |
| Steffensen, IL | 2 |
| Choudhary, S | 2 |
| Sood, S | 2 |
| Donnell, RL | 1 |
| Li, G | 1 |
| Wang, H | 1 |
| Liu, AB | 1 |
| Cheung, C | 1 |
| Reuhl, KR | 1 |
| Bosland, MC | 1 |
| Yang, CS | 1 |
| Naito, A | 1 |
| Suzuki, A | 1 |
| Ueda, S | 1 |
| Nomoto, H | 1 |
| Toriyama-Baba, H | 1 |
| Asamoto, M | 1 |
| Tsuda, H | 1 |
| Nohmi, T | 1 |
| Masumura, K | 1 |
| Nakagama, H | 1 |
| Nakanishi, M | 1 |
| Ochiai, M | 1 |
| Alexander, J | 1 |
| Sugimura, T | 1 |
| Pfau, W | 1 |
| Martin, FL | 1 |
| Cole, KJ | 1 |
| Venitt, S | 1 |
| Phillips, DH | 1 |
| Grover, PL | 1 |
| Marquardt, H | 1 |
| He, YH | 1 |
| Friesen, MD | 1 |
| Ruch, RJ | 1 |
| Schut, HA | 1 |
| DeBruin, LS | 1 |
| Martos, PA | 1 |
| Josephy, PD | 2 |
| McDiarmid, HM | 1 |
| Douglas, GR | 1 |
| Coomber, BL | 1 |
| Sliva, D | 1 |
| Loganathan, J | 1 |
| Jiang, J | 1 |
| Jedinak, A | 1 |
| Lamb, JG | 1 |
| Terry, C | 1 |
| Baldridge, LA | 1 |
| Adamec, J | 1 |
| Sandusky, GE | 1 |
| Dudhgaonkar, S | 1 |
2 reviews available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Gpt delta transgenic mouse: a novel approach for molecular dissection of deletion mutations in vivo.
Topics: Animals; Bone Marrow; Cell Transformation, Neoplastic; Colon; DNA Damage; DNA-Activated Protein Kina | 2004 |
Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Colonic Neoplasms; Dise | 2005 |
15 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Dietary chemoprevention of PhIP induced carcinogenesis in male Fischer 344 rats with tomato and broccoli.
Topics: Animal Feed; Animals; Body Weight; Brassica; Carcinogens; Cell Transformation, Neoplastic; Chemoprev | 2013 |
Reactive oxygen species-mediated breast cell carcinogenesis enhanced by multiple carcinogens and intervened by dietary ergosterol and mimosine.
Topics: Aldehyde Dehydrogenase; Benzopyrenes; Carcinogens; Cell Line; Cell Movement; Cell Proliferation; Cel | 2015 |
Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP)-Induced Cancer at Multiple Sites.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Escherichia coli; Escherichia coli Infections | 2015 |
Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation.
Topics: Animals; Body Weight; Carcinogenesis; Cell Transformation, Neoplastic; Female; Imidazoles; Inflammat | 2015 |
Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Base Sequence; Breast Neoplasms; Carcinogens; Catechin; Cell Line, Tumor; Cell Transformation, Neopl | 2012 |
Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.
Topics: Animals; Cadherins; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 CYP1A2; Diet, Hig | 2012 |
Dipyridamole intervention of breast cell carcinogenesis.
Topics: Apoptosis; Benzo(a)pyrene; Blotting, Western; Breast; Breast Neoplasms; Carcinogens; Cell Adhesion; | 2014 |
Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats.
Topics: Animals; Animals, Genetically Modified; Carcinogens; Cell Transformation, Neoplastic; DNA, Neoplasm; | 2004 |
Impact of genetic background on spontaneous or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumorigenesis in Min/+ mice.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Genes, APC; Imidazoles; Intestinal Ne | 2006 |
An overview of cancer prevention.
Topics: beta Carotene; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Environmental Exposure | 1996 |
Heterocyclic aromatic amines induce DNA strand breaks and cell transformation.
Topics: Animals; Biotransformation; Carbolines; Carcinogens, Environmental; Cell Transformation, Neoplastic; | 1999 |
Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochrome P450 in female F344 rats.
Topics: Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; D | 2000 |
Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the milk of healthy women.
Topics: Adult; Breast Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Chromatography, Liquid; Cooki | 2001 |
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mutagenesis in cultured Big Blue rat mammary epithelial and fibroblast cells.
Topics: Animals; Animals, Genetically Modified; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; | 2002 |
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Apoptosis; Carcinogens; Cell Proliferation; Cell | 2012 |