2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Carcinoma, Renal Cell in 3 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These associations may be modified by genetic susceptibility to RCC." | 1.43 | Gene-environment interaction of genome-wide association study-identified susceptibility loci and meat-cooking mutagens in the etiology of renal cell carcinoma. ( Daniel, CR; Karam, JA; Matin, SF; Melkonian, SC; Tannir, NM; Wood, CG; Wu, X; Ye, Y, 2016) |
| "The evidence for meat intake and renal cell carcinoma (RCC) risk is inconsistent." | 1.38 | Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma. ( Chow, WH; Cross, AJ; Daniel, CR; Graubard, BI; Hollenbeck, AR; Park, Y; Rothman, N; Sinha, R; Ward, MH, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yeh, IJ | 1 |
| Chen, SC | 1 |
| Yen, MC | 1 |
| Wu, YH | 1 |
| Hung, CH | 1 |
| Kuo, PL | 1 |
| Melkonian, SC | 1 |
| Daniel, CR | 2 |
| Ye, Y | 1 |
| Tannir, NM | 1 |
| Karam, JA | 1 |
| Matin, SF | 1 |
| Wood, CG | 1 |
| Wu, X | 1 |
| Cross, AJ | 1 |
| Graubard, BI | 1 |
| Park, Y | 1 |
| Ward, MH | 1 |
| Rothman, N | 1 |
| Hollenbeck, AR | 1 |
| Chow, WH | 1 |
| Sinha, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NCI-AARP Diet and Health Study[NCT00340015] | 566,401 participants (Actual) | Observational | 1995-10-24 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Carcinoma, Renal Cell
| Article | Year |
|---|---|
6-Shogaol Suppresses 2-Amino-1-Methyl-6-Phenylimidazo [4,5-b] Pyridine (PhIP)-Induced Human 786-O Renal Cell Carcinoma Osteoclastogenic Activity and Metastatic Potential.
Topics: Carcinoma, Renal Cell; Catechols; Cell Line, Tumor; Humans; Imidazoles; Kidney Neoplasms; Neoplasm M | 2019 |
Gene-environment interaction of genome-wide association study-identified susceptibility loci and meat-cooking mutagens in the etiology of renal cell carcinoma.
Topics: Carcinoma, Renal Cell; Case-Control Studies; Disease Susceptibility; Female; Gene-Environment Intera | 2016 |
Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma.
Topics: Benzo(a)pyrene; Carcinoma, Renal Cell; Cooking; Diet; Female; Humans; Imidazoles; Incidence; Male; M | 2012 |