2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Carcinogenesis in 9 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Obesity is associated with an increased risk of cancer." | 1.43 | Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc. ( Chi, E; Kuo, Y; Liu, A; Wang, H; Yang, CS; Yang, X; Zhang, L, 2016) |
| "Inflammation was seen as increased TNFα levels in ob/ob mice." | 1.42 | Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation. ( Hetland, RB; Ngo, HT; Nygaard, UC; Steffensen, IL, 2015) |
| "We evaluated mammary carcinogenesis initiated by combined exposure to various doses of radiation and chemical carcinogens." | 1.40 | Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis. ( Doi, K; Imai, T; Imaoka, T; Ishikawa, K; Nishimura, M; Shimada, Y; Tani, S; Ushijima, T; Yamashita, S, 2014) |
| "Obesity is highly associated with colon cancer development." | 1.40 | AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats. ( Fukuda, H; Hippo, Y; Igarashi, M; Nakagama, H; Ochiai, M, 2014) |
| "Initiation of carcinogenesis was measured by transient endpoints induced in a single exposure, while progression of carcinogenesis was measured by acquisition of constitutive endpoints in cumulative exposures." | 1.40 | Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties. ( Pluchino, LA; Wang, HC, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| El-Sisi, AE | 1 |
| Sokar, SS | 1 |
| El-Sayad, ME | 1 |
| Moussa, EA | 1 |
| Salim, EI | 1 |
| Imaoka, T | 1 |
| Nishimura, M | 1 |
| Doi, K | 1 |
| Tani, S | 1 |
| Ishikawa, K | 1 |
| Yamashita, S | 1 |
| Ushijima, T | 1 |
| Imai, T | 1 |
| Shimada, Y | 1 |
| Igarashi, M | 1 |
| Hippo, Y | 1 |
| Ochiai, M | 2 |
| Fukuda, H | 1 |
| Nakagama, H | 2 |
| Wang, H | 3 |
| Zhou, H | 1 |
| Liu, A | 3 |
| Guo, X | 1 |
| Yang, CS | 3 |
| Pluchino, LA | 1 |
| Wang, HC | 1 |
| Ngo, HT | 1 |
| Hetland, RB | 1 |
| Nygaard, UC | 1 |
| Steffensen, IL | 1 |
| Chen, JX | 1 |
| Lee, MJ | 1 |
| Yu, S | 1 |
| Chi, E | 2 |
| Reuhl, K | 1 |
| Suh, N | 1 |
| Kuo, Y | 1 |
| Yang, X | 1 |
| Zhang, L | 1 |
| Okudaira, N | 1 |
| Okamura, T | 1 |
| Tamura, M | 1 |
| Iijma, K | 1 |
| Goto, M | 1 |
| Matsunaga, A | 1 |
| Kano, S | 1 |
| Fujii-Kuriyama, Y | 1 |
| Ishizaka, Y | 1 |
9 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Carcinogenesis
| Article | Year |
|---|---|
Anticancer effect of metformin against 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine-induced rat mammary carcinogenesis is through AMPK pathway and modulation of oxidative stress markers.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Carcinogenesis; Carcinogens; Choleste | 2019 |
Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis.
Topics: Animals; Carcinogenesis; Carcinogens; Female; Imidazoles; Incidence; Mammary Neoplasms, Experimental | 2014 |
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Carcinogenesis; Carcinogens; Cell Line; Colon; Colonic Neop | 2014 |
Genetic analysis of colon tumors induced by a dietary carcinogen PhIP in CYP1A humanized mice: Identification of mutation of β-catenin/Ctnnb1 as the driver gene for the carcinogenesis.
Topics: Animals; beta Catenin; Carcinogenesis; Carcinogens; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Diet | 2015 |
Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties.
Topics: Benzo(a)pyrene; Breast Neoplasms; Carcinogenesis; Carcinogens; DNA Damage; Drug Synergism; Epithelia | 2014 |
Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation.
Topics: Animals; Body Weight; Carcinogenesis; Cell Transformation, Neoplastic; Female; Imidazoles; Inflammat | 2015 |
δ- and γ-tocopherols inhibit phIP/DSS-induced colon carcinogenesis by protection against early cellular and DNA damages.
Topics: Animals; Anticarcinogenic Agents; Carcinogenesis; Colon; Colonic Neoplasms; Cytochrome P-450 CYP1A1; | 2017 |
Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc.
Topics: Adenomatous Polyposis Coli Protein; Animals; beta Catenin; Carcinogenesis; Cytochrome P-450 CYP1A1; | 2016 |
Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Female; Food; Genomic Instability; Humans; I | 2013 |