2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Cancer of Colon in 84 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response modelling of the data for these three tumour types gives BMDL10 values of 0." | 2.46 | Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine). ( Carthew, P; DiNovi, M; Setzer, RW, 2010) |
| "As for colon cancer models in rodents, Apc-disrupted mice, including ApcMin, have been one of the most widely utilized animal models to dissect the molecular events implicated in the development of intestinal tumors." | 2.43 | Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP. ( Nakagama, H; Nakanishi, M; Ochiai, M, 2005) |
| "The PhIP-induced colon cancer model in rats, thus contributes as a relevant tool to elucidate genetic factors responsible for susceptibility to colon carcinogenesis in human." | 2.41 | A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP. ( Fujiwara, K; Nagao, M; Nakagama, H; Ochiai, M; Sugimura, T; Tajima, R; Ubagai, T, 2002) |
| "PhIP induces colon cancer in male Fischer 344 (F344) rats, and its role in human colon carcinogenesis has been suspected." | 2.40 | Genetic determinant and environmental carcinogens. ( Nagao, M; Nakagama, H; Ochiai, M; Sugimura, T; Ushijima, T; Watanabe, M, 1998) |
| "Chronic colitis was induced by oral administration of dextran sulphate sodium (DSS) to Fischer 344 rats." | 1.43 | Impact of dextran sulphate sodium-induced colitis on the intestinal transport of the colon carcinogen PhIP. ( Breves, G; Giovannini, S; Kershaw, O; Nicken, P; Ostermann, AI; Schebb, NH; Steinberg, P; von Keutz, A; Willenberg, I, 2016) |
| "Obesity is highly associated with colon cancer development." | 1.40 | AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats. ( Fukuda, H; Hippo, Y; Igarashi, M; Nakagama, H; Ochiai, M, 2014) |
| "Lymphocytes from colon cancer patients had greater baseline DNA damage than those from healthy individuals (P<0." | 1.38 | The protective effect of the flavonoids on food-mutagen-induced DNA damage in peripheral blood lymphocytes from colon cancer patients. ( Anderson, D; Baumgartner, A; Kurzawa-Zegota, M; Najafzadeh, M, 2012) |
| "Considering the increased colon cancer risk associated with chronic colitis, we have therefore examined the effects of long-acting hGly(2)GLP-2, as well as of endogenous GLP-2 using the antagonist hGLP-2(3-33) in two novel models of inflammation-associated colon cancer: rats fed the carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet (HFD) for one or three cycles, and mice with chronic dextran sodium-sulfate (DSS)-induced colitis administered AOM." | 1.38 | Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer. ( Brubaker, PL; El-Zimaity, HM; Trivedi, S; Wiber, SC, 2012) |
| "These targets of altered miRNAs in colon cancers have been implicated in tumor recurrence and reduced patient survival, in addition to their role as pluripotency factors." | 1.38 | MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. ( Abdelli, A; Bailey, GS; Dashwood, RH; Dashwood, WM; Ho, E; Parasramka, MA; Wang, R; Williams, DE, 2012) |
| "In HT29 human colon cancer cells, Nox1 knockdown induced G1 cell cycle arrest, whereas in Caco-2 cells there was a strong apoptotic response, with increased levels of cleaved caspase-3, -6, -7 and poly(ADP-ribose)polymerase." | 1.37 | NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). ( Ashktorab, H; Dashwood, RH; Dashwood, WM; Fischer, KA; Löhr, CV; Nakagama, H; Nian, H; Tsuchiya, N; Wang, R, 2011) |
| " To distinguish between blocking and suppressing effects, and thus provide mechanistic insights into prevention during the initiation versus post-initiation phases of carcinogenesis, white tea, and green tea were administered at 2% (w/v) as the sole source of drinking fluid either 2 wk before and 2 wk during PhIP dosing (100 mg/kg, every other day by oral gavage), or starting 1 wk after the carcinogen and continued until the study was terminated at 16 wk." | 1.34 | Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts. ( Bailey, GS; Carter, O; Dashwood, RH; Dashwood, WM; Fischer, KA; Löhr, CV; Orner, GA; Pereira, CB; Wang, R; Williams, DE, 2007) |
| " In the present study, groups of 6-week-old F344 and ACI male rats, the former strain being susceptible to colon carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and the latter being relatively resistant, were subjected to a long-term carcinogenesis experiment using our intermittent feeding protocol of PhIP in combination with a high-fat diet, which serves as a relevant risk factor that promotes the development of colon cancers." | 1.32 | Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat. ( Fujiwara, K; Nagao, M; Nakagama, H; Ochiai, M; Ohki, M; Ohta, T; Sugimura, T; Ubagai, T, 2003) |
| " These featured dietary administration of PhIP at different dose levels and for different durations, and included intragastric dosing for a short period, or continuous dietary administration after initiation with other carcinogen, namely 3,2'-dimethyl-4-aminobiphenyl (DMAB) or 1,2-dimethylhydrazine (DMH)." | 1.31 | Organ differences in the enhancing potential of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on carcinogenicity in the prostate, colon and pancreas. ( Asamoto, M; Futakuchi, M; Imaida, K; Kato, K; Shirai, T; Suzuki, S; Takahashi, S, 2002) |
| " Chronic administration of PhIP or IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of the colon, and short-term treatment leads to the formation of colonic aberrant crypt foci (ACF)." | 1.30 | Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis. ( Dashwood, RH; Xu, M, 1999) |
| " The results indicate that unconjugated N-OH-PhIP is not excreted in the urine after oral dosing with PhIP and that the two isomeric N-glucuronides of N-OH-PhIP, which are formed as major metabolites, are stable under acidic conditions." | 1.29 | Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis. ( Bartsch, H; Butler, MA; Friesen, MD; Ilett, KF; Kaderlik, RK; Kadlubar, F; Lin, D; Minchin, RF; Mulder, GJ; Teitel, CH, 1995) |
| "The carcinogenic potential of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), identified as the most abundant mutagenic heterocyclic amine in cooked meat and fish, was investigated in dose-response studies." | 1.29 | Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies. ( Hasegawa, R; Ito, N; Masui, T; Sano, M; Shirai, T; Tamano, S, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.19) | 18.7374 |
| 1990's | 30 (35.71) | 18.2507 |
| 2000's | 34 (40.48) | 29.6817 |
| 2010's | 18 (21.43) | 24.3611 |
| 2020's | 1 (1.19) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, X | 1 |
| Peng, H | 1 |
| Luo, Z | 1 |
| Luo, A | 1 |
| Cai, M | 1 |
| Xu, L | 1 |
| Wang, H | 4 |
| Ho, V | 1 |
| Brunetti, V | 1 |
| Peacock, S | 1 |
| Massey, TE | 1 |
| Godschalk, RWL | 1 |
| van Schooten, FJ | 1 |
| Ashbury, JE | 1 |
| Vanner, SJ | 1 |
| King, WD | 1 |
| Miller, PE | 1 |
| Lazarus, P | 1 |
| Lesko, SM | 1 |
| Cross, AJ | 1 |
| Sinha, R | 1 |
| Laio, J | 1 |
| Zhu, J | 1 |
| Harper, G | 1 |
| Muscat, JE | 1 |
| Hartman, TJ | 1 |
| Igarashi, M | 1 |
| Hippo, Y | 1 |
| Ochiai, M | 12 |
| Fukuda, H | 2 |
| Nakagama, H | 18 |
| Zhou, H | 1 |
| Liu, A | 3 |
| Guo, X | 1 |
| Yang, CS | 4 |
| Nicken, P | 2 |
| von Keutz, A | 2 |
| Willenberg, I | 1 |
| Ostermann, AI | 1 |
| Schebb, NH | 1 |
| Giovannini, S | 1 |
| Kershaw, O | 1 |
| Breves, G | 2 |
| Steinberg, P | 3 |
| Chen, JX | 2 |
| Lee, MJ | 1 |
| Yu, S | 1 |
| Chi, E | 1 |
| Reuhl, K | 2 |
| Suh, N | 1 |
| Zhang, L | 1 |
| Takamura-Enya, T | 1 |
| Masuda, Y | 1 |
| Nohmi, T | 1 |
| Seki, C | 1 |
| Kamiya, K | 1 |
| Sugimura, T | 22 |
| Masutani, C | 1 |
| Hanaoka, F | 1 |
| Carthew, P | 1 |
| DiNovi, M | 1 |
| Setzer, RW | 1 |
| Wang, R | 4 |
| Dashwood, WM | 5 |
| Nian, H | 1 |
| Löhr, CV | 4 |
| Fischer, KA | 4 |
| Tsuchiya, N | 2 |
| Ashktorab, H | 1 |
| Dashwood, RH | 10 |
| Cheung, C | 1 |
| Loy, S | 1 |
| Li, GX | 1 |
| Liu, AB | 1 |
| Tang, MX | 1 |
| Ogawa, K | 5 |
| Asamoto, M | 6 |
| Chewonarin, T | 2 |
| Suzuki, S | 3 |
| Tanaka, T | 3 |
| Shirai, T | 14 |
| Dietrich, CG | 1 |
| Vehr, AK | 1 |
| Martin, IV | 1 |
| Gassler, N | 1 |
| Rath, T | 1 |
| Roeb, E | 1 |
| Schmitt, J | 1 |
| Trautwein, C | 1 |
| Geier, A | 1 |
| Kurzawa-Zegota, M | 1 |
| Najafzadeh, M | 1 |
| Baumgartner, A | 1 |
| Anderson, D | 1 |
| Trivedi, S | 1 |
| Wiber, SC | 1 |
| El-Zimaity, HM | 1 |
| Brubaker, PL | 1 |
| Parasramka, MA | 1 |
| Abdelli, A | 1 |
| Bailey, GS | 4 |
| Williams, DE | 4 |
| Ho, E | 1 |
| Williamson, R | 1 |
| Schröder, B | 1 |
| Kato, K | 2 |
| Futakuchi, M | 4 |
| Takahashi, S | 5 |
| Imaida, K | 5 |
| Ubagai, T | 3 |
| Tajima, R | 1 |
| Fujiwara, K | 4 |
| Nagao, M | 17 |
| Ferguson, LR | 1 |
| Takeshita, F | 1 |
| Ohki, M | 2 |
| Ohta, T | 2 |
| Ushigome, M | 1 |
| Kawamori, T | 1 |
| Inaguma, S | 1 |
| Ohnishi, H | 1 |
| Cho, YM | 2 |
| Hikosaka, A | 1 |
| Hokaiwado, N | 1 |
| Kuzutani, K | 1 |
| Kohri, K | 1 |
| Fukushima, S | 2 |
| Wanibuchi, H | 2 |
| Morimura, K | 1 |
| Iwai, S | 1 |
| Nakae, D | 1 |
| Kishida, H | 1 |
| Tsuda, H | 2 |
| Uehara, N | 2 |
| Tatematsu, M | 2 |
| Tsukamoto, T | 2 |
| Hirose, M | 7 |
| Furukawa, F | 1 |
| Aburatani, H | 1 |
| Suzuki, R | 1 |
| Kohno, H | 1 |
| Sugie, S | 1 |
| Takahashi, M | 3 |
| Wakabayashi, K | 5 |
| Nishikawa, A | 1 |
| Imazawa, T | 1 |
| Kuroiwa, Y | 1 |
| Kitamura, Y | 1 |
| Kanki, K | 1 |
| Ishii, Y | 1 |
| Umemura, T | 1 |
| Watanabe, M | 6 |
| Nakanishi, M | 3 |
| Taguchi, A | 1 |
| Ikeda, Y | 1 |
| Tang, M | 1 |
| Smith-Roe, SL | 1 |
| Bildfell, RJ | 1 |
| Hegan, DC | 1 |
| Glazer, PM | 1 |
| Buermeyer, AB | 1 |
| Andreassen, A | 1 |
| Vikse, R | 1 |
| Mikalsen, A | 1 |
| Adamovic, T | 1 |
| Steffensen, IL | 1 |
| Hjertholm, H | 1 |
| Levan, G | 1 |
| Alexander, J | 2 |
| Li, Q | 1 |
| Zhong, X | 1 |
| Carter, O | 1 |
| Orner, GA | 2 |
| Pereira, CB | 2 |
| Tazawa, H | 1 |
| Louderback, M | 1 |
| Doi, K | 1 |
| Hagihara, A | 1 |
| Wei, M | 1 |
| Yunoki, T | 1 |
| Kakiuchi, H | 5 |
| Ushijima, T | 7 |
| Toyota, M | 2 |
| Imai, K | 3 |
| Weisburger, JH | 2 |
| Braley, J | 1 |
| Reinhardt, J | 1 |
| Aliaga, C | 1 |
| Rivenson, A | 1 |
| Hard, GC | 1 |
| Zhang, XM | 1 |
| Esumi, H | 2 |
| Canzian, F | 2 |
| Serikawa, T | 1 |
| Makino, H | 2 |
| Onda, M | 1 |
| Ito, N | 7 |
| Hasegawa, R | 4 |
| Sano, M | 3 |
| Tamano, S | 5 |
| Yachi, A | 1 |
| Kushida, H | 1 |
| Guo, D | 1 |
| Schut, HA | 3 |
| Davis, CD | 1 |
| Snyderwine, EG | 1 |
| Kadlubar, F | 1 |
| Kaderlik, RK | 1 |
| Mulder, GJ | 1 |
| Lin, D | 1 |
| Butler, MA | 1 |
| Teitel, CH | 1 |
| Minchin, RF | 1 |
| Ilett, KF | 1 |
| Friesen, MD | 1 |
| Bartsch, H | 1 |
| Masui, T | 1 |
| Inoue, R | 1 |
| Ishiguro, Y | 2 |
| Kristiansen, E | 1 |
| Hagiwara, A | 2 |
| Totsuka, Y | 1 |
| Masuda, M | 1 |
| Fukuda, K | 1 |
| Oguri, A | 1 |
| Yazawa, K | 1 |
| Suzui, M | 1 |
| Shen, CL | 1 |
| Purewal, M | 2 |
| San Francisco, S | 1 |
| Pence, BC | 1 |
| Malfatti, MA | 1 |
| Kulp, KS | 1 |
| Knize, MG | 1 |
| Davis, C | 1 |
| Massengill, JP | 1 |
| Williams, S | 1 |
| Nowell, S | 2 |
| MacLeod, S | 1 |
| Dingley, KH | 2 |
| Turteltaub, KW | 2 |
| Lang, NP | 2 |
| Felton, JS | 2 |
| Boonyaphiphat, P | 1 |
| Tanaka, H | 1 |
| Kawabe, M | 1 |
| Kaneko, H | 1 |
| Matsui, M | 1 |
| Curtis, KD | 1 |
| Kozaki, K | 1 |
| Nishikawa, Y | 1 |
| Yamamoto, M | 1 |
| Fukami, H | 1 |
| Inoue, M | 1 |
| Kinouchi, T | 1 |
| Kataoka, K | 1 |
| Arimochi, H | 1 |
| Kuwahara, T | 1 |
| Vinitketkumnuen, U | 1 |
| Ohnishi, Y | 1 |
| Shibutani, M | 1 |
| Uneyama, C | 1 |
| Toyoda, K | 1 |
| Iwata, H | 1 |
| Xu, M | 3 |
| Sekine, K | 1 |
| Takasuka, N | 1 |
| Moore, MA | 1 |
| Konno, Y | 1 |
| Nakashita, K | 1 |
| Degawa, M | 1 |
| Fretland, AJ | 1 |
| Hein, DW | 1 |
| Wargovich, MJ | 1 |
| Yamaguchi, T | 1 |
| Lin, C | 1 |
| Kimoto, N | 1 |
| Kono, T | 1 |
| Nishibe, S | 1 |
| Glaab, WE | 1 |
| Kort, KL | 1 |
| Skopek, TR | 1 |
| Paulsen, JE | 1 |
| Fulland, RC | 1 |
| Burnouf, D | 1 |
| Miturski, R | 1 |
| Nothisen, M | 1 |
| Wagner, J | 1 |
| Fuchs, RP | 1 |
| Yu, Z | 1 |
| Santana-Rios, G | 2 |
| Shen, R | 1 |
| Izquierdo-Pulido, M | 2 |
| Zhang, S | 1 |
| Lloyd, R | 1 |
| Bowden, G | 1 |
| Glickman, BW | 1 |
| de Boer, JG | 1 |
| Miki, T | 1 |
| Herzog, CR | 1 |
| Takayama, S | 1 |
| Tudek, B | 1 |
| Bird, RP | 1 |
| Bruce, WR | 1 |
| Kühnel, D | 1 |
| Taugner, F | 1 |
| Scholtka, B | 1 |
| Sliva, D | 1 |
| Loganathan, J | 1 |
| Jiang, J | 1 |
| Jedinak, A | 1 |
| Lamb, JG | 1 |
| Terry, C | 1 |
| Baldridge, LA | 1 |
| Adamec, J | 1 |
| Sandusky, GE | 1 |
| Dudhgaonkar, S | 1 |
6 reviews available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cancer of Colon
| Article | Year |
|---|---|
Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine).
Topics: Animals; Breast Neoplasms; Carcinogens; Colonic Neoplasms; Cooking; Data Interpretation, Statistical | 2010 |
A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP.
Topics: Animals; Carcinogens; Chromosomes; Colonic Neoplasms; Disease Models, Animal; Disease Progression; G | 2002 |
Meat consumption, cancer risk and population groups within New Zealand.
Topics: Animals; Carcinogens; Cattle; Chickens; Colonic Neoplasms; Dietary Proteins; Eating; Fishes; Humans; | 2002 |
Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Colonic Neoplasms; Dise | 2005 |
[Risk factors for non-hereditary colonic cancers].
Topics: Alcohol Drinking; Animals; Colonic Neoplasms; Diet; Dietary Fats; Disease Models, Animal; Environmen | 2007 |
Genetic determinant and environmental carcinogens.
Topics: Animals; Carcinogens, Environmental; Colonic Neoplasms; Female; Genotype; Humans; Imidazoles; Male; | 1998 |
78 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Cancer of Colon
| Article | Year |
|---|---|
The dietary carcinogen PhIP activates p53-dependent DNA damage response in the colon of CYP1A-humanized mice.
Topics: Animals; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Carcinogens; Colonic Neoplasms; | 2021 |
Exposure to meat-derived carcinogens and bulky DNA adduct levels in normal-appearing colon mucosa.
Topics: Adult; Aged; Biotransformation; Carcinogens; Colon; Colonic Neoplasms; Colonoscopy; Cross-Sectional | 2017 |
Meat-related compounds and colorectal cancer risk by anatomical subsite.
Topics: Aged; Animals; Benzo(a)pyrene; Case-Control Studies; Colonic Neoplasms; Colorectal Neoplasms; Cookin | 2013 |
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Carcinogenesis; Carcinogens; Cell Line; Colon; Colonic Neop | 2014 |
Genetic analysis of colon tumors induced by a dietary carcinogen PhIP in CYP1A humanized mice: Identification of mutation of β-catenin/Ctnnb1 as the driver gene for the carcinogenesis.
Topics: Animals; beta Catenin; Carcinogenesis; Carcinogens; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Diet | 2015 |
Impact of dextran sulphate sodium-induced colitis on the intestinal transport of the colon carcinogen PhIP.
Topics: Animals; Carcinogens; Chromatography, Liquid; Chronic Disease; Colitis; Colonic Neoplasms; Dextran S | 2016 |
δ- and γ-tocopherols inhibit phIP/DSS-induced colon carcinogenesis by protection against early cellular and DNA damages.
Topics: Animals; Anticarcinogenic Agents; Carcinogenesis; Colon; Colonic Neoplasms; Cytochrome P-450 CYP1A1; | 2017 |
From the Cover: PhIP/DSS-Induced Colon Carcinogenesis in CYP1A-Humanized Mice and the Possible Role of Lgr5+ Stem Cells.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Dextran Sulfate; Female; Humans; Imidazoles; Mice; Mic | 2017 |
Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro: REV1 inserts dC opposite the lesion, and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dC terminus.
Topics: Animals; Cell-Free System; Colonic Neoplasms; DNA Adducts; DNA-Directed DNA Polymerase; DNA, Neoplas | 2009 |
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Topics: Aged; Aged, 80 and over; Animals; Apoptosis; Blotting, Western; Carcinogens; Case-Control Studies; C | 2011 |
Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate.
Topics: Animals; beta Catenin; Biotransformation; Carcinogens; Colonic Neoplasms; Cytochrome P-450 CYP1A1; C | 2011 |
Effects of nobiletin on PhIP-induced prostate and colon carcinogenesis in F344 rats.
Topics: Aberrant Crypt Foci; Adenocarcinoma; Animals; Carcinogens; Chemoprevention; Colonic Neoplasms; Flavo | 2011 |
Downregulation of breast cancer resistance protein in colon adenomas reduces cellular xenobiotic resistance and leads to accumulation of a food-derived carcinogen.
Topics: Adenoma; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Tran | 2011 |
The protective effect of the flavonoids on food-mutagen-induced DNA damage in peripheral blood lymphocytes from colon cancer patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cells, Cultured; Colonic Neoplasms; DNA Damage; Dose-Res | 2012 |
Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer.
Topics: Animals; Azoxymethane; beta Catenin; Blotting, Western; Carcinogens; Colitis; Colonic Neoplasms; Dex | 2012 |
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.
Topics: Animals; Carcinogens; Colonic Neoplasms; Computer Simulation; Gene Expression Regulation, Neoplastic | 2012 |
Scientists complete miRNA profiling of carcinogen-induced and spinach-fed colon tumors.
Topics: Animals; Carcinogens; Colonic Neoplasms; Gene Expression Profiling; Humans; Imidazoles; MicroRNAs; N | 2012 |
The colon carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is actively secreted in the distal colon of the rat: an integrated view on the role of PhIP transport and metabolism in PhIP-induced colon carcinogenesis.
Topics: Adenocarcinoma; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Casset | 2013 |
Organ differences in the enhancing potential of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on carcinogenicity in the prostate, colon and pancreas.
Topics: 1,2-Dimethylhydrazine; Aminobiphenyl Compounds; Animals; Carcinogens; Colon; Colonic Neoplasms; DNA | 2002 |
Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Animals; Antimetabolites, Antineoplastic; Blotting, Western; Body Weight; Breast; Bromodeoxyuridine; | 2003 |
Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat.
Topics: Animals; Base Sequence; Carcinogens; Chromosome Mapping; Colonic Neoplasms; Dietary Fats; DNA Primer | 2003 |
Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Adenocarcinoma; Adenoma; Animals; beta Catenin; Carcinogens; Cell Division; Colon; Colonic Neoplasms | 2003 |
High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) prostate carcinogenesis.
Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Disease Progression; Disease S | 2003 |
Inhibitory effects of soy isoflavones on rat prostate carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Topics: Animals; Antineoplastic Agents; Body Weight; Carcinogens; Colonic Neoplasms; Imidazoles; Isoflavones | 2004 |
Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Colon; Colonic Neoplasms; Deoxyguanosine; DNA Add | 2004 |
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Alcian Blue; Animals; Carcinogens; Cell Differentiation; Cell Line, Tumor; Colonic Neoplasms; Cyclin | 2004 |
Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cycloox
Topics: Adenocarcinoma; Animals; Anticoagulants; Base Sequence; beta Catenin; Carcinogens; Colonic Neoplasms | 2005 |
Induction of colon tumors in C57BL/6J mice fed MeIQx, IQ, or PhIP followed by dextran sulfate sodium treatment.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dextran Sul | 2005 |
Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Imidazoles; Male; Methylene Blue; Pr | 2005 |
Equivocal impact of transplacental and lactational exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, on prostate and colon lesion development in F344 rats.
Topics: Animals; Carcinogens; Colonic Diseases; Colonic Neoplasms; Female; Imidazoles; Immunohistochemistry; | 2005 |
Induction of aberrant crypt foci in DNA mismatch repair-deficient mice by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP).
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinogens; Carrier Proteins; Colon; Colonic Neoplas | 2006 |
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induces genetic changes in murine intestinal tumours and cells with ApcMin mutation.
Topics: Allelic Imbalance; Animals; Cell Line, Tumor; Colonic Neoplasms; Genes, APC; Imidazoles; Mice; Mice, | 2006 |
Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1.
Topics: Animals; bcl-2-Associated X Protein; beta Catenin; Carcinogens; Cell Line; Cloning, Molecular; Colon | 2007 |
Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts.
Topics: Animals; Anticarcinogenic Agents; Caffeine; Carcinogens; Catechin; Cell Division; Colon; Colonic Neo | 2007 |
Mouse strain differences in inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to PhIP-induced large bowel carcinogenesis.
Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Colitis; Colon; Colon | 2007 |
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.
Topics: Animals; Anticarcinogenic Agents; beta Catenin; Caffeine; Carcinogens; Catechin; Colonic Neoplasms; | 2008 |
Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine initiation-promotion model.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dose-Response Relationship, D | 2007 |
Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Animals; Base Sequence; Carcinogens; Cloning, Molecular; Colonic Neoplasms; DNA Mutational Analysis; | 1995 |
The role of fat and calcium in the production of foci of aberrant crypts in the colon of rats fed 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine.
Topics: Animals; Calcium, Dietary; Carcinogens; Colonic Neoplasms; Diet; Dietary Fats; Evaluation Studies as | 1994 |
Instability of microsatellites in rat colon tumors induced by heterocyclic amines.
Topics: Animals; Colonic Neoplasms; DNA, Neoplasm; DNA, Satellite; Imidazoles; Male; Mutation; Quinolines; R | 1994 |
Absence of p53 mutations in rat colon tumors induced by 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole, 2-amino-3-methylimidazo[4,5-f]quinoline, or 2-amino-1-methyl-6-phenylimidazo]4,5-b]pyridine.
Topics: Adenocarcinoma; Adenoma; Animals; Base Sequence; Carcinogens; Colonic Neoplasms; Genes, ras; Imidazo | 1994 |
Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats.
Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dose-Response Relati | 1993 |
Rare frequency of activation of the Ki-ras gene in rat colon tumors induced by heterocyclic amines: possible alternative mechanisms of human colon carcinogenesis.
Topics: Adenocarcinoma; Amines; Animals; Base Sequence; Carcinogens; Codon; Colonic Neoplasms; Exons; Gene E | 1993 |
DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis.
Topics: Animals; Carcinogens; Cell Division; Colonic Neoplasms; DNA Adducts; Female; Imidazoles; Male; Mutag | 1996 |
Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Chlorophyllides; Colon; Colonic Neoplasms; DNA; DNA A | 1995 |
Genetic alterations in rat colon tumors induced by heterocyclic amines.
Topics: Animals; Base Sequence; Carcinogens; Colonic Neoplasms; DNA Fingerprinting; DNA, Neoplasm; DNA, Sate | 1996 |
Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis.
Topics: Animals; Arylamine N-Acetyltransferase; Biotransformation; Carcinogens; Colonic Neoplasms; Cytochrom | 1995 |
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; Diet; DNA Adducts; Dose- | 1995 |
Genetic alterations in HCA-induced tumors.
Topics: Animals; Carcinogens; Colonic Neoplasms; Diet; Female; Food; Genes, p53; Genes, ras; Humans; Imidazo | 1995 |
Efficient method for rapid induction of aberrant crypt foci in rats with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Animals; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Dietary Fats; Imidazoles; Male; Precanc | 1996 |
The role of aberrant crypt foci induced by the two heterocyclic amines 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) in the development of colon cancer in mice.
Topics: Animals; Carcinogens; Colon; Colonic Neoplasms; Female; Imidazoles; Mice; Mice, Inbred C57BL; Neopla | 1996 |
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.
Topics: Adenocarcinoma; Animals; Carcinogens; Chlorophyllides; Colonic Neoplasms; Dose-Response Relationship | 1997 |
Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA).
Topics: Animals; Carcinogens; Colon; Colonic Neoplasms; DNA Adducts; Docosahexaenoic Acids; Imidazoles; Male | 1997 |
High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.
Topics: Animals; beta Catenin; Colonic Neoplasms; Cytoskeletal Proteins; DNA, Neoplasm; Imidazoles; Mammary | 1998 |
Absence of PhIP adducts, p53 and Apc mutations, in rats fed a cooked beef diet containing a high level of heterocyclic amines.
Topics: Animals; Base Sequence; Carcinogens; Cattle; Colonic Neoplasms; Cooking; DNA Primers; Genes, APC; Ge | 1998 |
The identification of [2-(14)C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans.
Topics: Administration, Oral; Aged; Aged, 80 and over; Animals; Biotransformation; Carcinogens; Chromatograp | 1999 |
Strain differences of rats in the susceptibility to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine: no implication of Apc and Pla2g2a genetic polymorphisms in differential susceptibility.
Topics: Animals; Base Sequence; Carcinogens; Colon; Colonic Neoplasms; DNA Adducts; DNA Primers; Genes, APC; | 1999 |
Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants alpha-tocopherol and n-tritriacontane-16,18-dione, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary and colonic carcinogenesis in female F344
Topics: Adenocarcinoma; Adenoma; Animals; Antioxidants; Caffeine; Carcinogens; Chemoprevention; Colonic Neop | 1999 |
DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Adult; Aged; Aged, 80 and over; Biological Availability; Carcinogens; Colonic Neoplasms; Cooking; Di | 1999 |
Development and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat large intestine.
Topics: Animals; Colonic Neoplasms; Imidazoles; Intestine, Large; Male; Mutagenicity Tests; Mutagens; Precan | 1999 |
Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-ph
Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Azoxymethane; Chemoprevention; Colonic Neopl | 1999 |
Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats.
Topics: Animals; Antioxidants; Carcinogens; Catechin; Colonic Neoplasms; Drug Antagonism; Imidazoles; Liver | 1999 |
Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Chlorophyllides; Colon; Colonic Neoplasms; | 1999 |
Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats.
Topics: Animals; Caffeine; Carcinogens; Colonic Neoplasms; Drug Synergism; Imidazoles; Liver Neoplasms, Expe | 1999 |
Association between acetylator genotype and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) DNA adduct formation in colon and prostate of inbred Fischer 344 and Wistar Kyoto rats.
Topics: Animals; Carcinogens; Colon; Colonic Neoplasms; DNA Adducts; Genetic Predisposition to Disease; Imid | 2000 |
Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats.
Topics: Animals; Biological Assay; Body Weight; Carcinogens; Carcinoma; Colonic Neoplasms; Diet; Drugs, Chin | 2000 |
Specificity of mutations induced by the food-associated heterocyclic amine 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine in colon cancer cell lines defective in mismatch repair.
Topics: Base Pair Mismatch; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; DNA Mutational Analysis; DNA R | 2000 |
Age-dependent induction of aberrant crypt foci in rat colon by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and azoxymethane.
Topics: Aging; Animals; Azoxymethane; Body Weight; Carcinogens; Choristoma; Colonic Neoplasms; Female; Imida | 2000 |
Early detection of 2-amino-1-methyl-6-phenylimidazo (4,5-b)pyridine(PhIP)-induced mutations within the Apc gene of rat colon.
Topics: Animals; Base Pair Mismatch; Carcinogens; Colonic Neoplasms; DNA Primers; DNA, Neoplasm; Electrophor | 2001 |
A comparison of whole wheat, refined wheat and wheat bran as inhibitors of heterocyclic amines in the Salmonella mutagenicity assay and in the rat colonic aberrant crypt focus assay.
Topics: Amines; Animals; Antimutagenic Agents; Carcinogens; Colon; Colonic Neoplasms; Dietary Fiber; Hydroge | 2001 |
Msh2 DNA mismatch repair gene deficiency and the food-borne mutagen 2-amino-1-methy1-6-phenolimidazo [4,5-b] pyridine (PhIP) synergistically affect mutagenesis in mouse colon.
Topics: Animals; Bacterial Proteins; Base Pair Mismatch; Cocarcinogenesis; Colonic Neoplasms; Diet; DNA Muta | 2001 |
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animal Feed; Animals; Carcinogens; Colonic Neoplasms; DNA Add | 2002 |
Inhibition by white tea of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced colonic aberrant crypts in the F344 rat.
Topics: Animals; Anticarcinogenic Agents; Colon; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-45 | 2001 |
Formation of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in male Fischer-344 rats.
Topics: Animals; Colonic Neoplasms; DNA; Imidazoles; Male; Mutagens; Phosphorus Radioisotopes; Rats; Rats, I | 1992 |
A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Topics: Animals; Colonic Neoplasms; Female; Hot Temperature; Imidazoles; Male; Mammary Neoplasms, Experiment | 1991 |
Foci of aberrant crypts in the colons of mice and rats exposed to carcinogens associated with foods.
Topics: Animals; Carcinogens, Environmental; Colon; Colonic Neoplasms; Diet; Dose-Response Relationship, Dru | 1989 |
Inflammation does not precede or accompany the induction of preneoplastic lesions in the colon of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-fed rats.
Topics: Aminopyridines; Animals; Carcinogens; Colitis; Colon; Colonic Neoplasms; Hyperplasia; Imidazoles; Ma | 2009 |
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Apoptosis; Carcinogens; Cell Proliferation; Cell | 2012 |