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2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cell Transformation, Neoplastic

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Cell Transformation, Neoplastic in 17 studies

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.

Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Research Excerpts

ExcerptRelevanceReference
"As for colon cancer models in rodents, Apc-disrupted mice, including ApcMin, have been one of the most widely utilized animal models to dissect the molecular events implicated in the development of intestinal tumors."2.43Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP. ( Nakagama, H; Nakanishi, M; Ochiai, M, 2005)
"Inflammation was seen as increased TNFα levels in ob/ob mice."1.42Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation. ( Hetland, RB; Ngo, HT; Nygaard, UC; Steffensen, IL, 2015)
"More than 85% breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens through a multistep and multiyear disease process."1.40Dipyridamole intervention of breast cell carcinogenesis. ( Choudhary, S; Sood, S; Wang, HC, 2014)
"More than 85% of breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens, such as those in the diet, through a multistep disease process progressing from non-cancerous to premalignant and malignant stages."1.38Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. ( Choudhary, S; Donnell, RL; Sood, S; Wang, HC, 2012)
"To develop a relevant mouse model for prostate cancer prevention research, we administered a dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), to CYP1A-humanized mice."1.38Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice. ( Bosland, MC; Cheung, C; Li, G; Liu, AB; Reuhl, KR; Wang, H; Yang, CS, 2012)
"An increased risk of breast cancer has been observed in women who consume "very well-done" meats."1.31Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the milk of healthy women. ( DeBruin, LS; Josephy, PD; Martos, PA, 2001)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (11.76)18.2507
2000's7 (41.18)29.6817
2010's8 (47.06)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Canene-Adams, K2
Sfanos, KS2
Liang, CT1
Yegnasubramanian, S1
Nelson, WG2
Brayton, C1
De Marzo, AM2
Pluchino, LA1
Liu, AK1
Wang, HC3
Hempel, H1
Yu, SH1
Simons, BW1
Schaeffer, AJ1
Schaeffer, EM1
Ngo, HT1
Hetland, RB1
Nygaard, UC1
Steffensen, IL2
Choudhary, S2
Sood, S2
Donnell, RL1
Li, G1
Wang, H1
Liu, AB1
Cheung, C1
Reuhl, KR1
Bosland, MC1
Yang, CS1
Naito, A1
Suzuki, A1
Ueda, S1
Nomoto, H1
Toriyama-Baba, H1
Asamoto, M1
Tsuda, H1
Nohmi, T1
Masumura, K1
Nakagama, H1
Nakanishi, M1
Ochiai, M1
Alexander, J1
Sugimura, T1
Pfau, W1
Martin, FL1
Cole, KJ1
Venitt, S1
Phillips, DH1
Grover, PL1
Marquardt, H1
He, YH1
Friesen, MD1
Ruch, RJ1
Schut, HA1
DeBruin, LS1
Martos, PA1
Josephy, PD2
McDiarmid, HM1
Douglas, GR1
Coomber, BL1
Sliva, D1
Loganathan, J1
Jiang, J1
Jedinak, A1
Lamb, JG1
Terry, C1
Baldridge, LA1
Adamec, J1
Sandusky, GE1
Dudhgaonkar, S1

Reviews

2 reviews available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cell Transformation, Neoplastic

ArticleYear
Gpt delta transgenic mouse: a novel approach for molecular dissection of deletion mutations in vivo.
    Advances in biophysics, 2004, Volume: 38

    Topics: Animals; Bone Marrow; Cell Transformation, Neoplastic; Colon; DNA Damage; DNA-Activated Protein Kina

2004
Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP.
    Cancer science, 2005, Volume: 96, Issue:10

    Topics: Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Colonic Neoplasms; Dise

2005

Other Studies

15 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cell Transformation, Neoplastic

ArticleYear
Dietary chemoprevention of PhIP induced carcinogenesis in male Fischer 344 rats with tomato and broccoli.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Animal Feed; Animals; Body Weight; Brassica; Carcinogens; Cell Transformation, Neoplastic; Chemoprev

2013
Reactive oxygen species-mediated breast cell carcinogenesis enhanced by multiple carcinogens and intervened by dietary ergosterol and mimosine.
    Free radical biology & medicine, 2015, Volume: 80

    Topics: Aldehyde Dehydrogenase; Benzopyrenes; Carcinogens; Cell Line; Cell Movement; Cell Proliferation; Cel

2015
Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP)-Induced Cancer at Multiple Sites.
    Cancer prevention research (Philadelphia, Pa.), 2015, Volume: 8, Issue:8

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Escherichia coli; Escherichia coli Infections

2015
Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation.
    Journal of obesity, 2015, Volume: 2015

    Topics: Animals; Body Weight; Carcinogenesis; Cell Transformation, Neoplastic; Female; Imidazoles; Inflammat

2015
Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
    Carcinogenesis, 2012, Volume: 33, Issue:4

    Topics: Base Sequence; Breast Neoplasms; Carcinogens; Catechin; Cell Line, Tumor; Cell Transformation, Neopl

2012
Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.
    Cancer prevention research (Philadelphia, Pa.), 2012, Volume: 5, Issue:7

    Topics: Animals; Cadherins; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 CYP1A2; Diet, Hig

2012
Dipyridamole intervention of breast cell carcinogenesis.
    Molecular carcinogenesis, 2014, Volume: 53, Issue:3

    Topics: Apoptosis; Benzo(a)pyrene; Blotting, Western; Breast; Breast Neoplasms; Carcinogens; Cell Adhesion;

2014
Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats.
    Cancer science, 2004, Volume: 95, Issue:5

    Topics: Animals; Animals, Genetically Modified; Carcinogens; Cell Transformation, Neoplastic; DNA, Neoplasm;

2004
Impact of genetic background on spontaneous or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumorigenesis in Min/+ mice.
    Cancer letters, 2006, Aug-28, Volume: 240, Issue:2

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Genes, APC; Imidazoles; Intestinal Ne

2006
An overview of cancer prevention.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 1996, Volume: 5 Suppl 2

    Topics: beta Carotene; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Environmental Exposure

1996
Heterocyclic aromatic amines induce DNA strand breaks and cell transformation.
    Carcinogenesis, 1999, Volume: 20, Issue:4

    Topics: Animals; Biotransformation; Carbolines; Carcinogens, Environmental; Cell Transformation, Neoplastic;

1999
Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochrome P450 in female F344 rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2000, Volume: 38, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; D

2000
Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the milk of healthy women.
    Chemical research in toxicology, 2001, Volume: 14, Issue:11

    Topics: Adult; Breast Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Chromatography, Liquid; Cooki

2001
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mutagenesis in cultured Big Blue rat mammary epithelial and fibroblast cells.
    Environmental and molecular mutagenesis, 2002, Volume: 39, Issue:2-3

    Topics: Animals; Animals, Genetically Modified; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured;

2002
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Apoptosis; Carcinogens; Cell Proliferation; Cell

2012