2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
28 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cancer of Intestines
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Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation.Journal of obesity, 2015, Volume: 2015Topics: Animals; Body Weight; Carcinogenesis; Cell Transformation, Neoplastic; Female; Imidazoles; Inflammat | 2015 |
Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc.Carcinogenesis, 2016, Volume: 37, Issue:7
Topics: Adenomatous Polyposis Coli Protein; Animals; beta Catenin; Carcinogenesis; Cytochrome P-450 CYP1A1; | 2016 |
Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases.Molecular carcinogenesis, 2012, Volume: 51, Issue:12
Topics: Animals; Carcinogens; Food Handling; Furaldehyde; Humans; Imidazoles; Intestinal Neoplasms; Mice; Mi | 2012 |
Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).Mutation research, 2002, Sep-30, Volume: 506-507Topics: Adenomatous Polyposis Coli Protein; Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; | 2002 |
Incorporation of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) into fur and correlation with intestinal tumourigenesis in Min/+ mice.Pharmacology & toxicology, 2003, Volume: 92, Issue:3
Topics: Animals; Animals, Newborn; Carcinogens; Chromatography, High Pressure Liquid; Dose-Response Relation | 2003 |
Dietary retinoic acid supplementation stimulates intestinal tumour formation and growth in multiple intestinal neoplasia (Min)/+ mice.Carcinogenesis, 2004, Volume: 25, Issue:1
Topics: Animals; beta Catenin; Body Weight; Cyclin D1; Cytoskeletal Proteins; Dietary Supplements; Female; G | 2004 |
Adenomatous polyposis coli truncation mutations in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumours of multiple intestinal neoplasia mice.Mutation research, 2004, Jan-10, Volume: 557, Issue:1
Topics: Animals; Dose-Response Relationship, Drug; Female; Genes, APC; Imidazoles; Intestinal Neoplasms; Los | 2004 |
Lack of large intestinal carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine at low doses in rats initiated with azoxymethane.International journal of cancer, 2005, Jul-20, Volume: 115, Issue:6
Topics: Animals; Azo Compounds; Carcinogens; Dose-Response Relationship, Drug; Imidazoles; Intestinal Neopla | 2005 |
Impact of genetic background on spontaneous or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumorigenesis in Min/+ mice.Cancer letters, 2006, Aug-28, Volume: 240, Issue:2
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Genes, APC; Imidazoles; Intestinal Ne | 2006 |
Role of nucleotide excision repair deficiency in intestinal tumorigenesis in multiple intestinal neoplasia (Min) mice.Mutation research, 2006, Dec-10, Volume: 611, Issue:1-2
Topics: Animals; Body Weight; Colon; DNA Adducts; DNA Repair; Dose-Response Relationship, Drug; Female; Imid | 2006 |
Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay.Carcinogenesis, 1994, Volume: 15, Issue:11
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Butylhydroxybutylnitrosamine; Carcinogens; Diethylnitro | 1994 |
Inhibition of 2-Amino-1-methyl-6-phenylimidazo[4,5]pyridine-induced lymphoma formation by oltipraz.Cancer research, 1996, Aug-01, Volume: 56, Issue:15
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Imidazoles; Intestinal Neoplasms; Lympho | 1996 |
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies.Princess Takamatsu symposia, 1995, Volume: 23Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; Diet; DNA Adducts; Dose- | 1995 |
Short-term carcinogenicity testing of a potent murine intestinal mutagen, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), in Apc1638N transgenic mice.Carcinogenesis, 1997, Volume: 18, Issue:4
Topics: Animals; Body Weight; Carcinogenicity Tests; Female; Frameshift Mutation; Genes, APC; Imidazoles; In | 1997 |
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine increases the numbers of tumors, cystic crypts and aberrant crypt foci in multiple intestinal neoplasia mice.Carcinogenesis, 1997, Volume: 18, Issue:5
Topics: Animals; Female; Genes, APC; Imidazoles; Intestinal Neoplasms; Intestine, Large; Intestine, Small; M | 1997 |
Modification by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) of 3,2'-dimethyl-4-aminobiphenyl (DMAB)-induced rat pancreatic and intestinal tumorigenesis.Cancer letters, 1998, Feb-13, Volume: 124, Issue:1
Topics: Adenocarcinoma; Aminobiphenyl Compounds; Animals; Body Weight; Carcinogens; Drug Synergism; Imidazol | 1998 |
Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice.Carcinogenesis, 1999, Volume: 20, Issue:7
Topics: Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Cell Division; Dose-Response Relation | 1999 |
DNA adduct levels and intestinal lesions in congenic rapid and slow acetylator syrian hamsters admi food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).Pharmacology & toxicology, 2000, Volume: 86, Issue:6
Topics: Acetylation; Adenoma; Animals; Animals, Congenic; Arylamine N-Acetyltransferase; Cricetinae; DNA Add | 2000 |
More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated rats.Japanese journal of cancer research : Gann, 2000, Volume: 91, Issue:8
Topics: Adenocarcinoma; Adenoma; Amino Acid Sequence; Animals; Base Sequence; beta Catenin; Cytoskeletal Pro | 2000 |
Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice.Carcinogenesis, 2001, Volume: 22, Issue:4
Topics: Adenocarcinoma; Adenoma; Animals; Body Weight; Carcinogens; DNA Mutational Analysis; DNA Repair; Dos | 2001 |
Curcumin modifies Apc(min) apoptosis resistance and inhibits 2-amino 1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced tumour formation in Apc(min) mice.Carcinogenesis, 2001, Volume: 22, Issue:5
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Base Sequence; Carcinogens; Curcumin; DNA Primers; Gene | 2001 |
Intestinal tumours induced by the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in multiple intestinal neoplasia mice have truncation mutations as well as loss of the wild-type Apc(+) allele.Mutagenesis, 2001, Volume: 16, Issue:4
Topics: Adenoma; Alleles; Animals; Carcinogens; Female; Genes, APC; Imidazoles; Incidence; Intestinal Neopla | 2001 |
Organ dependent enhancement of rat 3,2'-dimethyl-4-aminobiphenyl (DMAB) carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): positive effects on the intestine but not the prostate.Carcinogenesis, 2001, Volume: 22, Issue:8
Topics: Aminobiphenyl Compounds; Animals; Carcinogens; DNA Adducts; Drug Synergism; Imidazoles; Immunohistoc | 2001 |
Intestinal tumorigenesis in multiple intestinal neoplasia mice induced by the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: perinatal susceptibility, regional variation, and correlation with DNA adducts.Cancer research, 2001, Dec-15, Volume: 61, Issue:24
Topics: Administration, Oral; Age Factors; Animals; Animals, Newborn; Carcinogens; Disease Models, Animal; D | 2001 |
Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet.Carcinogenesis, 2002, Volume: 23, Issue:1
Topics: Adenomatous Polyposis Coli Protein; Animals; beta Catenin; Cytoskeletal Proteins; Dietary Fats; DNA | 2002 |
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats.Carcinogenesis, 2002, Volume: 23, Issue:2
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animal Feed; Animals; Carcinogens; Colonic Neoplasms; DNA Add | 2002 |
Induction of intestinal tumors and lymphomas in C57BL/6N mice by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.Japanese journal of cancer research : Gann, 2002, Volume: 93, Issue:5
Topics: Adenoma; Animals; Carcinogens; Female; Imidazoles; Immunohistochemistry; Intestinal Neoplasms; Lymph | 2002 |
Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats.Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:4
Topics: Adenocarcinoma; Adenoma; Albumins; Animals; Carcinogenicity Tests; Cattle; Cooking; Food Contaminati | 1991 |