2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Carcinoma, Hepatocellular in 5 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cultures of primary hepatocytes and hepatoma cell line HepG2 are frequently used in in vitro models for human biotransformation studies." | 1.32 | Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. ( Bader, A; Stahl, F; Wilkening, S, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haza, AI | 1 |
| Morales, P | 1 |
| Wilkening, S | 1 |
| Stahl, F | 1 |
| Bader, A | 1 |
| Knasmüller, S | 3 |
| Friesen, MD | 1 |
| Holme, JA | 1 |
| Alexander, J | 1 |
| Sanyal, R | 3 |
| Kassie, F | 1 |
| Bartsch, H | 1 |
| Darroudi, F | 2 |
| Parzefall, W | 2 |
| Nagao, M | 1 |
| Schwab, CE | 1 |
| Land, SJ | 1 |
| Wang, CY | 1 |
| Kundi, M | 1 |
5 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Effects of (+)-catechin and (-)-epicatechin on heterocyclic amines-induced oxidative DNA damage.
Topics: Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Comet Assay; DNA Damage; Dose-Response Relati | 2011 |
Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties.
Topics: 7-Alkoxycoumarin O-Dealkylase; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line, Tumor; Comet As | 2003 |
Effects of phenethyl isothiocyanate on metabolism and on genotoxicity of dimethylnitrosamine and 2-amino-1-methyl-6-phenylimidazo[4, 5-beta]pyridine (PhIP).
Topics: Animals; Antimutagenic Agents; Biotransformation; Carcinoma, Hepatocellular; Dimethylnitrosamine; DN | 1996 |
Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens.
Topics: Acrolein; Amines; Antimutagenic Agents; Benzaldehydes; Caffeine; Carbolines; Carcinoma, Hepatocellul | 1997 |
Genotoxic effects of heterocyclic aromatic amines in human derived hepatoma (HepG2) cells.
Topics: Amines; Animals; Arylamine N-Acetyltransferase; Carbolines; Carcinogens; Carcinoma, Hepatocellular; | 1999 |