2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Cancer of Prostate in 29 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response modelling of the data for these three tumour types gives BMDL10 values of 0." | 2.46 | Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine). ( Carthew, P; DiNovi, M; Setzer, RW, 2010) |
| " Induction of invasive prostate carcinomas in the rat frequently requires long-term administration of a pharmacological dose of testosterone with or without application of a chemical carcinogen." | 2.41 | Experimental prostate carcinogenesis - rodent models. ( Cui, L; Futakuchi, M; Imaida, K; Kato, K; Shirai, T; Takahashi, S; Tamano, S, 2000) |
| "Until 2010, 2,770 prostate cancer cases were observed among 26,030 participants." | 1.42 | Intake of Meat Mutagens and Risk of Prostate Cancer in a Cohort of U.S. Health Professionals. ( Giovannucci, EL; Nimptsch, K; Platz, EA; Rohrmann, S; Sinha, R; Willett, WC; Wu, K, 2015) |
| "To develop a relevant mouse model for prostate cancer prevention research, we administered a dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), to CYP1A-humanized mice." | 1.38 | Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice. ( Bosland, MC; Cheung, C; Li, G; Liu, AB; Reuhl, KR; Wang, H; Yang, CS, 2012) |
| "African-American men die from prostate cancer (PC) nearly twice as often as white US men and consume about twice as much of the predominant US dietary heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a genotoxic rat-prostate carcinogen found primarily in well-cooked chicken and beef." | 1.34 | Highly elevated PSA and dietary PhIP intake in a prospective clinic-based study among African Americans. ( Bogen, KT; Chan, JM; Holly, EA; Keating, GA; Nelson, DO; Paine, LJ; Simms, EL, 2007) |
| " These featured dietary administration of PhIP at different dose levels and for different durations, and included intragastric dosing for a short period, or continuous dietary administration after initiation with other carcinogen, namely 3,2'-dimethyl-4-aminobiphenyl (DMAB) or 1,2-dimethylhydrazine (DMH)." | 1.31 | Organ differences in the enhancing potential of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on carcinogenicity in the prostate, colon and pancreas. ( Asamoto, M; Futakuchi, M; Imaida, K; Kato, K; Shirai, T; Suzuki, S; Takahashi, S, 2002) |
| " The current experimental data demonstrate that only a 20-week period of PhIP treatment is sufficient for induction of ventral carcinomas and that long-term pharmacological dosing with testosterone propionate which applied through a Silastic tube embedded in the subcutis after PhIP treatment can induce invasive carcinomas in the anterior prostate and seminal vesicles." | 1.30 | Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate. ( Asamoto, M; Cui, L; Futakuchi, M; Ito, N; Kato, K; Shirai, T; Takahashi, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 19 (65.52) | 29.6817 |
| 2010's | 8 (27.59) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellamri, M | 1 |
| Xiao, S | 1 |
| Murugan, P | 1 |
| Weight, CJ | 1 |
| Turesky, RJ | 1 |
| Li, RJ | 1 |
| Tian, JJ | 1 |
| Li, WQ | 1 |
| Cheng, FQ | 1 |
| Gao, GS | 1 |
| Sfanos, KS | 1 |
| Canene-Adams, K | 1 |
| Hempel, H | 1 |
| Yu, SH | 1 |
| Simons, BW | 1 |
| Schaeffer, AJ | 1 |
| Schaeffer, EM | 1 |
| Nelson, WG | 3 |
| De Marzo, AM | 3 |
| Rohrmann, S | 1 |
| Nimptsch, K | 1 |
| Sinha, R | 2 |
| Willett, WC | 1 |
| Giovannucci, EL | 1 |
| Platz, EA | 1 |
| Wu, K | 1 |
| Chen, JX | 1 |
| Li, G | 2 |
| Wang, H | 2 |
| Liu, A | 1 |
| Lee, MJ | 1 |
| Reuhl, K | 1 |
| Suh, N | 1 |
| Bosland, MC | 2 |
| Yang, CS | 2 |
| Boyiri, T | 1 |
| Somiari, RI | 1 |
| Russell, S | 1 |
| Aliaga, C | 1 |
| El-Bayoumy, K | 1 |
| Carthew, P | 1 |
| DiNovi, M | 1 |
| Setzer, RW | 1 |
| Tang, MX | 1 |
| Ogawa, K | 4 |
| Asamoto, M | 9 |
| Chewonarin, T | 1 |
| Suzuki, S | 4 |
| Tanaka, T | 1 |
| Shirai, T | 13 |
| Liu, AB | 1 |
| Cheung, C | 1 |
| Reuhl, KR | 1 |
| Kato, K | 5 |
| Futakuchi, M | 6 |
| Takahashi, S | 9 |
| Imaida, K | 7 |
| Cho, YM | 3 |
| Inaguma, S | 2 |
| Hokaiwado, N | 2 |
| Ohnishi, H | 1 |
| Hikosaka, A | 1 |
| Kuzutani, K | 1 |
| Kohri, K | 1 |
| Ikeda, Y | 2 |
| Tang, M | 1 |
| Cross, AJ | 1 |
| Peters, U | 1 |
| Kirsh, VA | 1 |
| Andriole, GL | 1 |
| Reding, D | 1 |
| Hayes, RB | 1 |
| El-Zein, R | 1 |
| Etzel, CJ | 1 |
| Lopez, MS | 1 |
| Gu, Y | 1 |
| Spitz, MR | 1 |
| Strom, SS | 1 |
| Borowsky, AD | 1 |
| Dingley, KH | 1 |
| Ubick, E | 1 |
| Turteltaub, KW | 1 |
| Cardiff, RD | 1 |
| Devere-White, R | 1 |
| Bogen, KT | 1 |
| Keating, GA | 1 |
| Chan, JM | 1 |
| Paine, LJ | 1 |
| Simms, EL | 1 |
| Nelson, DO | 1 |
| Holly, EA | 1 |
| Nakai, Y | 1 |
| Creton, SK | 1 |
| Zhu, H | 1 |
| Gooderham, NJ | 1 |
| Sano, M | 3 |
| Tamano, S | 5 |
| Hirose, M | 2 |
| Hasegawa, R | 1 |
| Matsumoto, K | 1 |
| Wakabayashi, K | 1 |
| Sugimura, T | 1 |
| Ito, N | 3 |
| Cui, L | 2 |
| Purewal, M | 1 |
| Fretland, AJ | 1 |
| Schut, HA | 1 |
| Hein, DW | 1 |
| Wargovich, MJ | 1 |
| Nelson, CP | 1 |
| Kidd, LC | 1 |
| Sauvageot, J | 1 |
| Isaacs, WB | 1 |
| Groopman, JD | 1 |
| Kensler, TW | 1 |
| Nir, Z | 1 |
| Murakoshi, M | 1 |
| Nishino, H | 1 |
| Hagiwara, A | 1 |
| Miyashita, K | 1 |
| Nakanishi, T | 1 |
| Kadota, T | 1 |
| Koda, T | 1 |
| Nakamura, M | 1 |
| Miki, T | 1 |
2 reviews available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cancer of Prostate
| Article | Year |
|---|---|
Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine).
Topics: Animals; Breast Neoplasms; Carcinogens; Colonic Neoplasms; Cooking; Data Interpretation, Statistical | 2010 |
Experimental prostate carcinogenesis - rodent models.
Topics: Aminobiphenyl Compounds; Animals; Carcinogens; Disease Models, Animal; Imidazoles; Male; Methylnitro | 2000 |
1 trial available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cancer of Prostate
| Article | Year |
|---|---|
A prospective study of meat and meat mutagens and prostate cancer risk.
Topics: Aged; Benzo(a)pyrene; Cooking; Diet; Humans; Imidazoles; Male; Meat; Middle Aged; Mutagens; Prospect | 2005 |
26 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cancer of Prostate
| Article | Year |
|---|---|
Metabolic Activation of the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine in Human Prostate.
Topics: Activation, Metabolic; Carcinogens; Cell Line, Tumor; Cell Survival; Cooking; Cytosol; DNA Adducts; | 2018 |
Effect of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine on oxidative stress and gene expression of c-fos, c-jun, p16 and Rb in rat colons and protective role of seabuckthorn seed oil.
Topics: Animals; Colon; Cyclin-Dependent Kinase Inhibitor p16; Gene Expression; Hippophae; Humans; Imidazole | 2014 |
Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP)-Induced Cancer at Multiple Sites.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Escherichia coli; Escherichia coli Infections | 2015 |
Intake of Meat Mutagens and Risk of Prostate Cancer in a Cohort of U.S. Health Professionals.
Topics: Adult; Aged; Benzimidazoles; Cooking; Feeding Behavior; Follow-Up Studies; Health Personnel; Humans; | 2015 |
Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Cyclooxygenase 2; Cytochrome P-450 CY | 2016 |
Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination.
Topics: Animals; Blotting, Western; Carcinogens; Chromatography, Liquid; Dihydrotestosterone; Electrophoresi | 2009 |
Effects of nobiletin on PhIP-induced prostate and colon carcinogenesis in F344 rats.
Topics: Aberrant Crypt Foci; Adenocarcinoma; Animals; Carcinogens; Chemoprevention; Colonic Neoplasms; Flavo | 2011 |
Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.
Topics: Animals; Cadherins; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 CYP1A2; Diet, Hig | 2012 |
Organ differences in the enhancing potential of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on carcinogenicity in the prostate, colon and pancreas.
Topics: 1,2-Dimethylhydrazine; Aminobiphenyl Compounds; Animals; Carcinogens; Colon; Colonic Neoplasms; DNA | 2002 |
Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: lack of influence of carcinogen or testosterone treatment.
Topics: Adenocarcinoma; Age Factors; Aminobiphenyl Compounds; Androgen Antagonists; Androgen-Binding Protein | 2003 |
High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) prostate carcinogenesis.
Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Disease Progression; Disease S | 2003 |
Inhibitory effects of soy isoflavones on rat prostate carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Topics: Animals; Antineoplastic Agents; Body Weight; Carcinogens; Colonic Neoplasms; Imidazoles; Isoflavones | 2004 |
Equivocal impact of transplacental and lactational exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, on prostate and colon lesion development in F344 rats.
Topics: Animals; Carcinogens; Colonic Diseases; Colonic Neoplasms; Female; Imidazoles; Immunohistochemistry; | 2005 |
Human sensitivity to PhIP: a novel marker for prostate cancer risk.
Topics: Adult; Aged; Case-Control Studies; Cells, Cultured; Chromosome Aberrations; Chromosome Breakage; Dos | 2006 |
Inflammation and atrophy precede prostatic neoplasia in a PhIP-induced rat model.
Topics: Animals; Atrophy; Carcinogens; Cell Proliferation; Disease Models, Animal; Glutathione Transferase; | 2006 |
Highly elevated PSA and dietary PhIP intake in a prospective clinic-based study among African Americans.
Topics: Adult; Aged; Black or African American; Carcinogens; Diet; Humans; Imidazoles; Male; Meat; Middle Ag | 2007 |
The dietary charred meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine acts as both a tumor initiator and promoter in the rat ventral prostate.
Topics: Animals; Animals, Genetically Modified; Carcinogens; Cell Growth Processes; Imidazoles; Immunophenot | 2007 |
The cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates the extracellular signal regulated kinase mitogen-activated protein kinase pathway.
Topics: Adenocarcinoma; Breast; Carcinogens; Cell Movement; Cell Proliferation; Cells, Cultured; Chemotaxis; | 2007 |
The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.
Topics: Animals; Carcinogens; Imidazoles; Male; Neoplasms, Experimental; Prostate; Prostatic Hyperplasia; Pr | 1997 |
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate.
Topics: Animals; Carcinogens; Drug Synergism; Imidazoles; Male; Neoplasm Invasiveness; Prostatic Neoplasms; | 1999 |
Association between acetylator genotype and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) DNA adduct formation in colon and prostate of inbred Fischer 344 and Wistar Kyoto rats.
Topics: Animals; Carcinogens; Colon; Colonic Neoplasms; DNA Adducts; Genetic Predisposition to Disease; Imid | 2000 |
Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1.
Topics: Adenocarcinoma; Aged; Biotransformation; Carcinogens; Cytosol; DNA; DNA Adducts; Glutathione S-Trans | 2001 |
Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.
Topics: Aminobiphenyl Compounds; Animals; Anticarcinogenic Agents; Carcinogens; Carotenoids; Curcumin; Imida | 2001 |
Organ dependent enhancement of rat 3,2'-dimethyl-4-aminobiphenyl (DMAB) carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): positive effects on the intestine but not the prostate.
Topics: Aminobiphenyl Compounds; Animals; Carcinogens; DNA Adducts; Drug Synergism; Imidazoles; Immunohistoc | 2001 |
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Administration, Oral; Anim | 2001 |
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animal Feed; Animals; Carcinogens; Colonic Neoplasms; DNA Add | 2002 |